Medico-social value of osteoarthritis. secondary prevention and treatment of osteoarthritis in comorbidity with chronic gastritis.

OBJECTIVE: Introduction: Medico-social significance of osteoarthritis is due to a number of factors, one of which is associated with the need for long-term anti-inflammatory therapy, which is associated with undesirable side effects. The aim: Identify the features of the course of chronic gastritis in patients taking selective NSAIDs for osteoarthritis. PATIENTS AND METHODS: Materials and methods: Were examined 122 patients with osteoarthrosis, who had verified chronic gastritis in the anamnesis (50 males and 72 females), aged from 42 to 64. Control group included 40 patients with osteoarthrosis without gastroduodenal zone pathology in the anamnesis. For arthralgia relief, patients were prescribed to intake meloxicam (average dose - 12.5±1.39 mg/day) or nimesulide (average dose - 150±14.91 mg/day). RESULTS: Results: It was determined that prescription of selective NSAIDs (meloxicam and nimesulide) raised the risk of NSAIDs gastropathy/dyspepsia in 2.9 times (P<0.03) in patients with chronic gastritis in the anamnesis than in patients without associated gastroduodenal zone pathology. Atrophy of gastric mucous membrane was associated with higher risks (P>0.05) of erosive gastropathy. CONCLUSION: Conclusions: With the purpose of gastropathy prevention upon taking NSAIDs, patients with chronic gastritis in the anamnesis are recommended to undergo gastroprotective therapy.

Methods of transmission and features of the course of hepatitis c virus infection in children: medical and social aspects.

OBJECTIVE: Introduction: Hepatitis C virus (HCV) infection is a major global problem. According to WHO, 150-200 million people globally have hepatitis C infection. Even though HCV infection morbidity rate in children is relatively low in comparison with the adult population, approximately 5 million children in the world have active HCV. There is a number of differences between HCV infection in adults and in children. However, the data pertaining to this issue is controversial. The aim: Research, analysis and synthesis of information from contemporary literature on transmission of infection and characteristics of the course of HCV infection in children. PATIENTS AND METHODS: Materials and methods: Analysis and synthesis of information from contemporary literature on transmission of infection and characteristics of the course of HCV infection in children were conducted. CONCLUSION: Conclusions: Information from literature of the latest years on peculiarities of infection, disease course and complications of HCV infection in children was analyzed and summarized in this article.