[Significance of the clinical characteristics of manic, manic- paranoid and manic-hebephrenic conditions for differentiated psychopharmacotherapy]. / Znachenie klinicheskikh osobennostei maniaka'lnykh, maniaka'lno-bredovykh i maniaka'lno-gebefrennykh sostoianii dlia differentsirovannoi psikhofarmakoterapii.

In order to improve the treatment of 200 patients with endogenous psychoses, a total of 412 manic, manic paranoid and manic-hebephrenic exacerbations were studied as well as 1130 psychopharmacotherapeutic interventions. Two-factor dispersion analysis has revealed a substantial impact of such major clinical factors as the nature of treatment, nosology and course type, syndrome variant, and their interrelations on the treatment efficiency. The sum of the factors explained about 25% of variance of the therapy efficiency rating. The data provided a basis for a system of differentiated indications to use various treatments and the tables of their comparative efficiency developed which can serve as a practical guide for the practitioner in his choice of an adequate therapy.

[Regression analysis of clinical data for purposes of predicting the efficacy of psychopharmacotherapy of episodes of schizophrenia]. / Regressionnyi analiz klinicheskikh dannykh v tseliakh prognoza éffektivnosti psikhofarmakoterapii pristupov shizofrenii.

Validity of a multidimensional statistics procedure for the prediction of the psychotropic drugs efficacy (PDE) was tested in a study on 60 schizophrenics showing the signs of an acute condition before treatment. Pretreatment ratings of 78 psychopathological symptoms underwent a computer analysis. A multiple stepwise regression equation was obtained which predicted PDE using ratings of 15 symptoms. A high correlation between the predicted and actual PDE was shown at cross-validation (r = +0.87), as well as a higher proportion of the PDE variance explained by the "regression" predictor rather than traditional "syndromal" one or the former's combination with the diagnosed type of the course (42%, 57.4% and 71.9%, respectively). Some methodological problems (homogeneity of patients and treatment conditions, the adequacy of the mathematical model applied) are discussed.

[Symptomatology of circular depression and prediction of the efficacy of treatment with tricyclic antidepressants]. / Simptomatika tsirkuliarnoi depressii i predskazanie éffektivnosti lecheniia tritsiklicheskimi antidepressantami.

The problem of efficacy prediction for psychopharmacotherapy of depressions is of considerable interest and urgency in view of frequently occurring resistance to antidepressants. The purpose of the present study was to study the feasibility of predicting the effectiveness of depression therapy in manic-depressive psychosis (MDP), based on the cross-sectional analysis of the patient's history (the clinical picture of the patient's condition prior to therapy) with the help of multivariate statistics. Eighty-two patients suffering from MDP with a variety of depressive states were examined. In addition to traditional descriptions, the clinical findings were documented by employing a system of standard evaluation scales. The data obtained were processed using the technique of multiple stepwise discriminant analysis. The latter resulted in the derivation of a mathematical prognostic formula allowing the prediction of tricyclic antidepressants efficacy.

[Effectiveness of treating early-onset malignant schizophrenia with psychotropic drugs and their combinations]. / Effektivnost' lecheniia rano nachavsheisia zlokachestvennoi shizofrenii razlichnymi psikhotropnymi sredstvami i ikh sochetaniiami.

The effectiveness of 1211 treatment courses given to 96 patients with "nuclear" schizophrenia was estimated by statistical methods with consideration of the therapy form (individual psychotropic drugs or their combinations) and the clinical variants of the disease. A number of statistically significant effects produced by these two factors and their interaction was revealed. The direction of the effects points to a relative advantage of the combined pharmacotherapy that envisages simultaneous use of drugs with different spectrum of action. In different variants of the disease, the efficacy of each of the 10 forms of the therapy was different: rather peculiar in this respect was the catatono-hebephrenic variant.

[Effect of moditen-depot therapy on the duration and quality of remissions in schizophrenia patients]. / Vliianie terapii moditenom-depo na dlitel'nost' i kachestvo remissii u bol'nykh schizofreniei.

The authors studied the effectiveness of out-patient treatment by Moditen-Deppt of 128 schizophrenic patients. A comparison of the previous remissions appearing during usual pharmacotherapy and remissions seen during Moditen-Depot treatment depicted statistically significant differences, indicating a distinct prevention of exacerbations due to this preparation, an increase in the duration and improved quality of remissions. Such improved remissions were expressed in lesser severity, in a decrease of psychopathological disturbances, changes qualified as a "mollification of a defect" and an improvement of some socio-clinical indices.

[Effect of lithium on the course of endogenous psychoses (several clinico-statistical relationships)]. / Vliianie litiia na techenie éndogennykh psikhozov (nekotorye kliniko-statisticheskie zavisimosti).

In 75 patients with a phasic development of endogenous psychoses the course of the disease before lithium treatment was characterized by statistically valid and successively increasing from attack to attack phenomena such as lengthening of attacks (phases) with a stable duration of the remissions and more frequent double phases. All of these phenomena were regarded by the authors as an unfavourable medicative pathomorphosis. The influence of lithium was expressed in the following symptoms: 1) prevention of hospitalization (56% of the cases); 2) significant shortening of the attacks (phases) and in some of the cases (19%)--their arrest; 3) transition from psychotic syndromes to cyclothymic; 4) a significant drop of double phases and a corresponding rise in the number of "pure" subdepressive states.