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1.
Chinese Medical Journal ; (24): 2066-2076, 2023.
Article in English | WPRIM (Western Pacific) | ID: wpr-1007579

ABSTRACT

BACKGROUND@#Glutamine synthetase (GS) and arginase 1 (Arg1) are widely used pathological markers that discriminate hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma; however, their clinical significance in HCC remains unclear.@*METHODS@#We retrospectively analyzed 431 HCC patients: 251 received hepatectomy alone, and the other 180 received sorafenib as adjuvant treatment after hepatectomy. Expression of GS and Arg1 in tumor specimens was evaluated using immunostaining. mRNA sequencing and immunostaining to detect progenitor markers (cytokeratin 19 [CK19] and epithelial cell adhesion molecule [EpCAM]) and mutant TP53 were also conducted.@*RESULTS@#Up to 72.4% (312/431) of HCC tumors were GS positive (GS+). Of the patients receiving hepatectomy alone, GS negative (GS-) patients had significantly better overall survival (OS) and recurrence-free survival (RFS) than GS+ patients; negative expression of Arg1, which is exclusively expressed in GS- hepatocytes in the healthy liver, had a negative effect on prognosis. Of the patients with a high risk of recurrence who received additional sorafenib treatment, GS- patients tended to have better RFS than GS+ patients, regardless of the expression status of Arg1. GS+ HCC tumors exhibit many features of the established proliferation molecular stratification subtype, including poor differentiation, high alpha-fetoprotein levels, increased progenitor tumor cells, TP53 mutation, and upregulation of multiple tumor-related signaling pathways.@*CONCLUSIONS@#GS- HCC patients have a better prognosis and are more likely to benefit from sorafenib treatment after hepatectomy. Immunostaining of GS may provide a simple and applicable approach for HCC molecular stratification to predict prognosis and guide targeted therapy.


Subject(s)
Humans , Carcinoma, Hepatocellular/metabolism , Sorafenib/therapeutic use , Liver Neoplasms/metabolism , Glutamate-Ammonia Ligase/metabolism , Hepatectomy , Retrospective Studies , Prognosis , Neoplasm Recurrence, Local/surgery
2.
Chinese Critical Care Medicine ; (12): 198-201, 2022.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-931850

ABSTRACT

Sepsis is defined as a life-threatening organ dysfunction caused by the dysregulated host response to infection, and is one of the main causes of death in intensive care unit (ICU) patients. Coagulation dysfunction runs through the pathophysiological progress of sepsis whose severity should be closely related to the prognosis of sepsis. Neutrophil extracellular traps (NETs) is a three-dimensional network structure with DNA as the skeleton and inlaid with various protein components. The excessive production of NETs can lead to sepsis-induced coagulopathy (SIC) by activating the coagulation system, inhibiting the anticoagulation system, resisting fibrinolysis, damaging vascular endothelial cells and the interaction of platelets. At present, the treatment of SIC is mainly symptomatic treatment, and there is no recognized effective anticoagulation strategy. Interventions for NETs and their components, and drugs for antiplatelets are expected to become new directions for disease treatment.

3.
Chinese Critical Care Medicine ; (12): 1222-1226, 2022.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-991946

ABSTRACT

Sepsis associated-acute kidney injury (SA-AKI) is a common complication of sepsis, which has a high incidence and is closely related to a poor prognosis. However, delayed diagnosis and non-specific treatments make it difficult to systematically manage SA-AKI. Based on massive clinical data, machine learning could build prediction models, which provide alarms and suggestions for the clinical decision support system. Although there are still many challenges such as poor interpretability, it has shown clinical application value in SA-SKI risk prediction, imaging diagnosis, subtype identification, prognosis assessment, and so on. Based on a brief introduction of machine learning, this article reviews the application, limitations, and future directions of machine learning in the diagnosis and treatment of SA-AKI, and explores the possibility of machine learning in the medical field, in order to promote the development of precision medicine and intelligent medicine.

4.
Appl Opt ; 59(8): 2621-2631, 2020 Mar 10.
Article in English | MEDLINE | ID: mdl-32225807

ABSTRACT

The far-field diffraction pattern (FFDP) of a corner cube retroreflector (CCR) determines the energy of a retroreflecting beam in some applications including laser ranging, optical communication, and satellite orbit calibration. The FFDP of an imperfect CCR is investigated analytically for the non-normal incidence of a polarized light beam. We first derive a complex amplitude of a retroreflecting beam in relation with multiple parameters including the errors of dihedral angle, flatness in a CCR, and polarization property of the CCR. Then a theoretical expression of the FFDP for a nonideal CCR is deduced as a function of multiple parameters by introducing the complex amplitude into a simplified Kirchhoff's diffraction equation. Some numerically simulated results of the FFDP are presented to give a visual illustration of the relationship between the FFDP and these parameters. Our findings suggest that a strong correlation between the FFDPs and multiple factors comprising the manufacturing errors, the polarization states, and the incident angles of the input beam as well as whether the reflecting faces of the CCR are coated or not. The FFDPs can be efficiently controlled by allocating the magnitudes of these factors. Moreover, experimental verification of the FFDP is also developed for a nonideal CCR coated with silver film on the reflecting faces at a non-normal incidence. The proposed mathematical model potentially offers beneficial ingredients towards optimizing design of a CCR by considering both the manufacturing errors and incident conditions of the input beam.

