[Treatment of mild and moderate hypertension with enalapril (multicenter study of enap and enap N in Ukraine)]. / Lechenie miagkoi i umerennoi arterial'noi gipertonii énalaprilom (mnogotsentrovoe issledovanie énapa i énapa-N na Ukraine).

AIM: Assessment of efficiency and safety of enalapril (enap) and its combination with hydrochlorotiaside (enap-N). MATERIALS AND METHODS: 127 patients with mild and moderate blood hypertension entered an open non-comparative multicenter trial. 60 of them received enap (group 1), 67--enap N (group 2). Group 1 patients were given enap for 2 weeks in a dose 10 mg/day. If this dose was not adequate to normalize blood pressure, it was raised to 20-40 mg/day. Patients of group 2 received enap-N one tablet a day for 3 weeks. If the pressure persisted higher than 140/90 mm Hg, the treatment was continued for 3 weeks more in a dose of 2 tablets a day. RESULTS: Blood pressure lowered under 140/90 mm Hg in 40 patients of group 1 (66.7%). Systolic pressure dropped by 10 mm Hg minimum and diastolic by 5 mm minimum in 18 group 1 patients (30%). Enap-N reduced blood pressure under 140-90 mm Hg in 44 of 67 patients (65.7%). Systolic and diastolic pressure dropped, respectively, in 23(34.3%) patients. CONCLUSION: Enap and enap-N tablets were found highly effective and well tolerated. Side effects were caused by lowering of blood pressure.

[Practical games as one of the forms for optimizing the academic process in physician postgraduate training]. / Delovye igry kak odna iz form optimizatsii uchebnogo protsessa v poslediplomnoi podgotovke vrachei.

Described in the article is one of the forms of optimization of the instructional process in the postgraduation physician training--"business-like games". Highly skilled, competent position of the teacher who conducts a business-like game secures an active participation in learning of students, helps in opening the mind, broadening the outlook on the problem under consideration, gives much incentive to further independent work on the discussed issues.

[Effectiveness of nitrosorbide, corinfar and obsidan in preventing ischemia caused by the dipyridamole test]. / Effektivnost' nitrosorbida, korinfara i obzidana v preduprezhdenii ishemii, vyzvannoi dipiridamolovoi proboi.

The efficacy of nitrosorbide, corinfar and obsidan in preventing myocardial ischemia, induced by exercise or intravenous dipyridamole, was evaluated in 20 coronary patients. Nitrosorbide was found to be the most effective, and obsidan, the least effective, drug in preventing the steal syndrome. It is suggested that the efficiency of anti-anginal drugs is based on their effect on coronary flow control as well as hemodynamic determinants of myocardial oxygen requirements. The dipyridamole test can be used for the assessment of the effects of antianginal agents.

[Functional status of the myocardium of ischemic heart disease patients during long-term treatment with beta blockers]. / Funktsional'noe sostoianie miokarda u bol'nykh ishemicheskoi bolezn'iu serdtsa pri dlitel'nom lechenii beta-adrenoblokatorami.

Propranolol treatment for 6, 12 and 24 months was associated with a pronounced antianginal effect, both subjective and objective, in coronary patients, while the side effects rate was relatively small (3.3-7.3%). As the duration of treatment increases, the negative inotropic effect becomes less marked. Long-term propranolol treatment of coronary patients does not provoke any clinical signs of circulatory insufficiency. The treatment has the best effect in those coronary patients whose "double product" increases by more than 1.0 per 1 W of a standard 50 W load. The drug maximum antianginal effect is retained when this index drops below 1.0 in the course of two-week and six-month treatment.

[Diagnostic and treatment characteristics of ischemic heart disease patients with asynergies]. / Nekotorye osobennosti diagnostiki i lecheniia bol'nykh ishemicheskoi bolezn'iu serdtsa s asinergiiami.

A total of 64 patients with coronary heart disease were examined using contrast coronaro-ventriculography, veloergometry and estimation of the lactic acid level in the coronary sinus blood. Fifty-seven patients were referred to obsidan therapy by the "blind" method. Two groups of patients with asynergies of ischemic and cicatricial genesis were singled out. The sensitivity of the ST segment depression and sigma R increment as objective signs of ischemia significantly reduced in the presence of postinfarction cardiosclerosis. Obsidan monotherapy caused a rise of load power and volume of work performed in the patients with asynergies of ischemic origin: an antianginal effect of the drug in such cases was comparable to that in the patients without disturbed myocardial regional cantractility.

[Mechanisms of the anti-anginal effect of obzidan]. / O mekhanizmakh antianginal'nogo éffekta obzidana.

Using the blind method, a group of 91 coronary heart disease patients were studied. A two-week course of obsidan therapy proved to be most effective in patients with two impaired vessels and also in patients with a simultaneous decrease in the heart rate and in the systolic blood pressure during the threshold exercise. A parallel increase in the stroke index during exercise and a decrease in the myocardial contractile function at rest (by echocardiographic findings) suggest that the decrease in the systolic arterial pressure is associated with a negative inotropic effect of the drug. A decrease in the heart rate and myocardial contractility was observed only in patients with initial tachycardia and the intact functional state of the cardiac muscle. The best antianginal response occurs when these effects are combined.