The Neck Disability Index (NDI) and its correlation with quality of life and mental health measures among patients with single-level cervical disc disease scheduled for surgery.

BACKGROUND: The Neck Disability Index (NDI) is widely used as a self-rated disability score in patients with cervical radiculopathy. The purpose of this study was to evaluate whether the NDI score correlated with other assessments of quality of life and mental health in a specific group of patients with single-level cervical disc disease and corresponding radiculopathy. METHODS: One hundred thirty-six patients were included in a prospective, randomized controlled clinical multicenter study on one-level anterior cervical discectomy with arthroplasty (ACDA) versus one-level anterior cervical discectomy with fusion (ACDF). The preoperative data were obtained at hospital admission 1 to 3 days prior to surgery. The NDI score was used as the dependent variable and correlation as well as regression analyses were conducted to assess the relationship with the short form-36, EuroQol-5Dimension-3 level and Hospital Anxiety and Depression Scale. RESULTS: The mean age at inclusion was 44.1 years (SD ±7.0, range 26-59 years), of which 46.3 % were male. Mean NDI score was 48.6 (SD = 12.3, minimum 30 and maximum 88). Simple linear regression analysis demonstrated a significant correlation between NDI and the EuroQol-5Dimension-3 level [R = -0.64, 95 % confidence interval (CI) -30.1- -19.8, p < 0.001] and to a lesser extent between NDI and the short form-36 physical component summary [R = -0.49, 95 % CI (-1.10- -0.58), p < 0.001] and the short form-36 mental component summary [R = -0.25, 95 % CI (-0.47- -0-09), p = 0.004]. Regarding NDI and the Hospital Anxiety and Depression Scale, a significant correlation for depression was found [R = 0.26, 95 % CI (0.21-1.73), p = 0.01]. Multiple linear regression analysis showed a statistically significant and the strongest correlation between NDI and the independent variables in the following order: EuroQol-5Dimension-3 level [R = -0.64, 95 % CI (-23.5- -7.9), p <0.001], short form-36 physical component summary [R = -0.41, 95 % CI (-0.93- -0.23), p = 0.001] and short form-36 mental component summary [R = -0.36, 95 % CI (-0.53- -0.15), p = 0.001]. CONCLUSION: The results from the present study show that the NDI correlated significantly with a different quality of life and mental health measures among patients with single-level cervical disc disease and corresponding radiculopathy.

The Miethke dual switch valve: experience in 169 adult patients with different kinds of hydrocephalus: an open field study.

OBJECT: In spite of the development of approximately 200 different shunt systems within the last 50 years, overdrainage and valve obstructions are still major problems in the current treatment of hydrocephalus. In 1994, a new gravitational valve with different opening pressures (depending upon the patient's posture) and a big contact area to CSF was introduced by Miethke and co-workers (DSV). We report about a single institution's experience in the treatment of 169 adult patients with different kinds of hydrocephalus with this valve. METHODS: We retrospectively reviewed the clinical and radiological data of all patients who were treated with a DSV between 1998 and 2005 at our institution. A telephone interview was perfomed at the end of the study, to determine the overall shunt survival. We analysed the outcome and the shunt-related complications. RESULTS: Among 169 patients with DSV, we had 70 patients with normal pressure hydrocephalus (NPH), 40 patients with communicating hydrocephalus due to SAH, 31 patients with communicating hydrocephalus not due to SAH and 28 patients with occlusive hydrocephalus. We had a rate of shunt responders of 93.2%, an overdrainage rate of 3.2% and no valve obstruction in the whole series. The overall shunt survival was 81% after 82 months (mean follow-up: 47.6 months). All implantations were performed by the whole staff, as well as by residents of the neurosurgical department. DISCUSSION: Among the currently available shunt systems, this series is one with the lowest complication rates due to overdrainage and valve obstructions. In patients with NPH, where low opening pressures are essential, the DSV seems to bear an advantage because of a high drainage rate and, in spite of this, a low rate of overdrainage. Even in patients with relatively high CSF protein content, we did not observe any valve obstruction. This study was an open field analysis providing data about the current complication rates of hydrocephalus treatment with this shunt system, outside of a specialized hydrocephalus team or a prospective study trial. However, this study is a retrospective analysis and a prospective randomized controlled trial is required for the comparison of these valves with other shunt systems, such as programmable and flow-controlled ones is required for the future.