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1.
PLoS One ; 17(9): e0273638, 2022.
Article in English | MEDLINE | ID: mdl-36156591

ABSTRACT

BACKGROUND: The COVID-19 pandemic has severely impacted healthcare delivery and patient outcomes globally. AIMS: We aimed to evaluate the influence of the COVID-19 pandemic on the temporal trends and outcomes of patients undergoing percutaneous coronary intervention (PCI) in Michigan. METHODS: We compared all patients undergoing PCI in the BMC2 Registry between March and December 2020 ("pandemic cohort") with those undergoing PCI between March and December 2019 ("pre-pandemic cohort"). A risk-adjusted analysis of in-hospital outcomes was performed between the pre-pandemic and pandemic cohort. A subgroup analysis was performed comparing COVID-19 positive vs. negative patients during the pandemic. RESULTS: There was a 15.2% reduction in overall PCI volume from the pre-pandemic (n = 25,737) to the pandemic cohort (n = 21,822), which was more pronounced for stable angina and non-ST-elevation acute coronary syndromes (ACS) presentations, and between February and May 2020. Patients in the two cohorts had similar clinical and procedural characteristics. Monthly mortality rates for primary PCI were generally higher in the pandemic period. There were no significant system delays in care between the cohorts. Risk-adjusted mortality was higher in the pandemic cohort (aOR 1.26, 95% CI 1.07-1.47, p = 0.005), a finding that was only partially explained by worse outcomes in COVID-19 patients and was more pronounced in subjects with ACS. During the pandemic, COVID-19 positive patients suffered higher risk-adjusted mortality (aOR 5.69, 95% CI 2.54-12.74, p<0.001) compared with COVID negative patients. CONCLUSIONS: During the COVID-19 pandemic, we observed a reduction in PCI volumes and higher risk-adjusted mortality. COVID-19 positive patients experienced significantly worse outcomes.


Subject(s)
Acute Coronary Syndrome , COVID-19 , Percutaneous Coronary Intervention , COVID-19/epidemiology , Humans , Michigan/epidemiology , Pandemics , Percutaneous Coronary Intervention/adverse effects , Registries , Treatment Outcome
2.
Cureus ; 12(9): e10498, 2020 Sep 16.
Article in English | MEDLINE | ID: mdl-33094042

ABSTRACT

Kounis syndrome (KS) is an acute coronary event secondary to an allergic reaction. It is provoked by environmental agents, food, and medications. KS is caused by the release of allergic mediators. We are reporting a case of a 39-year-old man who had a syncopal episode after he took cephalexin and ibuprofen for toothache. He developed chest pain and erythematous rash later. His electrocardiography did not show any ST-segment elevation changes and cardiac troponins were elevated. He was started on the acute coronary syndrome treatment protocol. Coronary angiography revealed no significant obstructive or culprit lesions. The patient was discharged home in stable condition. He is advised to adhere to lifestyle modification and outpatient follow-up with cardiology and allergy/immunology. KS is infrequently reported in the medical literature. Physicians should pay attention to any allergic reaction preceding the acute cardiac event and consider KS in the differential diagnosis.

3.
Catheter Cardiovasc Interv ; 95(3): E84-E95, 2020 02 15.
Article in English | MEDLINE | ID: mdl-31631511

ABSTRACT

BACKGROUND: The impact of end-stage renal disease (ESRD) on peripheral vascular intervention (PVI) outcome remains incompletely elucidated. OBJECTIVES: We sought to compare the outcome of PVI in dialysis patients with those with normal kidney function. METHODS: Using weighted data from the National Inpatient Sample database between 2002 and 2014, we identified all peripheral artery disease (PAD) patients aged ≥18 years that underwent PVI. Multivariate logistic regression analysis was performed to examine in-hospital outcomes. RESULTS: Of 1,186,192 patients who underwent PVI, 1,066,830 had normal kidney function (89.9%) and 119,362 had ESRD requiring dialysis (10.1%). Critical limb ischemia was more prevalent in dialysis patients (63.2 vs. 34.0%, p < .001). Compared with normal kidney function group, ESRD requiring dialysis was associated with higher in-hospital mortality (1.5 vs. 4.2%, adjusted OR: 2.13 [95% CI: 2.04-2.23]) and longer length of hospital stay (median 3 days, Interquartile range [IQR] (0-6) vs. 7 days, IQR (4-18); p < .001). Dialysis patients had higher incidence of major adverse cardiovascular events (composite of death, myocardial infarction, or stroke; 14.3 vs. 9.8%, p < .001) and net adverse cardiovascular events (composite of MACE, major bleeding, or vascular complications; 40.8 vs. 29.1%, p < .001). ESRD patients less frequently underwent open bypass (5.6 vs. 8.5%, p < .001) and more frequently had major amputation (10.3 vs. 3.0%, p < .001) compared with normal kidney function group. CONCLUSION: PAD patients on dialysis who underwent PVI have higher rates of mortality and adverse outcomes as compared to those with normal kidney function.


