1.
Org Lett
; 25(17): 3013-3017, 2023 May 05.
Article
in English
| MEDLINE
| ID: mdl-37083303
ABSTRACT
A method for the regioselective functionalization of haloarenes through deprotonative lithiation is disclosed. The generated haloaryllithiums were trapped in a batch reactor with a zinc chloride diamine complex to provide organozinc species without aryne formation, which reacted with electrophiles to afford the corresponding products in 38-98% yields. This method was applied to the five-step total synthesis of carbazomycin A on a gram scale in 33% overall yield.