ABSTRACT
OBJECTIVES: To assess the effect of beta-blocker treatment on left ventricular global longitudinal strain (LV Gls) as measured by echocardiography in patients with MB (Myocardial Bridge). PATIENTS AND METHODS: Between January 2019 and February 2022, a prospective, single-center study was undertaken in which myocardial bridging was identified in individuals who had coronary angiography. One hundred patients with myocardial bridging were systematically recruited and strain echocardiography was performed. Patient data were analysed in two groups - those who weren't using beta-blockers in the last six months (Group I: n = 50) vs. those who were (Group II: n = 50). RESULTS: One hundred patients participated in the study (38 females, 62 males; average age: 57.4 years). There was a statistically significant difference in the mean heart rate between groups I and II (p < 0.001). LV Gls was found to be statistically significantly improved in favour of group II when compared to group I [Group I: (-12.57)±3 vs. Group II: (-15.92)±2.9, p < 0.001]. CONCLUSION: The negative chronotropic effect of beta-blocker medication in individuals with MB identified by coronary angiography has a beneficial effect on LV Gls as measured by echocardiography.
Subject(s)
Myocardial Bridging , Ventricular Dysfunction, Left , Male , Female , Humans , Middle Aged , Prospective Studies , Myocardial Bridging/diagnostic imaging , Myocardial Bridging/drug therapy , Echocardiography , Heart Ventricles/diagnostic imaging , Myocardium , Adrenergic beta-Antagonists/pharmacology , Adrenergic beta-Antagonists/therapeutic use , Ventricular Function, Left/physiology , Ventricular Dysfunction, Left/diagnostic imaging , Ventricular Dysfunction, Left/drug therapyABSTRACT
Background The prognostic nutritional index (PNI), consisting of albumin and lymphocyte counts, has been associated with satisfactory predictive values ââfor in-hospital mortality or clinical follow-up outcomes in acute situations. In this study, we aimed to evaluate the use of PNI for the prediction of hospital admission in individuals with mildly reduced ejection fraction heart failure (HFmrEF). Methodology This retrospective study was conducted between January 2019 and May 2022 and included 200 patients with HFmrEF detected by transthoracic echocardiography. Data from hospitalized patients (group 1) and outpatients (group 2) were compared. Results In the multivariable regression analysis, brain natriuretic peptide (odds ratio (OR) = 1.001; 95% confidence interval (CI) = 1.000-1.001, p = 0.001) and PNI (OR = 0.783; 95% CI = 0.720-0.853; p < 0.001) were independent predictors of hospital admission in patients with HFmrEF. The PNI value was statistically significantly higher in group 2 (52.36 ± 5.36) than in group 1 (38.3 ± 8.63, p < 0.001). The PNI value <46.75 is a predictor of hospitalization in patients with HFmrEF, with 86% sensitivity and 88% specificity. Conclusions Lower PNI levels predict hospital admission in HFmrEF patients. This measure, which can be easily evaluated in daily cardiological practice, allows for quick and precise decisions for hospitalization.