Subject(s)
Endovascular Procedures , Ischemia/therapy , Kidney Failure, Chronic/therapy , Kidney/physiopathology , Peripheral Arterial Disease/therapy , Renal Dialysis , Aged , Aged, 80 and over , Critical Illness , Databases, Factual , Endovascular Procedures/adverse effects , Endovascular Procedures/mortality , Female , Hospital Mortality , Humans , Inpatients , Ischemia/diagnosis , Ischemia/mortality , Ischemia/physiopathology , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/mortality , Kidney Failure, Chronic/physiopathology , Male , Middle Aged , Peripheral Arterial Disease/diagnosis , Peripheral Arterial Disease/mortality , Peripheral Arterial Disease/physiopathology , Renal Dialysis/adverse effects , Renal Dialysis/mortality , Retrospective Studies , Risk Assessment , Risk Factors , Time Factors , Treatment Outcome , United States/epidemiology
4.
Am J Cardiol ; 124(10): 1540-1548, 2019 11 15.
Article in English | MEDLINE | ID: mdl-31522770

ABSTRACT

The impact of atrial fibrillation (AF) on clinical outcomes among patients with peripheral artery disease (PAD) who undergo limb revascularization procedures is not well understood. We aim to compare in-hospital outcomes for patients with and without AF who underwent limb revascularization. We identified patients with PAD aged ≥18 years that underwent limb revascularization using endovascular or surgical approaches in the National Inpatient Sample between 2002 and 2014. Multivariate logistic regression analysis was performed to examine in-hospital outcomes. A total of 2,283,568 patients underwent limb revascularization during the study duration and 294,469 (12.9%) had AF. Patients with AF were older (mean age 76.1 ± 10.0 years), more likely to be women and white, compared with non-AF group. Among patients who had surgical revascularization, AF was associated with a higher rates of in-hospital mortality (6.4% vs 2.5%, adjusted odds ratio [aOR]: 1.09 [95% confidence interval {CI}: 1.05 to 1.12]) and major amputation (5.2% vs 3.8%, aOR: 1.05 [95% CI: 1.02 to 1.08]), compared with non-AF group. Among patients who had endovascular intervention (EVI), AF was associated with a higher rates of in-hospital mortality (3.8% vs 1.6%, aOR: 1.29 [95% CI: 1.24 to 1.33]) and major amputation (5.2% vs 3.9%, aOR: 1.07 [95% CI: 1.04 to 1.10]), compared with non-AF group. Within study period, EVI utilization increased in patients with and without AF (Ptrend <0.001); whereas, surgical revascularization utilization decreased in patients with and without AF (Ptrend <0.001). In conclusion, among patients with PAD who undergo limb revascularization, AF appears to be associated with poor in-hospital outcomes.


Subject(s)
Atrial Fibrillation/complications , Endovascular Procedures/methods , Lower Extremity/blood supply , Peripheral Arterial Disease/surgery , Risk Assessment/methods , Aged , Atrial Fibrillation/epidemiology , Female , Hospital Mortality/trends , Humans , Incidence , Male , Peripheral Arterial Disease/complications , Peripheral Arterial Disease/epidemiology , Retrospective Studies , Risk Factors , Survival Rate/trends , United States/epidemiology
5.
Heart Lung ; 48(1): 22-27, 2019 01.
Article in English | MEDLINE | ID: mdl-30172414

