[Effect of solcoseryl on oxygen metabolism and growth of experimental tumors]. / Vliianie solkoserila na kislorodnyi obmen i techenie opukholevogo protsessa v éksperimente.

Antihypoxant and antitumour properties of solcoseryl were studied on intact and tumour-bearing rats and mice. By the polarographic method it is found that solcoseryl increases the oxygen metabolism only in animal hypoxic tissues and improves, probably, energy production of their mitochondria. On many tumour strains it is shown that the injections of solcoseryl decelerate the growth of some tumours, inhibit the metastatic process and produce no toxic effect on the animals.

[Oxygen metabolic characteristics in the tumor process]. / Osobennosti kislorodnogo obmena pri opukholevom protsesse.

The data available in literature and results of the authors, own investigations on the oxygen metabolism during the appearance and development of the tumour process are presented. The important role of biological oxidation disorders in cell malignancy is discussed. The appearance and development of malignant tumours occur against a background of tissues hypoxia. Severe hypoxia and anoxia are observed constantly in the tumour tissue. Some mechanisms of hypoxia development and cell respiration reduction in malignant tumours are considered. Necessity of methods and drugs searching (antihypoxic agents and antioxidants) for correction of oxygen homeostasis disturbances and increase of antitumour resistance of the organism is substantiated.

[Oxygen tension in the tissues of animals during the process of malignant tumor growth]. / Napriazhenie kisloroda v tkaniakh zhivotnykh v protsesse rosta zlokachestvennykh opukholei

It has been shown polarographically that the oxygen supply and consumption in transplantable Heren carcinoma and normal tissues of the tumor organism are reduced as compared with such indices in intact animals. As the tumor grows, oxygen tension in normal tissues is gradually lowered both under normal conditions and oxygen ventilation, while the time of its consumption by tissues is longer. Such changes in tissues pO2 are not observed in subcutaneous transplantation of muscle tissue suspension in animals and also in transplantable tumor resorption.