Comparison of selected prooxidant-antioxidant balance and bone metabolism indicators and BDNF levels between older women with different levels of physical activity.

BACKGROUND: Given a lack of studies precisely indicating how many steps elderly people should take daily for their antioxidant defence, bone metabolism, and cognitive abilities to improve, our study set out to compare the selected antioxidant, prooxidant, bone turnover, and BDNF indicators between elderly women differing in physical activity (PA) measured by the daily number of steps. METHODS: The PA levels of 62 women aged 72.1 ± 5.4 years were assessed based on their daily number of steps and then were used to allocate the participants to three groups: group I (n = 18; <5,000 steps a day); group II (n = 22; from 5,000 to 9,999 steps a day); and group III (n = 22; ≥10,000 steps a day). Blood samples were collected from the participants in early morning hours and subjected to biochemical analysis for prooxidant-antioxidant balance indicators (SOD, CAT, GPx, GR, GSH, UA, MDA and TOS/TOC), bone metabolism indicators (Ca, 25-OH vitamin D, osteocalcin, CTX-I, and PTH), and BDNF levels. RESULTS: The groups were not statistically significantly different in the activity of SOD, CAT, GPx, and GR, but their concentrations of GSH (H = 22.10, p < 0.001) and UA (H = 12.20, p = 0.002) proved to be significantly associated with the groups' daily PA. The between-group differences in the concentrations of MDA and TOS/TOC were not significant, with both these indicators tending to take higher values in group I than in groups II and III. Significant differences between the groups were established for the concentrations of 25-OH vitamin D (H = 24.21, p < 0.001), osteocalcin (H = 7.88, p = 0.019), CTX-I (H = 12.91, p = 0.002), and BDNF (H = 14.47, p = 0.001), but not for Ca and PTH. CONCLUSIONS: Significantly higher concentrations of GSH, slightly lower oxidative stress indicators, significantly higher BDNF levels, and moderately better bone turnover indicators and resorption markers in the group taking more than 5,000 steps a day suggest that this level of PA can promote successful aging. More research is, however, needed to confirm this finding.

Assessment of Quality of Life and Pain Severity in Older Men with Osteoporosis: Cross-Sectional Study.

BACKGROUND: The quality of life in osteoporosis is studied for men rather than for women. Aim of the study was to determine how bone mass density (BMD) relates to life quality components and the severity of pain felt by men affected by osteoporosis. METHODS: Presented research is a cross-sectional study. The cohort of 62 men aged 65 to 85 years was divided into a group with osteoporosis (N = 27) and a group without osteoporosis (N = 35). The participants' quality of life was measured with the Qualeffo41 Questionnaire, BMD was quantified by densitometry, and pain intensity was assessed on the Visual Analogue Scale. RESULTS: We found that lower BMD was strongly correlated to participants' quality of life (r = -0.72), especially the quality of leisure and social activities (r = -0.66), general health perception (r = -0.59), and mobility (r = -0.57). Pain significantly affected general health perception in older men with osteoporosis. General health assessment and pain were highly correlated with each other (r = 0.888). CONCLUSION: BMD and the overall quality of life of the study participants were related to each other. The strongest relationship occurred between reduced BMD and leisure and social activities component. The pain significantly affected participants' general health perception. The results may be employed to create new prophylactic strategies to improve life quality in men with osteoporosis.

Device-Measured Physical Activity, Sedentary Behaviors, Built Environment, and Adiposity Gain in Older Women: A Seven-Year Prospective Study.