ABSTRACT

INTRODUCTION: Digitalis has been used for over 200 years to treat patients with heart failure, and evidence supports its use to improve clinical symptoms and quality of life, but not survival. The objective of this retrospective study was to evaluate the effects of digitalis on readmission and mortality in patients with heart failure with reduced ejection fraction (HFrEF) who were receiving current guideline recommended medical therapy. METHODS: We reviewed medical record data from a retrospective cohort study of 1047 patients admitted to the hospital from 2005 to 2014 with decompensated HFrEF. 244 received digitalis, at some point during patient trajectory, and 803 never received digitalis. The primary outcomes of interest were the length of stay in hospital, readmission rates after discharge at 1, 6, 12, and 24 months and the overall mortality rate, at the same time points. RESULTS: We studied the effects of digitalis after adjusting for age, sex, race, potentially confounding comorbidities, and prescription medications. Digitalis treatment is associated with decreases in EF in patients with HFrEF (OR = -2.83, P < 0.001) and was associated with an increased readmission rate for any reason after discharge from the hospital at 6, 12, and 24 months, 53%, 34%, and 35%, respectively. No statistically significant difference was found between patients who received digitalis and those who did not (referent group) for the length of hospital stay and overall mortality rate. CONCLUSION: Digitalis use is associated with increased re-admission rates for any reason following discharge from the hospital at 6, 12, and 24 months.


Subject(s)
Digoxin/pharmacokinetics , Heart Failure/drug therapy , Patient Readmission/trends , Quality of Life , Stroke Volume/physiology , Aged , Cardiotonic Agents/pharmacokinetics , Female , Heart Failure/metabolism , Heart Failure/mortality , Humans , Patient Discharge/trends , Retrospective Studies , Survival Rate/trends , United States/epidemiology
6.
Cardiovasc Revasc Med ; 20(8): 649-653, 2019 08.
Article in English | MEDLINE | ID: mdl-30401590

ABSTRACT

BACKGROUND: Race-related differences in clinical features, presentation, treatment and outcomes of patients with various cardiovascular diseases have been reported in previous studies. However, the long-term outcomes in black versus white patients with popliteal and/or infra-popliteal peripheral arterial disease (PAD) undergoing percutaneous peripheral vascular interventions (PVI) are not well known. METHODS AND RESULTS: We retrospectively evaluated long-term outcomes in 696 patients (263 blacks and 433 whites) who underwent PVI for popliteal and/or infra-popliteal PAD at our institution between 2007 and 2012. When compared to white patients, black patients were younger (70 ±â€¯11 vs. 72 ±â€¯11; P = 0.002) and had more comorbidities: higher creatinine (2.04 ±â€¯2.08 vs. 1.33 ±â€¯1.16; P < 0.0001) with more ESRD (19% vs. 6%; P < 0.0001) and more diabetes (64% vs. 55%; P = 0.004). At mean follow-up of 36 ±â€¯20 months, there was no statistically significant difference between black and white patients either in all-cause mortality (29% vs. 32%; P = 0.38) or in major amputation (4.4% vs. 4.2%; P = 0.88), respectively. In a multi-variate Cox proportional hazard model, repeat ipsilateral percutaneous revascularization or bypass were lower in black patients (HR = 0.64 [95% CI 0.46-0.89]; P = 0.007) and major adverse vascular events (MAVE) were lower in black patients as well (HR = 0.7 [95% CI 0.56-0.89]; P = 0.003). CONCLUSION: Black patients undergoing popliteal or infra-popliteal PVI had similar mortality and major amputation, but lower repeat revascularization and MAVE compared to white patients. These data support the use of PVI in minorities despite higher baseline comorbidities and call for more research to understand the mechanisms underlying the high mortality irrespective of race.


