ABSTRACT
The lipopolysaccharide (LPS)-induced release of cytokines from human monocytes can be prevented by previous interaction of serum with LPS. This inactivation is a function of lipoproteins. Here we show that LPS can be inactivated by low-density lipoproteins (LDL) as well as by high-density lipoproteins (HDL). The effects of heparin and EDTA on LPS inactivation by serum are also described.
Subject(s)
Bacterial Toxins/immunology , Edetic Acid/pharmacology , Endotoxins , Enterotoxins/immunology , Heparin/pharmacology , Lipopolysaccharides/immunology , Lipoproteins/pharmacology , Monocytes/drug effects , Monokines/physiology , Dose-Response Relationship, Drug , Humans , Lipoproteins, HDL/pharmacology , Lipoproteins, LDL/pharmacology , Lipoproteins, VLDL/pharmacology , Monocytes/immunologyABSTRACT
Lipopolysaccharide (LPS)-induced release of cytokines from human monocytes can be prevented by previous interference of serum with LPS. This inactivation is a function of lipoproteins. Here we show that low-density lipoproteins as well as high-density lipoproteins can inactivate LPS. The effects of heparin and EDTA on LPS inactivation by serum are also described.