The search for determinants of adiposity gain in older women has become vitally important. This study aimed to (1) analyze the adiposity gain based on the participants' age and (2) determine the prospective associations of baseline intrapersonal, built environment, physical activity, and sedentary behavior variables with the adiposity gain in older women. This was a seven-year prospective study (baseline: 2009 to 2012; follow-up: 2016 to 2019) in older women (n = 178, baseline age = 62.8 ± 4.1 years). Baseline and follow-up adiposity (bioelectrical impedance) and baseline physical activity, sedentary behavior (accelerometers), and intrapersonal and built environment (Neighborhood Environment Walkability Scale questionnaire) variables were included. The body mass index (BMI) increment tended to be inversely associated with the women's age (p = 0.062). At follow-up, 48, 57, and 54% of the women had a relevant increase (d-Cohen > 0.2) in their BMI, percentage of body fat, and fat mass index, respectively. The women that spent ≥8 h/day being sedentary were 2.2 times (1.159 to 4.327 CI95%, p < 0.02) more likely to increase BMI (0.82 to 0.85 kg/m2) than non-sedentary women. No built environment variables were associated with seven-year adiposity gain (all ps > 0.05). A reduction in sedentary time should be promoted for adiposity gain prevention and health preservation in older women.

Does physical activity lower the risk for metabolic syndrome: a longitudinal study of physically active older women.

BACKGROUND: The associations between physical activity and metabolic syndrome (MetS) have been mainly found in cross-sectional studies. The aim of this longitudinal study was to examine the relationship between meeting step-based guidelines and changes in the risk of metabolic syndrome. METHODS: This study included data from older women (baseline age 62.9 ± 4.3 years) from a 7-year longitudinal study in Central Europe. At baseline and follow-up, physical activity was measured by an accelerometer, and the risk for MetS was assessed according to the NCEP-ATP III criteria. In 59 women, multivariate repeated measures ANOVA was used to compare differences in changes in the risk of MetS in groups based on meeting step-based guidelines (10,000 steps/day and 9000 steps/day for women aged <65 and ≥ 65 years, respectively). RESULTS: Over 7 years, steps/day increased from 10,944 ± 3560 to 11,652 ± 4865, and the risk of MetS decreased from 41 to 12% in our sample. Women who longitudinally met step-based guidelines had a significantly higher mean concentration of high-density cholesterol (HDL-C) (64.5 and 80.3 mg/dL at baseline and follow-up, respectively) and a lower concentration of triglycerides (TGs) (158.3 and 123.8 mg/dL at baseline and follow-up, respectively) at follow-up compared to baseline. Moreover, women who increased their daily steps over 7 years to the recommended steps/day value significantly decreased the concentration of TGs (158.3 mg/dL and 123.8 mg/dL at baseline and follow-up, respectively). CONCLUSIONS: Our study might suggest that the long-term meeting of step-based guidelines or an increase in daily steps/day to achieve the recommended value could be related to a lower risk of MetS, specifically in concentrations of HDL-C and TG. These findings may help in designing interventions aiming to decrease the risk of MetS in older women.

Prospective study on sedentary behaviour patterns and changes in body composition parameters in older women: A compositional and isotemporal substitution analysis.

BACKGROUND & AIMS: The aims of this study were to examine the prospective compositional associations between sedentary behaviour (SB) patterns and longitudinal changes in body composition parameters, and to use compositional isotemporal substitution modelling to analyse the longitudinal changes in body composition parameters associated with time reallocation from SB to physical activity (PA) in older women. METHODS: The study included women aged 60 years and older (n = 182) with valid data at baseline and at the subsequent 7-year follow-up. For both time points, the ActiGraph GT1M accelerometer was used for SB and PA assessments and multi-frequency bioimpedance analysis was used to assess the body composition parameters related to adiposity and muscle mass. Compositional regression models were used to analyse the associations between proportion of time spent in sedentary bouts of different duration and longitudinal changes in body composition parameters. A compositional isotemporal substitution model was created to estimate the differences in body composition parameters associated with one-to-one time reallocations between baseline SB and PA. RESULTS: A significant increase in fat mass index (ßilr1 = 0.61, 95% confidence interval [CI]: 0.18, 1.04) and visceral adipose tissue (ßilr1 = 6.01, 95% CI: 1.52, 10.5) was associated with a higher baseline proportion of time spent in long sedentary bouts (i.e. sedentary bout of ≥30 min). Reallocating 1 h/week and 3.5 h/week from the time spent in long sedentary bouts in favour of light PA was associated with a significant decrease in fat mass index by 0.78% (95% CI: 0.24, 1.32) and 3.13% (95% CI: 0.97, 5.29), respectively. No association was found for indicators of muscle mass. CONCLUSIONS: This study suggests that long-term adiposity status could be improved by increasing the proportion of time spent in light PA at the expense of time spent in prolonged SB. This finding may help in designing more effective and feasible interventions for the maintenance of healthy body composition in advanced age.

