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1.
Crit Rev Anal Chem ; : 1-26, 2023 Dec 28.
Article in English | MEDLINE | ID: mdl-38153424

ABSTRACT

Molecularly imprinted polymer (MIP)-based electrochemical sensors have been extensively researched due to their higher sensitivity, quick response, and operational ease. To develop more advanced sensing devices with enhanced properties, MIPs have been integrated with two-dimensional (2D) layered materials such as transition metal dichalcogenides (TMDs) and MXenes. These 2D materials have unique electronic properties and an extended surface area, making them promising sensing materials that can improve the performance of MIPs. In this review article, we describe the methods used for the synthesis of TMDs and MXenes integrated MIP-based electrochemical sensors. Furthermore, we have provided a critical review of a wide range of analytes determined through the application of these electrochemical sensors. We also go over the influence of TMDs and MXenes on the binding kinetics and adsorption capacity which has enhanced binding recognition and sensing abilities. The combination of TMDs and MXenes with MIPs shows promising synergy in the development of highly efficient recognition materials. In the future, these sensors could be explored for a wider range of applications in environmental remediation, drug delivery, energy storage, and more. Finally, we address the challenges and future perspectives of using TMDs and MXenes integrated MIPs. We conclude with a focus on future development and the scope of integrating these materials in sensing technology.

2.
Int J Biol Macromol ; 249: 126024, 2023 Sep 30.
Article in English | MEDLINE | ID: mdl-37506798

ABSTRACT

In this work, a simple and facile method was developed to achieve controlled oxidation and enhance the surface area of MXene nanosheets and their utilization in the efficient sensing of ascorbic acid (AA or vitamin C). After etching of MAX phase to MXene via the MILD technique, controlled flash oxidation was carried out in the open air environment for 1.5 h, followed by flocculation of oxidized MXene nanosheets by using H2SO4, consequently achieving crumpled MXene possessing anatase phase, porosity, and improved surface area as revealed and confirmed by SEM, TEM, Raman, and BET analysis results. The as-prepared crumpled MXene was coated over a glassy carbon electrode (GCE) and used to determine AA successfully via cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) with a linear concentration range of 300 µM to 0.005 µM with a detection limit (LOD) of 2 nM (2.8 % RSD and S/N = 3). The developed electrochemical sensor was used to determine the AA in various actual samples such as juice, urine, serum, and erythrocytes spiked with AA with excellent recoveries in the 94-103 % range. The sensor also demonstrated excellent reproducibility (~1 % RSD for five repetitive assays) and a shelf life of nearly one month with a negligible decrease in response. Furthermore, it lost only 10 % of its response for the next ten days. It also showed satisfactory selectivity toward AA in the presence of other similar compounds, including uric acid (UA), dopamine (DA), and glucose.


Subject(s)
Ascorbic Acid , Graphite , Ascorbic Acid/chemistry , Reproducibility of Results , Electrochemical Techniques/methods , Dopamine/analysis , Electrodes , Graphite/chemistry
3.
Biosensors (Basel) ; 13(6)2023 Jun 06.
Article in English | MEDLINE | ID: mdl-37366990

ABSTRACT

The identification of the target molecule is required for rapid and reliable clinical diagnosis and disease monitoring [...].


Subject(s)
Biosensing Techniques , Nanostructures
4.
Environ Sci Pollut Res Int ; 30(16): 45528-45554, 2023 Apr.
Article in English | MEDLINE | ID: mdl-36809626

ABSTRACT

Urbanization and a massive population boom have immensely increased the solid wastes (SWs) generation and are expected to reach 3.40 billion tons by 2050. In many developed and emerging nations, SWs are prevalent in both major and small cities. As a result, in the current context, the reusability of SWs through various applications has taken on added importance. Carbon-based quantum dots (Cb-QDs) and their many variants are synthesized from SWs in a straightforward and practical method. Cb-QDs are a new type of semiconductor that has attracted the interest of researchers due to their wide range of applications, which include everything from energy storage, chemical sensing, to drug delivery. This review is primarily focused on the conversion of SWs into useful materials, which is an essential aspect of waste management for pollution reduction. In this context, the goal of the current review is to investigate the sustainable synthesis routes of carbon quantum dots (CQDs), graphene quantum dots (GQDs), and graphene oxide quantum dots (GOQDs) from various types SWs. The applications of CQDs, GQDs, and GOQDs in the different areas are also been discussed. Finally, the challenges in implementing the existing synthesis methods and future research directions are highlighted.


