ABSTRACT
64 patients with lung tuberculosis were operated on after chemotherapy course using regimens I and III. 69 patients were operated on after the treatment by DOTS/PLUS protocol. The obtained operative material was bacteriologically tested. Bacterial growth in samples of patients treated with DOTS/PLUS protocol caused by multydrug resistance of mycobacteria. The noncoinsidence of the drug resistance spectrum in sputum and resected samples was registered in 33% of patients treated by DOTS/ PLUS protocol and 25% of patients, treated by using regimens I and III.
Subject(s)
Antitubercular Agents/therapeutic use , Clinical Protocols/standards , Mycobacterium tuberculosis , Perioperative Care/methods , Tuberculosis, Multidrug-Resistant , Tuberculosis, Pulmonary , Adult , Bacteriological Techniques/methods , Drug Resistance, Multiple, Bacterial , Female , Humans , International Cooperation , Intraoperative Care/methods , Lung/microbiology , Lung/pathology , Male , Mycobacterium tuberculosis/drug effects , Mycobacterium tuberculosis/isolation & purification , Mycobacterium tuberculosis/pathogenicity , Patient Selection , Perioperative Care/standards , Pneumonectomy/methods , Sputum/microbiology , Treatment Outcome , Tuberculosis, Multidrug-Resistant/drug therapy , Tuberculosis, Multidrug-Resistant/microbiology , Tuberculosis, Multidrug-Resistant/pathology , Tuberculosis, Multidrug-Resistant/surgery , Tuberculosis, Pulmonary/drug therapy , Tuberculosis, Pulmonary/microbiology , Tuberculosis, Pulmonary/pathology , Tuberculosis, Pulmonary/surgeryABSTRACT
The paper presents the results of a combined biochemical study of 111 patients suffering from recently diagnosed pulmonary tuberculosis combined with chronic opisthorchiasis (main group) and 36 tuberculosis patients without infestation (control group). It was established that the mixed abnormality was significantly more often accompanied by hypoproteinemia and hypoalbuminemia. The thymol and mercury-chloride sublimate tests produced positive results in 22.5 and 9.0% of the main group patients, respectively. Increased bilirubin content and alanine and aspartate aminotransferase activities were registered in both groups of patients only during medical treatment. Thus, the fact of altered protein forming function of liver in patients with tuberculosis combined with chronic opisthorchiasis has been established, which may be due both to tuberculosis infection and the Opisthorchis invasion. Insignificant hepatic protein-forming dysfunctions are not contraindications for long-term tuberculosis therapy.
