Pharmaceutical Composition for Improving Physical Working Capacity.

For development of a pharmaceutical composition improving physical performance, effects of various drugs and their combinations on forced swimming test performance were studied on laboratory rats. Maximum increase in animal performance was produced by a 3-component composition asparcam+mildronate+metaprote in proportion of 5.0, 10.7, and 14.3 mg/kg, respectively. No changes in blood serum biochemistry and morphological composition of the peripheral blood were detected after single intragastric administration of the composition.

[The clinical and morphological aspects of lichenoid tissue reactions]. / Klinicheskie i morfologicheskie aspekty likhenoidno-tkanevykh reaktsii.

Epidermal basal layer cell vacuolar dystrophy of varying severity was detected in 16 patients with different dermatoses (lichen ruber planus, lupus erythematosus, drug-induced exanthemas, etc.). These changes underlie the lichenoid tissue reactions.

[A case of nevus verrucosus]. / Sluchai borodavchatogo nevusa.

A wart-like nevus in a 49-year-old man, resident of Kaluga Province, is described. The diagnosis has been histologically confirmed.

[Malignant lymphomas of the skin (clinico-morphological parallels)]. / Zlokachestvennye limfomy kozhi (kliniko-morfologicheskie paralleli).

On the basis of clinico-morphological analysis of 104 patients with malignant skin lymphomas (MSL) they are subdivided into two groups: epidermotropic (mycosis fungoides, prolymphocytic and lymphoblastic MSL with sinuous nuclei, histiocytic MSL) and non-epidermotropic (prolymphocytic MSL with roundish nuclei, microlymphoblastic and immunoblastic MSL). The former group differs from the latter by the involvement of the epidermis, with hyperplasia of keratinocytes and the disturbance of their differentiation, penetration of tumour cell into the epidermis and by the composition, type and localization of the proliferate. Epidermotropic MSL were much more frequent, affected younger persons, had a longer duration, more widespread skin involvement with polymorphic eruptions. Non-epidermotropic MSL were characterised by the appearance of single tumours of the skin and early generalization.

[Acne necrotica]. / Nekroticheskie ugri.

A 50-year-old female patient with typical symptoms of acne necrotica is described. The eruptions involved seborrheic areas on the skin of the forehead, conchae of the auricles, nose and nasolabial folds, and presented as nodules covered with serous crusts, necrotic foci, and small stamp cicatrices. Histologic findings confirm the clinical diagnosis. Combined treatment with presocyl and tetracycline was fairly effective.

[Tertiary active syphilis in a patient after a third infection]. / Tretichnyi aktivnyi sifilis u bol'nogo posle tret'ego zarazheniia.

A patient developing tertiary active syphilis after the third infection is described. A swift development of the condition after the infection is noteworthy.

[Chronic lichenoid keratosis]. / Khronicheskii likhenoidnyi keratoz.

This is the first case of chronic lichenoid keratosis described in this country. The clinical picture and histologic findings suggest that this dermatosis be regarded as an atypical variety of lichen ruber planus.

[The significance of epidermal changes in the early diagnosis and development of mycosis fungoides]. / Znachenie izmenenii épidermisa v rannei diagnostike i razvitii gribovidnogo mikoza.

In 47 patients with stage I mycosis fungoides, biopsy of skin has revealed substantial changes in epidermis acanthosis with confluent epidermal processes, focal dystrophy of basal cells, mitoses in various epidermal layers, parakeratotic foci without a granular layer. Histoautoradiographic and immunomorphological studies demonstrated that enhanced proliferative activity of keratinocytes that was more pronounced in stages I and II mycosis fungoides and impaired epidermal differentiation that was predominant in neoplastic stage III underlay the above changes. There was ultrastructural evidence for abnormal epidermal keratinization. It was proposed that epidermal abnormalities made an important contribution to the development of mycosis fungoides.

[Mibelli's porokeratosis]. / Porokeratoz Mibelli.

A 44-year-old patient suffering from porokeratosis of Mibelli for 27 years is described. The eruptions have involved the skin of the buttocks and the upper and lower limb flexor surface. The clinical picture of the disease may be regarded as the classical plaque form. The clinical diagnosis has been confirmed by a characteristic histologic picture with invagination of the corium mass into the epidermis (corniculate plates). Electron microscopy has shown a number of shifts in the epidermis sites adjacent to the corniculate plate and above it. The proliferative activity of the epidermis was enhanced but the keratinization processes round the corniculate plate was unchanged.

[Complex assessment of the proliferation of epidermal and tumor cells in malignant skin lymphoma]. / Kompleksnaia otsenka proliferatsiia épidermal'nykh i opukholevykh kletok pri zlokachestvennykh limfomakh kozhi.

Keratinocyte and tumor cell proliferative activities in skin biopsy specimens of 49 patients with various forms of malignant lymphomas of the skin are analyzed. The mitotic index and 3H thymidine labeled nuclei index in the epidermal and tumor proliferate cells were under study; cytophotometry of the tumor cell DNA was carried out, as well as analysis of correlations of the examined parameters and the patients' life spans. The findings evidence an increase of the keratinocyte proliferative activity in epidermotropic malignant lymphomas of the skin, this pointing to the significance of epidermal abnormalities in the development of this condition.

[Pathomorphology of malignant skin lymphomas]. / Patomorfologiia zlokachestvennykh limfom kozhi.

Clinico-morphologic study of 52 biopsy samples from patients with primary lymphoproliferative skin diseases was performed. Criteria of differential diagnosis of these diseases are suggested based on the differentiation degree of lymphoid cells, their belonging to T and B cell immune systems, and the character of proliferation (poly- or monoclonal). Three morphologic variants of malignant skin lymphoma have been distinguished, (lymphoplasmocytic, prolymphocytic and immunoblastic) all of them being clinically and prognostically different. The so-called "primary reticulosis" of skin is considered as a reactive proliferation of lymphoid cells, that in a number of cases transforms into a malignant lymphoma.