ABSTRACT
The subjects of the study were 221 patients with cicatrical esophageal strictures. 62 (28.5%) patients had peptic strictures, and 159 (71.9%)--post-burn strictures. 67 (30.3%) patients underwent esophageal resection with one-stage intrapleural esophagoplasty with the stomach, 152 (68.8%) patients--gullet bougienage in combination with surgical intervention or as an only treatment. The study revealed 8 cases of squamous cell carcinoma in patients with post-burn strictures, and 3 cases of squamous cell carcinoma in patients with peptic strictures. In 2 cases the researchers found early stage of esophageal cancer (verrucose carcinoma)--in 1 patient with post-burn stricture and 1 patient with peptic stricture. The results suggest an important role of chronic gastroesophageal reflux in the oncogenesis of esophageal squamous cell carcinoma in patients with post-burn and peptic strictures.
Subject(s)
Burns, Chemical/complications , Esophageal Neoplasms/etiology , Esophageal Stenosis/complications , Esophagitis, Peptic/complications , Esophagus/injuries , Gastroesophageal Reflux/complications , Adult , Biopsy , Burns, Chemical/pathology , Carcinoma, Verrucous/etiology , Carcinoma, Verrucous/pathology , Chronic Disease , Cicatrix , Disease Progression , Esophageal Neoplasms/pathology , Esophageal Stenosis/pathology , Esophagitis, Peptic/pathology , Female , Gastroesophageal Reflux/pathology , Humans , Male , Retrospective StudiesABSTRACT
In this paper we present the results of radiotherapy in a case of severe macroglossy in a 14-year-old girl. Before radiotherapy, two surgical interventions (so-called wedge formed resections) had been performed. In spite of these surgical procedures the tongue continued growing. The tongue remained hypertrophic and became more voluminous. Speach, breathing and nourishment became quite impossible, and salivation was very intensive and insupportable. The patient had to be nourished by a nasal tube. To avoid suffocation, tracheotomy had to be performed. Histopathological finding of the operated tissue of the tongue was: Striated musculature and granulations. During radiotherapy, amelioration of symptoms occurred after the first sessions. Total dose by two series of irradiation was 6650 r skin dose under orthovoltage conditions. The final good effect could be observed not earlier than 8 months after radiotherapy.