5.
J Hazard Mater ; 389: 121914, 2020 05 05.
Article in English | MEDLINE | ID: mdl-31879114

ABSTRACT

Dry flue gas desulfurization is an increasingly attractive technique in SO2 emission control. However, the low efficiency in dry desulphurization is the bottleneck of this technology. To find a high-performance desulfurizer is an urgent task. This research utilized a steam jet mill digestion to prepare a desulfurizer at steam temperature of 220 ℃ and pressure of 0.45 MPa, and compared this product with the conventional digestion desulfurizer. Our results show that the digestion in steam jet mill can transform all the calcium oxide into calcium hydroxide. The calcium hydroxide had good fluidity and with honeycomb morphological characteristics. The experiments of dry flue gas desulfurization demonstrated that under the relative humidity of 15, 30 and 45%, the total dead times were 340, 640 and 720 min, the working time for keeping a 100% desulfurization efficiency were 120, 420 and 580 min, and the total sulfur fixation were 124.05, 274.58 and 332.09 mg. Compared with the desulfurizer by conventional dry digestion, the desulfurizer prepared in this research had a significantly superior performance. This experiment provides a new method for high-performance desulfurizer via quicklime digestion, which is an important step in pushing forward the application of dry flue gas desulfurization.

6.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-611125

ABSTRACT

Objective To explore the effects of integrated treatment model (psychosocial interventions combined with drug therapy) in schizophrenia and analyze the influence of medication attitude on treatment compliance and psychiatric symptoms in different intervention models.Methods A total of 170 patients with schizophrenia were enrolled from 2012 to 2015.Patients were randomly divided into two groups:the integrated treatment group (86 patients) with drug therapy and psychosocial intervention,and the conventional drug treatment group (84 patients) with only drug intervention.Dug attitude inventory (DAI),self-awareness inventor (SAI),positive and negative symptoms scale (PANSS) were used to assess medication attitude,treatment compliance and clinical psychotic symptoms for all patients in the following 3 months,6 months and 12 months.Results Compared with medication-alone group,the integrated treatment group achieved significant improvement in psychiatric symptoms,including positive symptom and general psychopathology as well as significant reduction in scores in DAI and SAI (P<0.05).In the conventional drug treatment group,the PANSS score was positively correlated with the increased score of DAI (β=0.31,P=0.02),which was mediated by the improvement in treatment adherence (β=0.18,P=0.18).There was no significant correlation between PANSS score and the increase score of DAI in the integrated treatment group(P=0.62).However,the increased score of SAI was positively correlated with the positive symptom of PANSS scale (r=0.31,P=0.01) and with the general psychiatric symptom scale (r=0.36,P<0.01).Conclusion This study demonstrates that medication attitude can improve the treatment of mental symptoms by increasing compliance in the medication-only group.Symptom improvement is associated with improved compliance but not with medication attitudes in the integrated treatment model.

7.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-426932

ABSTRACT

ObjectiveTo explore the hemodynamic characteristics of parotid glands before and after acid stimulation test in patients with Sjogren syndrome.MethodsTwenty female patients with Sjogren syndrome were enrolled as case group,and 20 healthy women were selected in the same period as control group.The blood flow spectrums of bilateral superficial temporal artery and intra-parotid small artery before and after acid stimulation were detected by color Doppler ultrasonography.Peak systolic velocity (PSV),end-diastolic minimum velocity(EDV) and resistance index( RI ) were obtained and analyzed.ResultsPSV and EDV of intra-parotid small artery in case group were significantly higher than those in control group before acid stimulation test,and RI was obviously lower than that in control group [ ( 16.01 ± 6.18 ) cm/s vs.( 14.00 ± 5.23 ) cm/s,( 5.96 ± 3.00 ) cm/s vs.( 3.54 ± 2.03 ) cm/s,0.64 ± 0.07 vs.0.76 ± 0.06 ] ( P < 0.05 ).In control group,PSV and EDV of superficial temporal artery and intra-parotid small artery increased and RI reduced after acid stimulation test,which had significant differences before and after acid stimulation test (P < 0.05).There was no statistical significance in the hemodynamic indexes of case group before and after acid stimulation test(P> 0.05 ).Conclusions The reactivity of parotid artery to acid stimulation test in patients with Sjogren syndrome reduce,especially the intra-parotid small artery.Color Doppler ultrasonography can contribute to show the hemodynamic changes of the parotid lesions efficiently.

8.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-539246

ABSTRACT

ObjectiveTo discuss the epidemiological characteristic s of road traffic injuries in the Qinghai-Tibet Plateau and explore effective pre ventive measures against traffic accidents in the plateau as well as correspondi ng emergency treatment methods.MethodsA retrospective statis tical analysis was carried out in 1 894 cases of traffic injuries with detailed data admitted in our hospital from January 1980 to December 2000. Resu ltsMost of the traffic accidents occurred on the Qinghai-Tibet road, accounting for 68.0% (1 288/1 894). Of the patients with serious traffic inju ries, 54.0% (1 022/1 894) were in need of hospitalization. The patients who first entered into the plateau accounted for 61.1% (1 158/ 1 894). Death occurre d in 108 cases accounting for 5.7%. The duration from injury to treatment was ve ry long, average over six hours. Furthermore, the patients received no any manag ement before treatment in the hospital. ConclusionsHypoxia i n the plateau, unclear road sign and fatigue driving are the main factors leadin g to traffic accidents. Lack of health care units, serious hypoxia, long deliver y time and carriers' deficiency in medical knowledge are the main causes for gr eat amount of casualties.

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