ABSTRACT
We report on eight cases of patients affected by KBG syndrome (KBG stands for the initials of the affected patients in the original report), a rare genetic disease, that we find only in 40 cases mentioned in the scientific literature. In this work we present the minimum diagnostic criteria of diagnosis due to identify the syndrome and a hypothesis of study for the research of the involved factors.
Subject(s)
Abnormalities, Multiple/physiopathology , Child , Child, Preschool , Dental Caries/physiopathology , Female , Humans , Male , Musculoskeletal Abnormalities/physiopathology , Pain/physiopathology , Syndrome , Tooth Diseases/etiologyABSTRACT
The Authors, on the basis of their experience with neoplastic colorectal pathology and after a review of the Literature, report a reappraisal of the problems related to colorectal multiple carcinomas. They emphasize the importance of routine preoperative pancolonoscopy for the identification of possible synchronous tumors (both benign and malignant) and periodic endoscopic follow-up (ideally a life-long one) for the detection and removal of all adenomatous polyps as well as early stage metachronous carcinomas, especially for patients with HNPCC. Besides, they stress the importance of sensibilization of the population about the heritability of colorectal carcinomas.
Subject(s)
Adenocarcinoma , Colorectal Neoplasms , Neoplasms, Multiple Primary , Neoplasms, Second Primary , Adenocarcinoma/mortality , Adenocarcinoma/pathology , Adenocarcinoma/surgery , Adenocarcinoma, Mucinous/mortality , Adenocarcinoma, Mucinous/pathology , Adenocarcinoma, Mucinous/surgery , Adenoma/pathology , Adenoma, Villous/pathology , Adult , Aged , Aged, 80 and over , Colectomy , Colon/pathology , Colonic Polyps/pathology , Colorectal Neoplasms/mortality , Colorectal Neoplasms/pathology , Colorectal Neoplasms/surgery , Female , Follow-Up Studies , Humans , Liver Neoplasms/secondary , Male , Middle Aged , Neoplasms, Multiple Primary/mortality , Neoplasms, Multiple Primary/pathology , Neoplasms, Multiple Primary/surgery , Neoplasms, Second Primary/mortality , Neoplasms, Second Primary/pathology , Neoplasms, Second Primary/surgery , Prognosis , Rectum/pathology , Time FactorsABSTRACT
In the last 3 years, 300 consecutive patients (110 men, 190 women) were treated for gallstone disease using either traditional open surgery or the video laparoscopic approach. The relative clinical data and results were compared and analysed. The Authors conclude that video laparoscopy presents a number of advantages such as minor costs, reduced pain, quick return to work, compared to traditional surgery, especially when correctly indicated.
Subject(s)
Cholecystectomy, Laparoscopic , Cholecystectomy , Cholelithiasis/surgery , Cholangiography , Cholecystectomy/adverse effects , Cholecystectomy, Laparoscopic/adverse effects , Cholelithiasis/diagnostic imaging , Evaluation Studies as Topic , Female , Humans , Male , Video RecordingABSTRACT
Ninety-eight consecutive patients with ampullary and periampullary carcinoma diagnosed between 1983-1993 were studied retrospectively. Among these patients, 66 had a carcinoma of the head of the pancreas, 10 a carcinoma of the papilla of Vater, 8 a carcinoma of the duodenum, and 14 a carcinoma of the distal common bile duct. Resectability rate ranged from 12% to 90% according to the tumor location and histologic type. Palliative procedures such as laparotomy, biopsy and bilio-digestive bypasses were performed in 27 patients. Curative resections were performed in 24 cases: 20 pancreatoduodenectomies, 2 total pancreatectomies, 1 duodenectomy, 1 common bile duct resection. The results of the surgical treatment as well as mortality and morbidity rates were compared with those of different and larger series.
Subject(s)
Ampulla of Vater/surgery , Common Bile Duct Neoplasms/surgery , Adult , Aged , Aged, 80 and over , Ampulla of Vater/pathology , Common Bile Duct Neoplasms/mortality , Common Bile Duct Neoplasms/pathology , Female , Humans , Male , Middle Aged , Retrospective StudiesABSTRACT
A reappraisal of the results obtained after potentially curative resection for rectal cancer compared with "historical" results is reported. An increase of the overall survival rates was registered as well as a corresponding lowering of the pelvic recurrences: 4.54% in the group of patients with a-two-year follow up. As for relapse surgery, however, reviewing the series from January 1991 to December 1994, the results are still poor because relapses were not resectable in 85.7% of the cases.
Subject(s)
Neoplasm Recurrence, Local/epidemiology , Rectal Neoplasms/epidemiology , Rectal Neoplasms/surgery , Adult , Aged , Aged, 80 and over , Female , Humans , Incidence , Italy/epidemiology , Lymph Node Excision , Male , Middle Aged , Neoplasm Recurrence, Local/mortality , Neoplasm Recurrence, Local/pathology , Neoplasm Recurrence, Local/surgery , Neoplasm Staging , Rectal Neoplasms/mortality , Rectal Neoplasms/pathology , ReoperationABSTRACT
In the last 5 years 25 patients (11 men, 14 women) with carcinoma of the extrahepatic biliary duct were studied. The most frequent localization of the carcinoma was the hepatic hilum. D.C.P. according to Whipple was possible only in one patient, while in 20 patients a palliative approach with external and internal biliary derivations was the choice. In the remaining 4 patients an explorative laparotomy with biopsy was performed. It is concluded that palliative resection allows for a better quality of life.
