ABSTRACT
Thinking often entails interacting with cognitive tools. In many cases, notably design, the predominant tool is the page. The page allows externalizing, organizing, and reorganizing thought. Yet, the page has its own properties that by expressing thought affect it: path, proximity, place, and permanence. The effects of these properties were evident in designs of information systems created by students Paths were interpreted as routes through components. Proximity was used to group subsystems. Horizontal position on the page was used to express temporal sequence and vertical position to reflect real-world spatial position. The permanence of designs on the page guided but also constrained generation of alternative designs. Cognitive tools both reflect and affect thought.
Subject(s)
Cognition/physiology , Mental Processes/physiology , Computer Systems , Creativity , Data Interpretation, Statistical , Equipment Design , Female , Humans , Information Systems , Male , Orientation , Web Browser , Young AdultABSTRACT
Coronary vascular reserve is impaired during acute cellular rejection of the orthotopically transplanted heart, but changes in the peripheral vasculature during rejection have not been well described. To investigate whether peripheral vascular compensatory mechanisms are preserved after orthotopic heart transplantation (OHT), we longitudinally observed systemic vascular resistance (SVR) and cardiac output (CO) during acute cellular rejection. CO decreased during high-grade acute cellular rejection, and maintenance of mean arterial pressure was achieved by increases in SVR, and these changes did not return to baseline until several months after histologic resolution of rejection.