Subject(s)
Graphite , Quantum Dots , Carbon , Solid Waste
5.
Biosensors (Basel) ; 12(12)2022 Dec 01.
Article in English | MEDLINE | ID: mdl-36551073

ABSTRACT

Over the last decades, molecularly imprinted polymers (MIPs) have emerged as selective synthetic receptors that have a selective binding site for specific analytes/target molecules. MIPs are synthetic analogues to the natural biological antigen-antibody system. Owing to the advantages they exhibit, such as high stability, simple synthetic procedure, and cost-effectiveness, MIPs have been widely used as receptors/sensors for the detection and monitoring of a variety of analytes. Moreover, integrating electrochemical sensors with MIPs offers a promising approach and demonstrates greater potential over traditional MIPs. In this review, we have compiled the methods and techniques for the production of MIP-based electrochemical sensors along with the applications of reported MIP sensors for a variety of analytes. A comprehensive in-depth analysis of recent trends reported on picomolar (pM/10-12 M)) and beyond picomolar concentration LOD (≥pM) achieved using MIPs sensors is reported. Finally, we discuss the challenges faced and put forward future perspectives along with our conclusion.


Subject(s)
Molecular Imprinting , Molecularly Imprinted Polymers , Polymers/chemistry , Limit of Detection , Molecular Imprinting/methods
6.
Biosens Bioelectron ; 215: 114509, 2022 Nov 01.
Article in English | MEDLINE | ID: mdl-35940005

ABSTRACT

Despite their high analytical performance, conventional analytical biosensor devices are usually difficult to handle, time-consuming, bulky and expensive. As a result, their applications remain restricted to resource-limited environments. In particular, the transportation of conventional analytical equipment is challenging for the proper in-situ point of need (PON)/point of care (POC) detection of biomolecules. In this context, smartphones, the most widely utilized cutting-edge mobile gadgets, continue to be a favored option because of their ease of portability and revolutionary sensing capabilities. On the other hand, aptamers are molecular recognition units consisting of nucleic acids with highly sensitive and selective recognition capabilities towards their respective targets. The coupling of smartphones with aptamers have led the development of advanced, user-friendly, portable, and cost-effective in-situ PON/POC biosensors for the detection of biomolecules. Such sensors are well-suited for a variety of applications, including food safety, environmental monitoring, and disease diagnostics. Herein, for the first time, achievements made between 2017 and 2022 in the concept and design of the smartphone-enabled aptasensors for biosensing applications are reviewed. The review covers different fabrication strategies and the discussion of several operating systems, underlying programs, and related software. At the end, the important merits, challenges, and future prospects of smart phone-driven aptasensors are presented. This report intends to assist scientists and engineers in comprehending the fabrication of smartphone-based aptasensors and their underlying sensing principles, as well as stimulating the future developments in the direction of affordable, portable, simple, and readily available sensing devices.


Subject(s)
Aptamers, Nucleotide , Biosensing Techniques , Point-of-Care Systems , Smartphone
7.
Crit Rev Anal Chem ; 52(4): 848-864, 2022.
Article in English | MEDLINE | ID: mdl-33108217

ABSTRACT

MXene, a novel class of 2-dimensional transition metal carbides has evolved as a promising material for various applications owing to its outstanding characteristics such as hydrophilicity, high electrical conductivity, surface area, and attractive topological structure. MXenes can form dispersion in common solvents and constitute composite with other nanomaterials, which can be utilized as effective transducers for molecular sensing. MXene-modified support materials, thus provide an intriguing platform for immobilization of target molecules onto their surface. The literature reveals that it has been increasingly utilized in the sensing of diverse types of analytes including glucose, pharmaceuticals, metals and dyes, cancer markers, pesticides, neurotransmitters, small valuable molecules, and so on. In this review, we summarize the recent updates in the MXene modified materials for sensing. For the convenience of our audience, we have distributed the analytes into categories and discussed them comprehensively. Not only we present the synthesis approach, electrochemical properties and surface chemistry of MXenes but also discussed briefly the current challenges and an outlook for future research in the related area.


