ABSTRACT
<p><b>BACKGROUND</b>To investigate the immunohistochemical detected method and the clinical incidence of the bone marrow micrometastases (BMM) in patients with non-small cell lung cancer (NSCLC) and to analyze the sensitivity and specificity and clinical application value.</p><p><b>METHODS</b>Bone marrow samples were collected from the anterior superior iliac spines or posterior superior iliac spines of 53 patients with NSCLC in clinical stage I to III and 15 patients in stage IV, and the BMM was detected by immunohistochemical techniques (IHC) using monoclonal antibodies AE1/AE3 against cytokeratin. Chi-square test was used statistically.</p><p><b>RESULTS</b>The IHC sensitivity could be 10⁻⁵. The BMM positive rate was 22.6% (12/53) in stage I to III and 53.3% (8/15) in stage IV, and there was a significant difference in the BMM positive rate between stage I to III and stage IV (P < 0.05). No correlation was observed between BMM and sex, age, KPS, pathology classification and cancer cell differentiation.</p><p><b>CONCLUSIONS</b>The detection of BMM by IHC is convenient, sensitive, and specific. It might be helpful to diagnose bone marrow micrometastasis in patients with NSCLC.</p>
ABSTRACT
<p><b>BACKGROUND</b>To study the results of combination therapy for adrenal metastasis from lung cancer.</p><p><b>METHODS</b>Thirty patients with adrenal metastasis were treated in our hospital from Feb. 1995 to Apr. 2001. Forteen patients were small cell lung cancer (SCLC) and 16 patients were non-small cell lung cancer (NSCLC). All patients were treated with chemotherapy and/or radiotherapy. Eighteen patients were treated with combination therapy of chemotherapy and radiotherapy, while twelve patients with chemotherapy alone.</p><p><b>RESULTS</b>The median survival time was 8 months. The response rate of chemotherapy alone was 25.0% (partial relief 3 cases), while the response rate of combination therapy was 44.4% (complete relief 1 case and partial relief 7 cases). Pain was relieved quickly after radiotherapy for the patients with pain symptom.</p><p><b>CONCLUSIONS</b>Combination of radiotherapy and chemotherapy is better than chemotherapy alone for the treatment of adrenal metastasis from lung cancer.</p>
ABSTRACT
The value of prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC) remains controversial. From Nov.1987 to Jan. 1993, thirty-one patients with small cell lung cancer received PCI. PCI was given for complete remission SCLC patients after chemotherapy and chest radiotherapy. The total dose of PCI was 40Gy in 26 cases, 30～