Subject(s)
Adjuvants, Immunologic/adverse effects , Drug Hypersensitivity/etiology , Eczema/drug therapy , Hypersensitivity, Delayed/chemically induced , Peptides/adverse effects , Thymus Extracts/adverse effects , Adjuvants, Immunologic/therapeutic use , Adult , Drug Hypersensitivity/therapy , Eczema/immunology , Humans , Hypersensitivity, Delayed/therapy , Immunity, Cellular/drug effects , Male , Peptides/therapeutic use , Thymus Extracts/therapeutic useABSTRACT
A total of 113 patients with disseminated psoriasis were examined. Roentgenograms of the joints have shown signs of osteoarthrosis deformans in 85.7 percent of them. Involvement of the joints of the soles was recorded in 80.5 percent, of the hands in 58.3 percent, of iliosacral articulation in 33.3 percent of patients. These shifts were in line with clinico-laboratory changes characteristic of psoriatic arthropathy in less than one third of the examinees. Rheovasography of the upper and lower limbs has revealed the spastic asthenic syndrome in all the examinees; this syndrome most frequently manifested by increased tone and decreased pulse blood content of the vessels. A direct correlation between x-ray changes in the joints and disordered vascular tone of the limbs has been revealed. The detected elevation of blood lipid level in psoriasis patients as a rule did not correlate with impaired blood supply to the upper and lower limbs. These findings bring the authors to a conclusion that in psoriasis not only the skin, but the bone-and-joint and vascular systems are involved in the process, as are the metabolic processes.
Subject(s)
Bone and Bones/physiopathology , Joints/physiopathology , Psoriasis/blood , Vascular Resistance , Adolescent , Adult , Aged , Arm/blood supply , Arthritis, Psoriatic/blood , Arthritis, Psoriatic/diagnosis , Arthritis, Psoriatic/physiopathology , Chronic Disease , Female , Humans , Leg/blood supply , Lipids/blood , Male , Middle Aged , Psoriasis/diagnosis , Psoriasis/physiopathologyABSTRACT
Ultrasonic scanning of the digestion organs, carried out in 35 patients with eczema and 20 ones with diffuse neurodermatitis have revealed abnormalities of the liver echostructure in 60% of patients with eczema and in 50% of neurodermatitis patients; abnormal gallbladder echostructure in 65.7% of eczema patients and in 25% of neurodermatitis patients; disturbed echostructure of the pancreas in 34.3% of eczema patients and in 5% of neurodermatitis patients. These abnormalities have not been associated with clinical shifts as a rule. Liver dysfunction and leukocytosis in the B bile have been detectable only in the patients with abnormal echostructure of the organs; these shifts showed a tendency to normalization over the course of treatment irrespective of the skin status. During rehabilitation after discharge from hospital such patients should be kept on diets and administered drug therapy, aimed at the prevention of the digestive organs diseases.