Subject(s)
Nanostructures , Pesticides , Transition Elements , Metals , Nanostructures/chemistry , Organic Chemicals
8.
Biosensors (Basel) ; 11(3)2021 Mar 21.
Article in English | MEDLINE | ID: mdl-33801007

ABSTRACT

The molecular imprinting polymers (MIPs) have shown their potential in various applications including pharmaceuticals, chemical sensing and biosensing, medical diagnosis, and environmental related issues, owing to their artificial selective biomimetic recognition ability. Despite the challenges posed in the imprinting and recognition of biomacromolecules, the use of MIP for the imprinting of large biomolecular oragnism such as viruses is of huge interest because of the necessity of early diagnosis of virus-induced diseases for clinical and point-of-care (POC) purposes. Thus, many fascinating works have been documented in which such synthetic systems undoubtedly explore a variety of potential implementations, from virus elimination, purification, and diagnosis to virus and bacteria-borne disease therapy. This study is focused comprehensively on the fabrication strategies and their usage in many virus-imprinted works that have appeared in the literature. The drawbacks, challenges, and perspectives are also highlighted.


Subject(s)
Biosensing Techniques , Molecular Imprinting , Viruses , Biomimetics , Humans , Polymers , Virus Diseases/diagnosis
9.
Crit Rev Anal Chem ; 51(7): 609-618, 2021.
Article in English | MEDLINE | ID: mdl-32336109

ABSTRACT

Microbial contaminations and infections are hazardous and pose crucial concerns for humans. They result in severe morbidity and mortality around the globe. Even though dish-culturing, polymerase chain reaction (PCR), an enzyme-linked immunosorbent assay (ELISA) exhibits accurate and reliable detection of bacteria but these methods are time-consuming, laborious, and expensive. This warrants early detection and quantification of bacteria for timely diagnosis and treatment. Bacteria imprinting ensures a solution for selective and early detection of bacteria by snagging them inside their imprinted cavities. This review provides an insight into MIPs based bacterial detection strategies, challenges, and future perspectives.


Subject(s)
Molecular Imprinting , Bacteria/genetics , Enzyme-Linked Immunosorbent Assay , Humans
10.
Talanta ; 210: 120669, 2020 Apr 01.
Article in English | MEDLINE | ID: mdl-31987212

ABSTRACT

Cancer is the one of the fatal and dreaded disease responsible for huge number of morbidity and mortality across the globe. It is expected that the global burden will increase to 21.7 million fresh cancer cases as compared to present estimate of 18.1 million cancer cases in addition to nearly 9.6 million cancer deaths worldwide. In response to cancerous or certain benign conditions; specific type of tumor or cancer markers (biomarkers) are produced at much higher levels which are secreted into the urine, blood, stool, tumor or other tissues. Therefore, the efficient and early detection of cancer biomarkers is necessary which can offer a reliable way for cancer patient screening and diagnosis. This process not only helps in the evaluation of pathogenic processes but also the prognosis of different cancers and pharmacological responses to therapeutic interventions are secured. Over the past several years, electrochemical detection methods have proved to be the most attractive methods among many, due to the advantages, such as simple instrumentation, portability, low cost and high sensitivity. Furthermore, the modifications of these electrochemical immunosensors by utilizing various types of nanomaterials enable these systems to detect trace amount of target tumor markers. Hence, herein, we intend to review the selective works on electrochemical detection of various biomarkers using wide range of nanomaterials with a particular focus on graphene.


Subject(s)
Biomarkers, Tumor/analysis , Biosensing Techniques , Electrochemical Techniques , Graphite/chemistry , Neoplasms/diagnostic imaging , Humans
11.
Biosens Bioelectron ; 140: 111330, 2019 Sep 01.
Article in English | MEDLINE | ID: mdl-31150981

ABSTRACT

Herein, we propose a facile chemical reduction method to synthesize the molybdenum carbide (Mo2C) nanoparticles and its application for the electrochemical detection of folic acid (FA) through imprinting technique. Raman scattering, photoelectron spectroscopy and electron microscopy techniques were employed to study the properties of Mo2C nanoparticles. FA imprinting was carried out in the presence of pyrrole monomer over Mo2C modified glassy carbon electrode (GCE). The proposed sensor showed the detection behavior for wide range of FA concentrations from 0.01 µM to 120 µM with an excellent LOD value of 4 nM and good selectivity toward FA as compared to other co-existing species in real samples. The fabricated MIP-Mo2C/GCE sensors were able to be replicated with ∼1.9% RSD, and their reproduced sensor offered good repeatability (RSD; 1.6%) and stability.


