ABSTRACT
The efficacy of multimodality conservative treatment for prostate and bladder cancer and cervical carcinoma was improved due to integration of such modem modalities as intra-arterial chemotherapy, local hyperthermia and hyperglycemia and combination of local and systemic radiomodifiers. Our methods use criteria of actual survival and are intended to raise it.
Subject(s)
Biomedical Research , Radiotherapy , Academies and Institutes , Animals , Female , Government Agencies , Humans , Low-Level Light Therapy , Male , Prostatic Neoplasms/radiotherapy , Radiation-Sensitizing Agents/therapeutic use , Radiotherapy/methods , Radiotherapy/trends , Thyroid Neoplasms/radiotherapy , Urinary Bladder Neoplasms/radiotherapy , Uterine Cervical Neoplasms/radiotherapyABSTRACT
A recent theoretical result of Kendal (1998) enabled us to develop a survival model which allows for proliferation of tumor clonogenic cells in the course of fractionated radiotherapy. We explored this model during an analysis of clinical data on survival of 982 patients with cancer of the cervix uteri. The model provided a good description of survival patterns in different groups of patients. The estimated cure probability did not correlate with the rates of cell proliferation between exposures to radiation. Also, our results showed that this parameter cannot be estimated from survival data. Some light has been thrown on the relationship of cell proliferations taking place between exposures, on the one hand, and end-results of treatment for cancer of the cervix uteri, on the other.