Subject(s)
Angioplasty, Balloon , Black or African American , Peripheral Arterial Disease/therapy , Popliteal Artery , White People , Aged , Aged, 80 and over , Amputation, Surgical , Angioplasty, Balloon/adverse effects , Angioplasty, Balloon/mortality , Comorbidity , Female , Humans , Limb Salvage , Male , Middle Aged , Peripheral Arterial Disease/diagnosis , Peripheral Arterial Disease/ethnology , Peripheral Arterial Disease/mortality , Popliteal Artery/diagnostic imaging , Retreatment , Retrospective Studies , Risk Assessment , Risk Factors , Time Factors , Treatment Outcome , United States/epidemiology
7.
Am J Med Sci ; 357(4): 333-337, 2019 04.
Article in English | MEDLINE | ID: mdl-30545698

ABSTRACT

Coronary embolism (CE) is an uncommon and unique cause of acute myocardial infarction. In this report, we review 216 cases of CE including 2 new cases from our institution. The mean patient age was 52.5 years and 62% of the patients were males. Chest pain was the most common presenting symptom followed by dyspnea, and the most commonly affected vessel was the left anterior descending artery. Leading etiologies of the embolus were atrial fibrillation, septic emboli, and iatrogenic causes. Treatment approaches varied with thrombus aspiration being used in 30% of cases. In-hospital mortality rate was 36% and 13% of the cases were complicated by cerebrovascular accident. CE is a unique pathology that leads to acute myocardial infarction. It portends a high mortality rate and requires a high level of suspicion as symptoms may be misleading. Further research is needed in order to improve recognition and management and to lower associated mortality.


Subject(s)
Coronary Artery Disease , Embolism , Adult , Coronary Artery Disease/diagnosis , Coronary Artery Disease/etiology , Coronary Artery Disease/mortality , Coronary Artery Disease/therapy , Embolism/diagnosis , Embolism/etiology , Embolism/mortality , Embolism/therapy , Humans , Male , Myocardial Infarction/etiology , Myocardial Infarction/pathology
8.
J Invasive Cardiol ; 30(11): E124-E125, 2018 11.
Article in English | MEDLINE | ID: mdl-30373955

ABSTRACT

Deep vein thrombosis due to superficial femoral artery aneurysm is an extremely rare condition that develops due to aneurysm direct compression of a segment of the venous system. We present a 57-year-old female patient who had recently undergone a left superficial femoral artery (SFA) intervention at an outside institution due to significant peripheral artery disease. Imaging revealed a 3.2 cm SFA aneurysm with secondary mass effect on the left mid superficial femoral vein. She underwent successful exclusion of the aneurysm with a 6.0 x 10 cm Viabahn covered stent.


Subject(s)
Aneurysm/surgery , Coated Materials, Biocompatible , Femoral Artery/surgery , Femoral Vein , Stents , Venous Thrombosis/surgery , Aneurysm/complications , Aneurysm/diagnosis , Computed Tomography Angiography , Female , Femoral Artery/diagnostic imaging , Humans , Middle Aged , Prosthesis Design , Venous Thrombosis/diagnosis , Venous Thrombosis/etiology
9.
Am Heart J ; 204: 1-8, 2018 10.
Article in English | MEDLINE | ID: mdl-30077047

ABSTRACT

BACKGROUND: The radial artery (RA) is routinely used for both hemodynamic monitoring and for cardiac catheterization. Although cannulation of the RA is usually undertaken through manual palpation, ultrasound (US)-guided access has been advocated as a mean to increase cannulation success rates and to lower RA complications; however, the published data are mixed. We sought to evaluate the impact of US-guided RA access compared with palpation alone on first-pass success to access RA. METHODS AND RESULTS: Meta-analysis of 12 randomized controlled trials comparing US-guided with palpation-guided radial access in 2,432 adult participants was done. Hemodynamic monitoring was the most common reason for RA catheterization. Only 2 randomized controlled trials evaluated patients undergoing cardiac catheterization. Ultrasound-guided radial access was associated with increased first-attempt success rate (risk ratio [RR] 1.35, 95% CI 1.16-1.57]) and decreased failure rate (RR 0.52, 95% CI 0.32-0.87). There were no significant differences in the risk of hematoma (RR 0.43, 95% CI 0.27-1.06), the mean time to first successful attempt (mean difference 25.13 seconds, 95% CI -1.06 to 51.34) or to any successful attempt (mean difference -4.74 seconds; 95% CI -22.67 to 13.18) between both groups. CONCLUSIONS: Ultrasound-guided technique for RA access has higher first-attempt success and lower failure rate compared with palpation alone, with no significant differences in access site hematoma or time to a successful attempt. These findings support the routine use of US guidance for RA access.