Subject(s)
Folic Acid/blood , Molybdenum/chemistry , Nanoparticles/chemistry , Vitamin B Complex/blood , Biosensing Techniques/methods , Electrochemical Techniques/methods , Electrodes , Folic Acid/analysis , Humans , Limit of Detection , Molecular Imprinting , Polymerization , Pyrroles/chemistry , Vitamin B Complex/analysis
12.
Analyst ; 144(7): 2345-2352, 2019 Mar 25.
Article in English | MEDLINE | ID: mdl-30785148

ABSTRACT

Apart from being a vital catecholamine molecule responsible for the proper functioning of the central nervous system (CNS), hormonal and renal systems, dopamine (DA) has also been increasingly employed as a functional monomer in the fabrication of surface molecular imprinting polymers (MIPs) for valuable analytes. Herein, we demonstrate the effective imprinting of 6-thioguanine (6-TG), an anticancer drug, via mussel-inspired self-polymerization of dopamine conducted in a weakly alkaline solution over reduced graphene oxide (rGO). The polymerization of 6-TG resulted into a thin polydopamine (PDA) film of 8.4 nm thickness. Removal of 6-TG molecules from this imprinted PDA film created numerous cavities of 6-TG. The electrochemical investigation of MIP electrodes found an excellent electrocatalytic activity toward 6-TG with a significant decrease in the over-potential as compared to that of the bare glassy carbon electrode (GCE). This can be attributed to the graphene's distinct physical and chemical features such as subtle electronic characteristics, an attractive π-π interaction as well as the strong adsorptive capability of MIP films. This electrochemical sensor displayed a high selectivity owing to the specific imprinted cavities for adrenaline and worked well over a wide linear concentration range of adrenaline between 0.0015 and 50 µM with a detection limit (LOD) of 0.25 nM and good reproducibility and stability. Our system depicts excellent recoveries from 97.0% to 100.6% for two different samples of urine and thioguanine drugs. These results show the great potential of our system with multiple advantages, including convenient fabrication and optimization, high sensitivity and selectivity, high reproducibility and stability, and cost-effectiveness.


Subject(s)
Bivalvia , Graphite/chemistry , Indoles/chemistry , Molecular Imprinting/methods , Oxides/chemistry , Polymerization , Polymers/chemistry , Thioguanine/chemistry , Animals , Antineoplastic Agents/analysis , Antineoplastic Agents/chemistry , Biomimetics , Calibration , Electrochemistry , Electrodes , Indoles/chemical synthesis , Oxidation-Reduction , Polymers/chemical synthesis , Thioguanine/analysis
13.
Crit Rev Anal Chem ; 49(4): 324-335, 2019.
Article in English | MEDLINE | ID: mdl-30601038

ABSTRACT

Cancer has been responsible for high morbidity and mortality globally. The treatment of cancer is possible using different kinds of therapies using anticancer drugs if it is diagnosed at the right time. Nevertheless, their appropriate administration for maximum therapeutic effect and their elimination from the patient's body causing environmental problems are two big issues which could be successfully abated using molecular imprinted polymers (MIPs) owing to their unique features. In this review, we have compiled and discussed the works on the determination and controlled release of anticancer drugs based on MIPs. We also highlighted the current challenges and remedies, and the future direction of MIPs in this area.


Subject(s)
Antineoplastic Agents , Environmental Monitoring , Environmental Pollutants , Molecular Imprinting , Antineoplastic Agents/adverse effects , Antineoplastic Agents/analysis , Environmental Pollutants/adverse effects , Environmental Pollutants/analysis , Humans
14.
ACS Appl Mater Interfaces ; 9(28): 24179-24189, 2017 Jul 19.
Article in English | MEDLINE | ID: mdl-28654230

