[Jaroslav Hladik--a Czech pharmaceutical historian on his jubilee]. / Jaroslav Hladík--ceský farmaceutický historik v jubilejním hodnocení.

Jaroslav Hladík, who on 12. April 2003 would reach the age of 100 years, started his professional career as a pharmacist in different pharmacies, but after certain period of interim activities he became a university teacher Associate Professor for Pharmaceutical History, founded a pharmaceutical museum, published papers on pharmaceutical history, laid the foundations of a centralized pharmaceutical book collections, etc. He was successfully active in several pharmaceutical university institutions in Prague, Brno, and Bratislava. Pharmaceutical history remained his hobby until his death on 1. August 1975. He is remembered as a great positive personality of Czech pharmacy.

[Drug forms as the subject of a dissertation in the historical past of Charles University]. / Lékové formy jako predmet dizertace v historické minulosti Karlovy univerzity.

The "galenical" dissertation which was presented for disputation by Georgius Horcicka at Charles University in 1841 is discussed as far as its content is concerned. The dissertation studies a great number of pharmaceutical dosage forms, many of which are already obsolete, but a certain number of which are still in use in the present time. It is probably one of the first dissertations treating of the given subject.

Fractals also in pharmacokinetics?

Under certain circumstances the time course of drugs and/or metabolites in body fluids and tissues may show a 'fractal pattern', i.e. manifestations of mainly irregular figures having identical or similar structures in their parts as in the whole. This will be demonstrated in this paper by means of just one example, although many more can be found easily in the literature. It appears that the fractal concept may also be useful in pharmacokinetics to describe the complexity of time-concentration curves by an additional parameter, the 'fractal dimension'. A simple principle is proposed for testing the 'self-similarity' which is useful as accompanying evidence of the fractal dimension.

[What is dynamic optimization and how can it be used in quality control?]. / Was ist die dynamische Optimierung und wie lässt sie sich in der Qualitätssicherung anwenden?

By means of an interdisciplinary approach concerning quality problems of tablets an access to the method of dynamic optimization is described. It could be shown that one needs only one equation to understand the basic principles of the application of this method in quality monitoring. This understanding is promoted by graphic methods effectively. Furthermore it is demonstrated that the dynamic optimization can be useful for the organization of quality control when the result of the quality monitoring process depends on the sequence of various tests.