ABSTRACT
Fifty-nine outpatients affected by cervico-vaginal dystrophy with manifest symptoms were included in the study. Following initial tests (colposcopy with Schiller's test, colpocytological test, analysis of symptoms), a cycle of treatment was commenced using the insertion of a vaginal pessary of Polydeoxy-ribonucleotide (PDRN) in the evening for 20 days. A control on day 28 revealed a marked improvement of the symptoms together with a positive evolution of objective tests. During the 10th week after the end of therapy, both subjective and objective findings tended to confirm the relapse towards pre-treatment conditions.
Subject(s)
Uterine Cervical Diseases/therapy , Vaginal Diseases/therapy , Administration, Topical , Aged , Female , Humans , Middle Aged , Pessaries , Polydeoxyribonucleotides/administration & dosage , Recurrence , Uterine Cervical Diseases/diagnosis , Uterine Cervical Diseases/pathology , Vaginal Diseases/diagnosis , Vaginal Diseases/pathology , Vaginal SmearsABSTRACT
A group of 11 hirsute women with elevated total plasma testosterone (no ovaric neoplasia detectable) was studied by dexamethasone suppression test. Suppression to within normal limits was in 5 patients by dexamethasone alone. After a 5 month continuous therapy ovulation was restored and hirsutism reduced. Suppression was obtained in the other 6 patients only with estroprogestins. These results suggest an interesting hypothesis: hypertestosteronemias related to anovulation might be divided in two classes, the first one in which testosterone is synthetized from adrenal prehormones, the second one in which testosterone is synthetized from acetate.
