ABSTRACT
(1) An enzyme preparation, Vasolastine, administered intramuscularly, to a group of elderly subjects (mean age 81.7) reduced fasting plasma cholesterol and triglyceride levels by amounts which were proportional to their initial concentration. (2) Triglyceride levels 3 h after a fat-rich meal were also directly dependent on the initial fasting level. This relationship is lowered significantly after 25 days of Vasolastine treatment. (3) It is suggested that these observations, taken in conjunction with the results of in vitro studies, confirm that Vasolastine acts synergistically with endogenous lipoprotein lipase.
Subject(s)
Aging/drug effects , Enzyme Therapy , Lipase , Lipids/blood , Lipoxygenase , Aged , Cholesterol/blood , Dietary Fats/pharmacology , Fasting , Female , Humans , Lipoprotein Lipase/blood , Middle Aged , Triglycerides/bloodABSTRACT
Skinfold thickness measurements on 626 normal subjects of both sexes between the ages of 5 months and 73 years demonstrated a tri-phasic relationship between loss of skin thickness and age. Measurements for infants of either sex were indistinguishable and high, falling rapidly to levels which only changed slightly over the period 20-60 years. Thereafter, massive loss of skin-thickness occurred in both sexes. Throughout the major portion of adult life the values obtained for females were significantly lower than those for males. It is suggested that the three phases may be associated with progressive dehydration, failure to synthesize collagen and frank degradation of the collagen of the dermis.
