ABSTRACT
OBJECTIVE: To observe nurse administration of carbapenem antibiotics, in the context of medication safety measures, in intensive care units. RESEARCH METHODOLOGY/DESIGN: A quantitative study was conducted using observation principles. SETTING: Three adult private and public Intensive Care Units in the health district of a capital city in KwaZulu-Natal, South Africa. MAIN OUTCOME MEASURES: Nurse practices were observed for double-checking of the medication order, medication vial, and method of preparation and administration. Infusion bags were inspected for nurse labelling of medication and patient details. Patient medication treatment charts were inspected for nurse signature. RESULTS: Carbapenem infusion administrations (n = 223) to twenty patients were observed. Adherence to the scheduled time occurred in 34.9% administrations, 5.4% doses were not given, and an incorrect dose given on 1.4% administrations. One hundred and forty-four (64.6%) infusion bags were inspected during the administrations: there was no medication label affixed to 21.5% bags, and only 8.3% of bags were labelled with essential details; the patient's name, drug, dose, date, time, signature of the nurse mixing and administering the dose, and signature of the secondary nurse. CONCLUSION: There was a lack of compliance with accepted medication risk mitigation measures. Sub-optimal double-checking resulted in the incorrect dose given, missed dose, and non-adherence to scheduled administration time. This has implications for the optimal administration of antimicrobial medications, raising concerns about the efficacy of treatment for critically ill patients. IMPLICATIONS FOR CLINICAL PRACTICE: Parenteral administration errors pose a challenge in acute care areas. Risk mitigation measures include double-checking of medications. If antimicrobial treatment is not administered at the prescribed dosing intervals, this may have implications for the efficacy of time-dependent broad-spectrum antibiotics such as carbapenems. Medication administration errors involving antimicrobial medications should therefore be considered as high-risk errors, with the potential to contribute towards antimicrobial resistance.
Subject(s)
Anti-Infective Agents , Adult , Humans , Cross-Sectional Studies , South Africa , Intensive Care Units , Carbapenems , DocumentationABSTRACT
Extended-spectrum beta-lactamases (ESBLs) were characterized in 41 Salmonella spp. isolates from patients admitted to a pediatric ward of a tertiary hospital in Durban, South Africa. The most common (17/ 41) serotype was Salmonella enterica serotype Typhimurium, followed by S. enterica serotype Isangi (16/41), S. enterica serotype Saint-paul (2/41), S. enterica serotype Kissi (2/41), S. enterica serotype Kivu (2/41), and S. enterica serotype Reading (1/41). All isolates were resistant to ampicillin, amoxicillin-clavulanate, piperacillin, ceftazidime, and aztreonam but susceptible to meropenem. SHV-12 found in 39% of the isolates was the most common ESBL. TEM-63 was produced in 29% and TEM-116 in 10% of the isolates, and TEM-131 was found in 1 isolate. Other ESBLs that were identified included SHV-2 (n = 2), CTX-M-3 (n = 1), CTX-M-15 (n = 2), and CTX-M-37 (n = 5). In addition, CMY-2 (n = 3) and the OXA-1(n = 1) beta-lactamase were also detected. The diversity of ESBLs suggests that its incidence in Salmonellae needs to be monitored.
