ABSTRACT
The regulatory and adaptive status was determined in 202 healthy subjects by the parameters of the cardiorespiratory synchronism probe. We performed molecular-genetic analysis of polymorphic variants of the main gene of serotonin biosynthesis, tryptophan hydroxylase TPH1 (A218C polymorphism) and TPH2 (G703T polymorphism), and serotonin receptors (HTR2C and HTR2A genes). The association of the regulatory and adaptive status of a subject with the polymorphism of serotonergic mediator system genes was revealed.
Subject(s)
Polymorphism, Single Nucleotide/genetics , Pulmonary Heart Disease/genetics , Adolescent , Adult , Gene Frequency/genetics , Genetic Predisposition to Disease/genetics , Genotype , Humans , Male , Neurotransmitter Agents/metabolism , Receptor, Serotonin, 5-HT2A/genetics , Receptor, Serotonin, 5-HT2C/genetics , Serotonin/metabolism , Tryptophan Hydroxylase/genetics , Young AdultABSTRACT
We studied changes in cerebral and central hemodynamics during active orthostatic load in 26 healthy men aging 20-26 years. Two types of central hemodynamics were revealed: progressive increase in blood pressure throughout the test (type 1) or initial blood pressure increase followed by its decrease with maximum increase in diastolic blood pressure (type 2). The reactions of cerebral hemodynamics to active orthostasis in healthy individuals manifested in reduced cerebral blood flow in the basilar artery. The decrease in blood flow rate in the basilar artery during active orthostasis was associated with vasoconstriction of pial vessels of the vertebrobasilar basin and with the increase in respiratory volume.