Osteoporosis in Polish Older Women: Risk Factors and Osteoporotic Fractures: A Cross-Sectional Study.

Background: Osteoporosis is a skeletal disease. It is still not known which of the risk factors have the greatest impact on osteoporosis development. The study aimed to determine how the selected osteoporosis risk factors contribute to the development of the disease and to assess the risk of osteoporotic fractures in older women. Methods: A cohort of 99 older females was divided into two groups (with and without osteoporosis). The risk of osteoporosis was determined using assessment forms and bone densitometry data subjected to logistic regression. The risk of osteoporotic fractures was assessed by the FRAX tool (FRAX, Center for Metabolic Bone Diseases, University of Sheffield, UK). Results: The logistic regression analysis showed that the highest risk of developing osteoporosis associated with lifestyle, mainly cigarette smoking (odds ratio: OR = 2.12), past gynecological operations (OR = 1.46), corticosteroid therapies (OR = 1.38). More than half of participants were at a medium risk of femoral neck fractures (over 90% in the osteoporotic group). Conclusion: Most of the Polish women living in care facilities are at medium risk of low-energy fractures. Smoking appeared to have the strongest effect on osteoporosis among analyzed risk factors. The results may contribute to the creation of more appropriate prevention strategies.

Influence of Nutritional Education on the Diet and Nutritional Behaviors of Elderly Women at the University of the Third Age.

BACKGROUND: The objective of this study was to evaluate the diet composition, body fat content, and physical activity (PA), considering blood lipid levels and insulin resistance markers, in elderly women who were well educated in nutrition and healthy lifestyle choices. METHODS: A total of 106 postmenopausal women took part in the study. The study group included 62 students from the University of the Third Age (U3A); the control group (CG) included 44 females from the Silesia region. We evaluated their daily macro and micronutrient intake, levels of PA, percent of body fat (PBF), and the visceral fatty area (VFA). We also evaluated the lipid profile, insulin and glucose levels, homeostatic model assessment of insulin resistance (HOMA-IR), and C-reactive protein (CRP) levels. RESULTS: Significant differences were observed in carbohydrate, protein, fiber, as well as vitamins and minerals consumption between the U3A group and the CG. There were no differences in the PBF and VFA between the groups. Furthermore, no differences were shown in the measured blood variables. The U3A group walked more than 11,000 steps a day and performed 46.15 min/day of PA with a moderate intensity of 3-6 metabolic equivalents of task (METs, min/week). CONCLUSIONS: Despite the fact that the U3A group were physically active females, well educated on healthy, balanced diets and had the motivation to learn about proper nutritional behaviors, they did not follow these recommendations in everyday life.

Are longitudinal reallocations of time between movement behaviours associated with adiposity among elderly women? A compositional isotemporal substitution analysis.

BACKGROUND: This study aimed to use compositional data analysis to: (1) investigate the prospective associations between changes in daily movement behaviours and adiposity among elderly women; and (2) to examine how the reallocation of time between movement behaviours was associated with longitudinal changes in adiposity. SUBJECTS/METHODS: This is a 7-year longitudinal study in Central European older women (n = 158, baseline age 63.9 ± 4.4 years). At baseline and follow-up, light-intensity physical activity (LIPA), moderate-to-vigorous physical activity (MVPA) and sedentary behaviour were measured by accelerometer and body adiposity (body mass index [BMI], body fat percentage [%BF]) was assessed from measured height and weight and bioelectrical impedance analyser. Compositional regression with robust estimators and compositional longitudinal isotemporal substitution analysis explored if, and how, changes in movement behaviours were associated with adiposity. RESULTS: Over 7 years, the prevalence of obesity in the sample increased by 10.1% and 14.6% according to BMI and %BF, respectively, and time spent in sedentary behaviour increased by 14%, while time spent in LIPA and MVPA decreased by 14% and 21%, respectively. The increase in sedentary behaviour at the expense of LIPA and MVPA during the 7-year period was associated with higher BMI and %BF at follow-up (both p < 0.01). The increase in LIPA or MVPA at the expense of sedentary behaviour was associated with reduced BMI and %BF at follow-up. In our sample, the largest change in BMI (0.75 kg/m2; 95% confidence interval [CI]: 0.37-1.13) and %BF (1.28 U; 95% CI: 0.48-2.09) was associated with longitudinal reallocation of 30 min from MVPA to sedentary behaviour. CONCLUSIONS: We found an association between longitudinal changes in daily movement behaviours and adiposity among elderly women in Central Europe. Our findings support public health programmes to increase or maintain time spent in higher-intensity physical activity among elderly women.