ABSTRACT

Doping with heteroatoms is a well-established method to tune the electronic properties and surface chemistry of graphene. Herein, we demonstrate the synthesis of a fluorine-doped reduced graphene oxide (FrGO) at low temperatures that offers multiple opportunities in applied fields. The as-synthesized FrGO product shows a better electrical conductivity of 750 S m-1 than that of undoped rGO with an electrical conductivity of 195 S m-1. To demonstrate the multifunctional applications of the as-synthesized FrGO, it was examined for electromagnetic interference shielding and electrochemical sensing of histamine as an important food biomarker. A laminate of FrGO delivered an EMI shielding effectiveness value of 22 dB in Ku band as compared with 11.2 dB for an rGO laminate with similar thickness. On the other hand, an FrGO modified sensor offered an excellent sensitivity (∼7 nM), wide detection range, and good selectivity in the presence of similar biomarkers. This performance originates from the better catalytic ability of FrGO as compared with rGO, where fluorine atoms play the role of catalytic active sites owing to their high electronegativity. The fluorination reaction also helps to improve the reduction degree of the chemically synthesized graphene, consequently enhancing the electrical conductivity, which is a prime requirement for increasing the electromagnetic and electrochemical properties of graphene.

15.
Biosens Bioelectron ; 94: 714-718, 2017 Aug 15.
Article in English | MEDLINE | ID: mdl-28395254

ABSTRACT

This work demonstrates the facile and efficient preparation protocol of ß-Cyclodextrin-reduced graphene oxide modified glassy carbon electrode (ß-CD/RGO/GCE) sensor for an impressive chiral selectivity analysis for phenylalanine enantiomers. In this work, the immobilization of ß-CD over graphene sheets allows the excellent enantiomer recognition due to the large surface area and high conductivity of graphene sheets and extraordinary supramolecular (host-guest interaction) property of ß-CD. The proposed sensor was well characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and electrochemical impedance spectroscopy (EIS) techniques. The analytical studies demonstrated that the ß-CD/RGO/GCE exhibit superior chiral recognition toward L-phenylalanine as compared to D-phenylalanine. Under optimum conditions, the developed sensor displayed a good linear range from 0.4 to 40µM with the limit of detection (LOD) values of 0.10µM and 0.15µM for l- and D-phenylalanine, respectively. Furthermore, the proposed sensor exhibits good stability and regeneration capacity. Thus, the as-synthesized material can be exploited for electrochemical enantiomer recognition successfully.


Subject(s)
Biosensing Techniques/methods , Electrochemical Techniques/methods , Phenylalanine/isolation & purification , beta-Cyclodextrins/chemistry , Carbon/chemistry , Dielectric Spectroscopy , Electrodes , Graphite/chemistry , Limit of Detection , Microscopy, Electron, Scanning , Oxides/chemistry , Phenylalanine/chemistry , Spectroscopy, Fourier Transform Infrared
16.
Biomater Sci ; 5(3): 388-402, 2017 Feb 28.
Article in English | MEDLINE | ID: mdl-28138673

ABSTRACT

Molecular imprinted polymerization is considered one of the most useful preparation strategies to obtain highly selective polymeric materials called molecular imprinted polymers (MIPs). It has attracted a tremendous amount of interest in the last decade. Consequently, MIPs have been employed in a variety of applications including chromatographic separation, sensors and biosensors fabrication, drug delivery, proteomic analysis and plastic antibody synthesis, etc. The hybridization of the excellent features of MIPs and nanomaterials has further fueled the intensity of research in this area. A good number of works have been reported on MIP-nanomaterial composites in last few years covering all types of applications. In this review, we discuss the basic fundamentals of MIPs, nanomaterials and their combined applications. As a proof of concept, we included selective works published from 2012 to 2016.


Subject(s)
Molecular Imprinting/methods , Nanostructures/chemistry , Nanotechnology/methods , Polymers/chemistry , Animals , Biosensing Techniques/methods , Chromatography/methods , Drug Delivery Systems/methods , Graphite/chemistry , Humans , Nanostructures/ultrastructure , Nanotubes, Carbon/chemistry , Nanotubes, Carbon/ultrastructure , Polymerization , Proteomics/methods , Solid Phase Extraction/methods
17.
Talanta ; 149: 30-42, 2016.
Article in English | MEDLINE | ID: mdl-26717811

ABSTRACT

Diabetes is a major health problem causing 4 million deaths each year and 171 million people suffering worldwide. Although there is no cure for diabetes, nevertheless, the blood glucose level of diabetic patients should be monitored tightly to avoid further complications. Thus, monitoring of glucose in blood has become an inevitable need leading to fabrication of accurate and sensitive advanced blood sugar detection devices for clinical diagnosis and personal care. It led to the development of enzymatic glucose sensing approach. Later on, various types of nanostructures have been utilized owing to their high surface area, great stability, and cost effectiveness for the fabrication of enzymatic as well as for nonenzymatic glucose sensing approach. This work reviews on both categories, however it is not intended to discuss all the research reports published regarding nanostructure based enzymatic and nonenzymatic approaches between mid-2010 and mid-2015. We, do, however, focused to describe the details of many substantial articles explaining the design of sensors, and utilities of the prepared sensors, so that readers might get the principles behind such devices and relevant detection strategies. This work also focuses on biocompatibility and toxicity of nanomaterials as well as provides a critical opinion and discussions about misconceptions in glucose sensors.


