[Indices of lipid metabolism and peroxidation in normal newborn infants]. / Pokazateli lipidnogo obmena i perekisnogo okisleniia lipidov u zdorovykh novorozhdennykh detei.

Studies of lipid metabolism and peroxidation values, carried out in healthy newborns in the town of Irkutsk, have shown that total lipid and triglyceride levels in these newborns over the first ten days of their lives were similar to those in age-matched infants in the European USSR, whereas plasma total cholesterol levels were significantly higher in them as against the newborns in other regions of the country. The studies included measurements of malonic dialdehyde and total antioxidative activity of blood plasma and red cells, of catalase and peroxidase activities, of red cell peroxidation resistance.

[Correlation of electrocoagulogram indices with coagulogram tests]. / Korreliatsiia pokazatelei élektrokoagulogrammy s testami koagulogrammy.

New electrocoagulogram characteristics are suggested. Mathematical analysis has revealed a correlation between some acknowledged electrocoagulogram characteristics and the suggested tests, on the one hand, and plasma heparin tolerance, plasma recalcification time, prothrombin time, fibrinogen content, fibrinolytic activity, and fibrinase activity, on the other. The results of examinations of 76 patients with acute esophagogastroduodenal hemorrhages have confirmed a high informative value of the new characteristics and a possibility of determining the traditional coagulogram values from electrocoagulogram data. This recommends electrocoagulography as a rapid method for the diagnosis of blood coagulation disorders.

[Conservative treatment of acute pancreatitis using intralesional electrophoresis]. / Konservativnoe lechenie ostrogo pankreatita s primeneniem vnutri- tkanevogo élektroforeza.

Experimental data are discussed and experience in complex treatment of 102 patients with acute pancreatitis with the application of intralesional+ electrophoresis is analysed. It was demonstrated in experiments on 90 albino rats that in intralesional+ electrophoresis of radioactive++ 5-fluorouracil (5-FU), its concentration in the pancreas was 2.4-3-fold that in the group of animals in which only intraperitoneal injections of the agent were given. Intralesional+ 5-FU, antibiotic, and contrykal electrophoresis was applied in the clinic in 75 patients with edematous and in 27 patients with destructive pancreatitis. Intralesional+ electrophoresis had a favourable effect on the course of acute pancreatitis, but its efficacy was lower in destructive pancreatitis. Intralesional+ electrophoresis made it possible to lower the general therapeutic doses of these agents and to reduce the number of injections per 24 hours. Three fatal outcomes occurred.

[Lipid peroxidation and the antioxidant system in newborn infants]. / Sostoianie perekisnogo okisleniia lipidov i antiokislitel'noi sistemy u novorozhdennykh.

During measurements of the content of malonic dialdehyde and the total antioxidant activity in blood plasma and red blood cells as well as of their peroxide resistance in healthy neonates, it has been established that in boys and girls the majority of the study parameters did not differ within the first 6 days of life. At the same time in girls, catalase and peroxidase of red blood cells were activated and the total antioxidant activity of blood plasma was increased since the first days after the birth.

[Use of electrocumulation of 5-fluorouracil in treating acute experimental pancreatitis]. / Ispol'zovanie élektrokumuliatsii 5-ftoruratsila pri lechenii ostrogo éksperimental'nogo pankreatita.

The effect of electrocumulation of 5-fluorouracil with the aid of electric field of constant current was studied in rats with experimental acute pancreatitis. 5-Fluorouracil was injected intraperitoneally in a dose of 4.5 mg per 100 g bw. Serum alpha-amylase, trypsin, trypsin inhibitor, lipase and total protease activity in the pancreatic tissue was studied as indicator of the treatment efficacy with 5-fluorouracil electro-cumulation. The levels of serum enzymes as well as the total proteolytic activity in the pancreatic tissue were far more decreased starting from the 3d-6th hour after induction of acute pancreatitis in rats treated by 5-fluorouracil with the aid of electric field of constant current as compared with other groups of rats.