[Ultrastructure of the myocardium in patients with cardiac pathology complicated by diabetes mellitus]. / Ul'trastruktura miokarda bol'nykh s patologiei sedtsa oslozhnennoi sakharnym diabetom.

Myocardial ultrastructure of patients with diabetes mellitus and cardiomyopathy and those with coronary heart disease was practically similar. Alterations of the ultrastructural organization concerned mainly the mitochondria and structures responsible for the contraction. Disturbances of the microcirculation in diabetes were so much pronounced that the presence of the large arteries stenosis did not enhance the alterations in the cardiomyocytes: supply of oxygen and substrates to the working cells was severely changed because of the arteriolar spasm as well as capillaries obturation due to adhesion of blood cells to the endothelial lining and low level of micropinocytosis in the endotheliocytes.

[Affection of myocardium in diabetes mellitus]. / Porazheniia miokarda pri sakharnom diabete.

Echocardiography was performed in 67 patients with compensated diabetes mellitus (DM) type I and II. No signs of cardiovascular failure were noted. 20 patients have undergone myocardial scintigraphy. The patients were found to have hyperkinetic central hemodynamics resultant in DM type I from tachycardia, high rate of circulatory shortening of myocardial fibers, in DM type II from compensatory myocardial hypertrophy. In both diabetic types the function of myocardial relaxation was deteriorated as indicated by increased end diastolic volume and slow left ventricular relaxation. This evidences for initial cardiac failure. Myocardial scintigraphy registered perfusion defects in all the examinees, more profound in diabetes mellitus type II. The above findings explain the existence of marked coronarogenic and metabolic myocardial defects in DM.