ABSTRACT
[Bischofit-based ointment was found to produce a stimulatory effect on the regeneration processes in wounds and the biomechanical properties of scar tissues in both infected and uninfected wounds]
Subject(s)
Cicatrix/drug therapy , Magnesium Compounds/pharmacology , Minerals/pharmacology , Staphylococcal Infections/drug therapy , Staphylococcus aureus , Wound Infection/drug therapy , Wounds and Injuries/drug therapy , Animals , Cicatrix/microbiology , Cicatrix/physiopathology , Male , Ointments , Rats , Skin/microbiology , Skin/physiopathology , Staphylococcal Infections/physiopathology , Wound Healing/drug effects , Wound Infection/physiopathology , Wounds and Injuries/microbiology , Wounds and Injuries/physiopathologyABSTRACT
We compared gastroprotective characteristics of synthetic prostaglandin E1 misoprostol and amino acid taurine on rat model of monochloramine injury to the gastric mucosa. Both substances exhibited a pronounced gastroprotective effect.
Subject(s)
Chloramines/toxicity , Misoprostol/pharmacology , Stomach Ulcer/chemically induced , Stomach Ulcer/prevention & control , Taurine/pharmacology , Animals , Female , Male , RatsABSTRACT
This study was designed as a comparative experimental analysis of the gastroprotective effects of two H2-blocking agents--famotidine and benzimidazole compound 64--on the model rat stomach Helicobacter-like mucous lesions. Both substances demonstrated dose-dependent gastroprotective effects both on the macro- and microscopic levels. ED50 made up 21.8 mg/kg and 13.5 mg/kg, respectively.
Subject(s)
Famotidine/therapeutic use , Gastric Mucosa/drug effects , Helicobacter Infections/complications , Histamine H2 Antagonists/therapeutic use , Stomach Ulcer/drug therapy , Animals , Disease Models, Animal , Female , Gastric Mucosa/pathology , Male , Necrosis , Rats , Stomach Ulcer/etiology , Stomach Ulcer/pathologyABSTRACT
20 uteri, 80 placentas and the hearts of 66 normal fetuses from rheumatic mothers have been studied. Exacerbations of rheumatism were observed in some mothers during pregnancy. Sclerosis with enhanced synthesis of collagen type I, III, IV, V and fibronectin was observed in ECM when rheumatism during the pregnancy was not active. Activation of rheumatism during the pregnancy was followed by disturbances of synthesis of interstitial and membrane collagen types, alteration of stromal-parenchymatous relations and development of dyschronosis in the placenta and fetal heart. The study of the heart from children aged 3 months-14 years showed a long-term effect of maternal rheumatism.
Subject(s)
Extracellular Matrix/immunology , Myocardium/immunology , Placenta/immunology , Prenatal Exposure Delayed Effects , Rheumatic Diseases/immunology , Uterus/immunology , Adolescent , Adult , Child , Child, Preschool , Collagen/immunology , Extracellular Matrix/pathology , Female , Fibronectins/immunology , Heart/embryology , Humans , Immunohistochemistry , Infant , Myocardium/pathology , Placenta/pathology , Pregnancy , Rheumatic Diseases/congenital , Rheumatic Diseases/pathology , Uterus/pathologyABSTRACT
38 adenomatous polyps, 42 villous polyps with varying degree of proliferation and epithelial dysplasia, 34 polyps with preinvasive cancer components and 44 polyps containing invasive cancer elements were examined microspectrophotometrically. The analysis established an increased level of epithelial cells with ploidy varying 3c-5c to be a characteristic feature of the initial stages of malignant transformation of rectal polyps. The invasive cancer had similar peculiarities.
