ABSTRACT
Pre-surgical mapping of sensorimotor and language functions is crucial to reduce neurological deficits in epilepsy and tumor resection surgery. As non-invasive mapping, both resting-state and task-evoked functional MRI has been explored in pre-surgical mapping. In lack of standardized test paradigm, the reliability of fMRI mapping is still a concern for clinical use. In this study, to improve the reliability of fMRI based mapping, task fMRI data from all available task paradigms (motor movement, word repeating and picture naming) were low-pass filtered in the band of resting-state fMRI (0.01-0.08Hz) and concatenated to get more time points. With K-means clustering, it was shown that the sensorimotor network could be reliably parcellated into hand and tongue sub-regions. The resulted parcellations were further verified with invasive ECoG and ECS mapping. Both the accuracy and specificity were better than using the motor-task fMRI only. Especially, for those patients who failed in task fMRI mapping, our method was able to provide accurate mapping as well. Our results also indicate that cortical sensorimotor network pattern is intrinsic and always present during various tasks, which supports the physiological link between the spontaneous and the task-evoked BOLD signals.
Subject(s)
Magnetic Resonance Imaging , Brain Mapping , Epilepsy , Humans , Language , Reproducibility of ResultsABSTRACT
Objective To investigate the effect of the modified and controllable sigmoid colostomy in ostomy operation.Methods Sixty patients were divided into two groups.The control group (30 cases) received extraperitoneal sigrnoid colostomy while the experimental group (30 cases) received modified and controllable sigmoid colostomy.Postoperative complications caused by sigmoid colostomy,artificial anal function,psychological disorder,life quality,and the level of tumor marker between two groups were compared.Results In experimental group,4 patients (13.33％,4/30) at postoperative 6 months and 1 patient (3.33％,1/30) at postoperative 12 months suffered from complications caused by sigmoid colostomy.The incidence rate of complications caused by sigmoid colostomy was higher in control group[30.00％(9/30) and 10.00％(3/30)],but there was no significant difference (P ＞ 0.05).In experimental group,the defecate controllable and times were increased,18 patients (60.00％,18/30) could freedom control defecation,14patients (46.67％,14/30) defecation times ≤3 at postoperative 12 months.But there were 11 patients (36.67％,11/30) and 8 patients (26.67％,8/30) in control group,there was significant difference (P ＜0.05).The rate of human communication disorders,self abasement,anxiety and disappointment in experimental group at postoperative 12 months were significantly lower than those in control group (P ＜ 0.05).The rate of pessimism,loneliness and fear between two groups had no significant difference (P ＞ 0.05).In the evaluation of QLQ-C30 scale,aside from recognition function and financial straits had no significant difference(P ＞ 0.05),others scores in experimental group were significantly better than those in control group (P ＜ 0.05 or ＜ 0.01).In the evaluation of QLQ-C38 scale,the scores in experimental group at postoperative 12 months were significantly better than those in control group (P ＜ 0.01 or ＜ 0.05).At postoperative 12 months,the level of carcinoembryonic antigen,cancer antigen 125 and cancer antigen 199 in experimental group were significantly lower than those in control group (P ＜ 0.05).Conclusion The modified and controllable sigrnoid colostomy has the advantages,less complications,controllable,simple,safe and it is worthy of application more widely in clinical practice.
ABSTRACT
In order to improve bilingual teaching in clinical epidemiology,a multidimensional teaching mode with flexible method was constructed.And it was proposed that based on the student-centered learning,the content of teaching should be adjusted,English should be used logically and clinical courses and practice should be closely connected.The new teaching method was proved successful.
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Objective:To evaluate the efficiency and safety of fraxiparin in the treatment of patients with ACS. Method:137 patients with acute coronary syndrome(ACS)were randomly assigned to fraxiparin treatment and enoxaparin treatment for 7 days.Result:129 cases completed the whole trial and the results were obtained from ITT.The heart death rate was not statistically different between the two groups during the treatment.No Q segment acute myocardial infarction occurred.Both drugs statistically decreased CK CKMB and TnT.There was no significant difference between the two groups regarding these changes.Only two minor adverse reactions occurred and became normal soon after nadroparin withdrew. Conclusion:Fraxiparin and enoxaparin had similar efficiency and safety in the treatment of patients with ACS.
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Objective: To understand the effect of bilingual teaching in the course of clinical epidemiology for the 7-year clinical medical undergraduates.Method: There were totally 45 clinical medical undergraduates selected to respond the questionnaire.The method of Focus Group Discussion had been used in the study.Results:91.11% of the students thought bilingual teaching was necessary for them and 73.33% thought the proportion of English teaching was reasonable,but 68.89% of them were not satisfied with the text book.80% said they could understand the teaching on the whole,but not clearly and deeply enough.86.67% of the students were content with the course.Conclusion:Bilingual teaching could help students to improve their professional English capability and English listening level.The key to the interest of bilingual teaching is teacher.The mode of teaching and text book should be improved.