Subject(s)
Catheterization, Peripheral/methods , Radial Artery/diagnostic imaging , Adult , Cardiac Catheterization/adverse effects , Cardiac Catheterization/methods , Catheterization, Peripheral/adverse effects , Hematoma/etiology , Hemodynamics , Humans , Monitoring, Physiologic/adverse effects , Monitoring, Physiologic/methods , Palpation , Randomized Controlled Trials as Topic , Ultrasonography
10.
Cardiovasc Revasc Med ; 19(8S): 60-64, 2018 12.
Article in English | MEDLINE | ID: mdl-29793898

ABSTRACT

Percutaneous coronary interventions involving coronary bifurcation lesions are more complex and associated with adverse outcomes (both angiographic and clinical) compared to non-bifurcation lesions. Tryton, a dedicated bifurcation stent, has been introduced with the aim to simplify treatment of bifurcation lesions. Tryton stent in combination with conventional drug eluting stent is safe and associated with reduced stenosis and bail-out stenting of side branch compared to provisional stenting involving a large side. However, little is known regarding safety and efficacy of Tryton stent in left main (LM) bifurcation lesion. We describe two cases of unprotected LM bifurcation stenting using Tryton stent in combination with drug eluting stent.


Subject(s)
Coronary Artery Disease/surgery , Coronary Vessels/surgery , Drug-Eluting Stents , Percutaneous Coronary Intervention/methods , Aged , Coronary Angiography , Coronary Artery Disease/diagnosis , Coronary Vessels/diagnostic imaging , Humans , Male , Prosthesis Design , Ultrasonography, Interventional
11.
J Invasive Cardiol ; 29(12): E201, 2017 Dec.
Article in English | MEDLINE | ID: mdl-29207371

ABSTRACT

Inferior vena cava filters are indicated in patients with venous thromboembolic disease in whom anticoagulation is a contraindication. This case highlights the importance of inferior vena cava filter placement in patients with extensive proximal deep vein thromboses in order to prevent massive pulmonary emboli, possibly associated with sudden cardiac death.


Subject(s)
Lower Extremity/blood supply , Prosthesis Implantation/methods , Pulmonary Embolism , Vena Cava Filters , Venous Thrombosis , Aged , Computed Tomography Angiography/methods , Humans , Male , Pulmonary Embolism/diagnosis , Pulmonary Embolism/physiopathology , Pulmonary Embolism/prevention & control , Thrombolytic Therapy/methods , Treatment Outcome , Ultrasonography, Doppler, Duplex/methods , Ultrasonography, Interventional/methods , Venous Thrombosis/complications , Venous Thrombosis/diagnosis , Venous Thrombosis/physiopathology , Venous Thrombosis/surgery
12.
Vasc Med ; 22(6): 498-504, 2017 12.
Article in English | MEDLINE | ID: mdl-28980511

ABSTRACT

Black patients have a higher prevalence of peripheral artery disease (PAD) than white patients, and also tend to have a greater extent and severity of disease, and poorer outcomes. The association of race with quality of health (QOH) after peripheral vascular intervention (PVI), however, is less well-known. In our study, we hypothesized that after PVI, black patients experience worse QOH than white patients. We retrospectively assessed racial differences in health status using responses to the Peripheral Arterial Questionnaire (PAQ) at baseline (pre-PVI) and up to 6 months following PVI among 387 patients. We used the PAQ summary score (which includes physical limitation, symptoms, social function and quality of life) as a measure of QOH. We compared QOH scores at baseline and at follow-up after PVI between black ( n=132, 34.1%) and white ( n=255, 65.9%) patients. We then computed the change in score from baseline to follow-up for each patient (the delta) and compared the median delta between the two groups. Multivariable regression was used to model the delta QOH after controlling for factors associated with race or with the delta QOH. There was no significant difference in mean QOH by race either at baseline ( p=0.09) or at follow-up ( p=0.45). There was no significant difference in the unadjusted median delta by race (white 25.3 vs black 21.5, p=0.28) and QOH scores improved significantly at follow-up in both groups, albeit the improvement was marginally lower in black compared with white patients after adjustment for baseline confounders ( b = -6.6, p=0.05, 95% CI -13.2, -0.11).


