ABSTRACT
Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population.
Subject(s)
Leukoplakia, Oral/drug therapy , Lichen Planus, Oral/drug therapy , Mouth Mucosa/pathology , Naphthoquinones/therapeutic use , Oral Ulcer/drug therapy , Adult , Aged , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Biopolymers/therapeutic use , Drugs, Chinese Herbal/therapeutic use , Female , Humans , Inflammation/drug therapy , Male , Methylcellulose/analogs & derivatives , Methylcellulose/therapeutic use , Middle AgedABSTRACT
Structural reorganization of the buccal mucosa and changes in proliferative activity of epitheliocytes in typical and erosive ulcerative lichen planus were studied. The most manifest diagnostically significant pathomorphological signs of lichen planus of the buccal mucosa are described: acanthosis, granulosis, parakeratosis, lymphocytic infiltration of the lamina propria, and edema. The most pronounced morphological changes and higher index of epitheliocyte proliferative activity (by expression of Ki-67) are characteristic of the erosive ulcerative form of the disease.
