Subject(s)
Gastrointestinal Hemorrhage/complications , Plasmablastic Lymphoma/complications , Rectal Neoplasms/complications , Biopsy , Female , Gastrointestinal Hemorrhage/pathology , Humans , Middle Aged , Plasmablastic Lymphoma/pathology , Rectal Neoplasms/pathology , Rectum/pathology , RecurrenceABSTRACT
INTRODUCTION AND AIMS: Gastric cancer is one of the main causes of cancer worldwide, but there is currently no global screening strategy for the disease. Endoscopy is the screening method of choice in some Asian countries, but no standardized technique has been recognized. Systematic alphanumeric-coded endoscopy can increase gastric lesion detection. The aim of the present article was to compare the usefulness of systematic alphanumeric-coded endoscopy with conventional endoscopy for the detection of premalignant lesions and early gastric cancer in subjects at average risk for gastric cancer. MATERIALS AND METHODS: A cross-sectional, comparative, prospective, randomized study was conducted on patients at average risk for gastric cancer (40-50 years of age, no history of H. pylori infection, intestinal metaplasia, gastric atrophy, or gastrointestinal surgery). Before undergoing endoscopy, the patients had gastric preparation (200mg of oral acetylcysteine or 50mg of oral dimethicone). Conventional chromoendoscopy was performed with indigo carmine dye for contrast enhancement. RESULTS: Fifty consecutive cases (mean age 44.4 ± 3.34 years, 60% women, BMI 27.6 ± 5.82 kg/m2) were evaluated. Endoscopic imaging quality was satisfactory in all the cases, with no differences between methods (p = 0.817). The detection rate of premalignant lesions and early gastric cancer was 14% (6 cases of intestinal metaplasia and one case of gastric adenocarcinoma). Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 100, 95, 80, 100 and 96%, respectively, for systematic alphanumeric-coded endoscopy, and 100, 45, 20, 100, and 52%, respectively, for conventional endoscopy. Lesion detection through systematic alphanumeric-coded endoscopy was superior to that of conventional endoscopy (p = 0.003; OR = 12). CONCLUSION: Both techniques were effective, but systematic alphanumeric-coded endoscopy significantly reduced the false positive rate.
Subject(s)
Adenocarcinoma/diagnostic imaging , Early Detection of Cancer/methods , Gastroscopy/methods , Optical Imaging/methods , Precancerous Conditions/diagnostic imaging , Stomach Neoplasms/diagnostic imaging , Adenocarcinoma/pathology , Adult , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Precancerous Conditions/pathology , Prospective Studies , Risk , Sensitivity and Specificity , Stomach Neoplasms/pathologyABSTRACT
Laparoscopic Nissen fundoplication is currently considered the surgical treatment of choice for gastroesophageal reflux disease (GERD) and its long-term effectiveness is above 90%. Adequate patient selection and the experience of the surgeon are among the predictive factors of good clinical response. However, there can be new, persistent, and recurrent symptoms after the antireflux procedure in up to 30% of the cases. There are numerous causes, but in general, they are due to one or more anatomic abnormalities and esophageal and gastric function alterations. When there are persistent symptoms after the surgical procedure, the surgery should be described as "failed". In the case of a patient that initially manifests symptom control, but the symptoms then reappear, the term "dysfunction" could be used. When symptoms worsen, or when symptoms or clinical situations appear that did not exist before the surgery, this should be considered a "complication". Postoperative dysphagia and dyspeptic symptoms are very frequent and require an integrated approach to determine the best possible treatment. This review details the pathophysiologic aspects, diagnostic approach, and treatment of the symptoms and complications after fundoplication for the management of GERD.
Subject(s)
Fundoplication , Gastroesophageal Reflux/surgery , Postoperative Complications , Fundoplication/methods , Humans , Laparoscopy , Postoperative Complications/diagnosis , Postoperative Complications/physiopathology , Postoperative Complications/therapy , Recurrence , Treatment OutcomeABSTRACT
Primary achalasia is a motor dysfunction of the esophagus with unknown aetiology. We present our results obtained in 39 patients treated by Heller's Cardiomyotomy. The procedure was successful in 92.3% of the cases and when it is performed in conjunction with an antirreflux technique, it offers excellent results with a very low frequency of gastroesophageal reflux symptoms and complications.