Subject(s)
Black or African American/psychology , Health Status Disparities , Peripheral Vascular Diseases/therapy , Quality of Life , White People/psychology , Aged , Aged, 80 and over , Chi-Square Distribution , Female , Humans , Male , Michigan/epidemiology , Middle Aged , Multivariate Analysis , Peripheral Vascular Diseases/diagnosis , Peripheral Vascular Diseases/ethnology , Peripheral Vascular Diseases/psychology , Prevalence , Registries , Retrospective Studies , Risk Factors , Severity of Illness Index , Surveys and Questionnaires , Time Factors , Treatment Outcome
13.
J Invasive Cardiol ; 28(11): 430-439, 2016 Nov.
Article in English | MEDLINE | ID: mdl-27743508

ABSTRACT

OBJECTIVES: CENTRAL was a prospective, multicenter, 100 patient study designed to evaluate the ability of a recanalization catheter system to cross chronic total occlusions (CTOs) of the superficial femoral artery while staying within the central vessel lumen. METHODS: The primary endpoint was the successful crossing of a CTO (≥90% of the length) with the recanalization catheter in the central lumen of the superficial femoral artery in at least one-half of the studied patient population, confirmed by intravascular ultrasound. Secondary endpoints included standardized anatomic damage assessment (the TAPE method) and an assessment of the relationship between the percent of CTO crossing and TAPE scores to the rate of target-lesion revascularization (TLR) at 30 days and 6 months. RESULTS: The mean age of the occlusions was 16.6 ± 22.28 months (range, 1-120 months), the average occlusion length reported by the sites was 132.1 ± 87.69 mm (range, 4-300 mm), and a majority of lesions were moderately (42.0%) or severely (32.0%) calcified. In 43/85 (50.6%) of the evaluable intravascular ultrasound images, the recanalization catheter successfully navigated the central lumen of the CTO (ie, ≥90% luminal crossing) with >50% luminal crossing in 64/85 (75.3%) of cases. The 6-month TLR rate was significantly lower in patients where the CTO was crossed ≥90% in the central vessel lumen (4.7%) compared with crossings <90% (20.6%; P=.04). The 6-month TLR rate was 3.5% in patients with a favorable TAPE score of 0-4 and 36.8% with an unfavorable TAPE score of 5-8 (P<.001). CONCLUSION: Use of a recanalization catheter in complex superficial femoral artery CTO crossings achieved intraluminal crossings in >50% of cases and decreased anatomic damage, which appeared to offer a significant advantage in 6-month TLR rates.


Subject(s)
Arterial Occlusive Diseases , Catheterization, Peripheral , Femoral Artery , Ischemia , Lower Extremity/blood supply , Ultrasonography, Interventional/methods , Aged , Arterial Occlusive Diseases/diagnosis , Arterial Occlusive Diseases/etiology , Arterial Occlusive Diseases/surgery , Catheterization, Peripheral/instrumentation , Catheterization, Peripheral/methods , Female , Femoral Artery/diagnostic imaging , Femoral Artery/pathology , Femoral Artery/surgery , Humans , Ischemia/diagnosis , Ischemia/etiology , Ischemia/surgery , Male , Middle Aged , Outcome and Process Assessment, Health Care , Peripheral Vascular Diseases/complications , Severity of Illness Index , Vascular Calcification
15.
Subst Abus ; 34(1): 75-7, 2013.
Article in English | MEDLINE | ID: mdl-23327508

ABSTRACT

Two million Americans use cocaine on a regular basis. Sixty-nine percent of cocaine in the United States is adulterated with levamisole, a veterinary antihelminthic drug. In 2008, the first cases of levamisole-induced agranulocytosis and vasculopathy associated with adulterated cocaine were reported in the southwestern United States. Since then, reports of levamisole-associated toxicity have become increasingly common. The authors present the case of a 47-year-old woman from Michigan with purpuric lesions likely secondary to levamisole-induced leukocytoclastic vasculitis.


Subject(s)
Cocaine-Related Disorders/complications , Drug Contamination , Levamisole/adverse effects , Vasculitis, Leukocytoclastic, Cutaneous/chemically induced , Vasculitis, Leukocytoclastic, Cutaneous/complications , Female , Humans , Middle Aged
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