Reallocating Time from Sedentary Behavior to Light and Moderate-to-Vigorous Physical Activity: What Has a Stronger Association with Adiposity in Older Adult Women?

This study is the first to use compositional data analysis to investigate movement behaviors of elderly women and their relationships with fat mass percentage (FM%). The focus of the study is on the associations of time reallocations from sedentary behavior (SB) to light physical activity (LIPA) or moderate-to-vigorous physical activity (MVPA) with adiposity. Over 400 older adult women were recruited as part of the cross-sectionally conducted measurements of older adults aged 60+ in Central European countries. An accelerometer was used to assess daily movement behaviors. Body mass index (BMI) and fat mass percentage (FM%) were assessed as adiposity indicators using InBody 720 MFBIA. Using LS-regression, we found positive relationships of BMI and FM% with SB (relative to remaining movement behaviors) (p < 0.001 for both), while their relationship with MVPA (relative to remaining movement behaviors) were negative (p < 0.001 for both). The estimated BMI and FM% associated with a 30-min SB-to-MVPA reallocation were reduced by 1.5 kg/m² and 2.2 percentage points, respectively, whereas they were not reduced significantly with the reallocation of 30 min from SB to LIPA. The findings highlight that SB and MVPA, but not LIPA, are significantly associated with adiposity in elderly women. The reallocation of time from SB to MVPA could be advocated in weight loss interventions in older women.

Associations of visceral fat area and physical activity levels with the risk of metabolic syndrome in postmenopausal women.

This study was aimed at the evaluation of relationship between visceral fat area (VFA) and physical activity (PA) with the metabolic syndrome (MetS) risk in the physically active postmenopausal women. A total of 85 attendants of the University of the Third Age (U3A) aged 62.8 ± 5.9 years (median time since menopause 11.8 y), participated in this study. VFA was assessed by bioimpedance method using InBody 720 analyzer. PA was assessed using the ActiGraph GT1 M accelerometer. Fasting levels of serum lipids (TG, HDL), serum glucose, waist circumference (WC) and blood pressure were measured to diagnose MetS according to NCEP-ATP III criteria. In 73 out of 85 participants the VFA exceeded the upper normal level of 100 cm2, however, in almost a half of this group (n = 36) with elevated VFA (139.5 ± 26.1 cm2 on average), only 2 out of 5 criteria for MetS diagnosis were met. Participants were physically active, making on average 10,919 ± 3435 steps/day. The risk of MetS occurrence in women with VFA > 100 cm2 was twelve times higher (OR 12.33; CI 95% [1.5; 99.8]) than in the group with VFA < 100 cm2. The participants from the group with the highest PA level (≥12,500 steps/day) were at almost 4 times lower risk for MetS, than their less active counterparts (OR 3.84; CI 95% [1.27;11.64]). Increased level of VFA is a strong risk factor for the MetS in postmenopausal women, however high level of regular PA above the threshold of 12,500 steps/day may substantially reduce it.

Physical activity, body composition and general health status of physically active students of the University of the Third Age (U3A).

