1.
Brain Res
; 631(1): 147-50, 1993 Dec 17.
Article
in English
| MEDLINE
| ID: mdl-8298987
ABSTRACT
The present study determined whether [3H]nisoxetine binding to norepinephrine transporter sites would be altered uniformly throughout the locus coeruleus in Alzheimer's disease. A significant decrease (P < 0.01) in [3H]nisoxetine binding was seen in the mid and caudal regions but not in the rostral region of the locus coeruleus. The loss of [3H]nisoxetine binding to norepinephrine transporter sites may be attributed to a loss of norepinephrine transporter sites located on terminals of noradrenergic neurons in the locus coeruleus in Alzheimer's disease.