Subject(s)
Glucose/analysis , Nanostructures/chemistry , Animals , Biosensing Techniques , Electrochemical Techniques , Glucose Oxidase/chemistry , Humans , Metals/chemistry , Oxides/chemistry
18.
Drug Deliv ; 23(7): 2262-2271, 2016 Sep.
Article in English | MEDLINE | ID: mdl-25317753

ABSTRACT

This review is aimed to discuss the molecular imprinted polymer (MIP)-based drug delivery systems (DDS). Molecular imprinted polymers have proved to possess the potential and also as a suitable material in several areas over a long period of time. However, only recently it has been employed for pharmaceuticals and biomedical applications, particularly as drug delivery vehicles due to properties including selective recognition generated from imprinting the desired analyte, favorable in harsh experimental conditions, and feedback-controlled recognitive drug release. Hence, this review will discuss their synthesis, the reason they are selected as drug delivery vehicles and for their applications in several drug administration routes (i.e. transdermal, ocular and gastrointestinal or stimuli-reactive routes).


Subject(s)
Molecular Imprinting/methods , Polymers/chemistry , Animals , Delayed-Action Preparations/chemistry , Drug Administration Routes , Drug Delivery Systems/methods , Humans , Technology, Pharmaceutical/methods
19.
Electrophoresis ; 34(9-10): 1375-82, 2013 May.
Article in English | MEDLINE | ID: mdl-23423834

ABSTRACT

To extend the application of molecularly imprinted polymers, the dual-templates molecularly imprinted monolithic columns were developed in a capillary format. Two templates serotonin and histamine were simultaneously imprinted using two different functional monomers such as methacrylic acid (MAA) and methylenesuccinic acid (MSA) in a mixture of ethylene glycol dimethacrylate (EDMA) as a cross-linker and AIBN as polymerization initiator dissolved in DMF as porogen. The resulting molecular imprinted polymers (MIPs) were characterized based on their performance in the CEC separation of two imprinted templates. The optimization parameters such as pH, ACN composition, and concentration of the eluent were varied to achieve best resolution and efficiency for CEC separation of templates with each MIP column. It was found that the MIP monolith column fabricated using MSA offered better resolution and separation efficiency compared to column fabricated with MAA. This work utilized the dual-templates imprinting approach successfully and broadens the scope of multi-templates imprinting capabilities in capillary format in CEC application.


Subject(s)
Capillary Electrochromatography/methods , Histamine/isolation & purification , Molecular Imprinting/methods , Serotonin/isolation & purification , Cross-Linking Reagents/chemistry , Methacrylates/chemistry , Reproducibility of Results , Sensitivity and Specificity , Succinates/chemistry
20.
J Nanosci Nanotechnol ; 12(8): 6368-73, 2012 Aug.
Article in English | MEDLINE | ID: mdl-22962750

ABSTRACT

A facile, reliable, reproducible and ultra-high sensitive aqueous ammonia chemical sensor has been fabricated based on the utilization of La(0.7)Sr(0.3)MnO3 nanoparticles (LSMO NPs), as efficient electron mediators, and reported in this paper. The LSMO NPs were prepared by hydrothermal protocol followed by the annealing process and characterized in detail in terms of their mophological, structural and compositional properties. The I-V technique based aqueous ammonia sensor exhibits an ultra-high sensitivity of 494.68 +/- 0.01 microA cm(-2)mM(-1) and very low-detection limit of 0.2 microM with a response time less than 10 s. To the best of our knowledge, this is the first report in which LSMO is used as an efficient electron mediator for the fabrication of aqueous ammonia chemical sensor. Moreover, by comparing the literature, it is confirmed that the fabricated sensor exhibits highest sensitivity towards the detection of aqueous ammonia. This LSMO nanomaterial based research broadens the range of efficient electron mediators utilized for the fabrication of ultra-high sensitive chemical sensors.

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