OBJECTIVE: To evaluate general health status of a group of older adults, physically active students of the University of the Third Age (U3A), based on results of biochemical analyses of blood, assessment of their physical activity (PA) level, body composition and cognitive function with respect to age and sex. METHODS: A total of 104 students (85 women and 19 men, aged 63.7±6.6 y) of the U3A's located in the Upper Silesia region of Poland volunteered to participate in this study. A habitual PA level and body composition were objectively assessed by using ActiGraph GT1M and InBody 720, respectively. Serum lipid profile and glucose metabolism markers were measured for assessment of cardiovascular disease risk factors. Moreover, subjects' cognitive functions were tested. RESULTS: Most of the study participants reached the daily step goal of 10,000 steps and thus fulfilled the ACSM recommendations for the quantity and quality of cardiorespiratory exercise. Highly negative correlations between the number of steps per day and body adiposity markers, serum insulin and HOMA-IR confirmed that vigorous physical activity at the recommended level was associated with better body composition and lower levels of risk markers of coronary heart disease and diabetes. Most of the U3A students were characterized by a favorable lipid profile, prevalence of normal blood pressure, low rates of HOMA-estimated insulin resistance and normal cognitive function. CONCLUSION: Adherence to ACSM recommendations is associated with beneficial changes in risk factors related to cardiovascular disease.

[Evaluation of accuracy of body mass index in diagnosing of obesity in relation to body fat percentage in female aged 55-84 years]. / Posouzení objektivity hodnocení výskytu obezity na základe bodymass indexu vzhledem k procentuálnímu zastoupení telesného tuku u zen ve veku 55-84 let.

BACKGROUND: Currently, body mass index (BMI) is frequently used for evaluation of obesity prevalence. This weight to height index does not reflect variability and changes in body composition components, and therefore, the BMI prevalence data may significantly differ from those based on the body fat percentage (%BFM). For the above reason, the primary aim of the study was to determine the prevalence of overweight and obesity according to %BFM and relate these data to BMI categories in women aged 55-84 years. METHODS AND RESULTS: 446 females with an average age of 65.8 ± 6.4 years participated in this study. Body composition was measured using InBody 720. Our results have shown high prevalence of overweight and obesity in the study sample. Number of obese subjects increased with increasing age. We found the highest prevalence of obesity in females over 80 years. Evaluation of obesity according to BMI seems to be accurate in women with BMI > 30 kg/m2. We found only 1% of nonobese subjects (evaluated according to %BFM) in this BMI category. In contrast, there was found a large number of subjects with obesity (evaluated according to %BFM) among women in 18.5 to 24.9 kg/m2 and 25.0 to 29.9 kg/m2 BMI categories. CONCLUSIONS: The results have shown that obesity may be diagnosed in women with lower BMI (i.e., < 30 kg/m2). For this reason we recommend to evaluate the prevalence of obesity primarily from BFM% in this age group.

Postmenopausal obesity: 12,500 steps per day as a remedy? Relationships between body composition and daily steps in postmenopausal women.

INTRODUCTION: To verify relationships between physical activity (steps per day) and obesity (components of body composition) among postmenopausal women. MATERIAL AND METHODS: Physical activity (ActiGraph GT1M accelerometer; worn for 7 days) and obesity (body composition analyzer InBody 720) were assessed among 79 healthy postmenopausal women (age 63.25 ± 5.51 years; range: 51-81 years). In order to determine differences in body composition in women with different levels of physical activity, one-way analysis of covariance (ANCOVA) was conducted, with age of participants as a covariate. RESULTS: Significant intergroup differences in almost all analyzed components of the body composition (weight, body mass index, waist-hip ratio, visceral fat area, body fat mass and percent of body fat) were obtained. Highly active women (≥ 12,500 steps/day) had lower weight and adiposity parameters than those that represented low (< 7,500 steps/day) or somewhat active (7,500-9,999 steps/day) groups. Besides, a noteworthy difference between active (10,000-12,499 steps/day) and low active women was recorded. Noticeably, only in the most active group was the BMI within normal ranges. CONCLUSIONS: The higher physical activity, the lower obesity in postmenopausal women. The recommended 10,000 steps/day seems insufficient for this age group. Based on the obtained results, postmenopausal women should walk at least 12,500 steps per day to improve their health.