[Inhibiting effect of the polyphenolic complex from Plantago major (plantastine) on the carcinogenic effect of endogenously synthesized nitrosodimethylamine]. / Ingibiruiushchee vliianie polifenol'nogo kompleksa iz podorozhnika bol'shogo--plantastina--na kantserogennyi éffekt éndogenno sintezirovannogo nitrozodimetilamina.

Amidopyrine administered in combination with sodium nitrite in the long-term experiment produces the toxic damage of the liver and tumors in rats in connection with endogenic synthesis of carcinogenic nitrosodimethylamine. The inclusion into the animal diet of the polyphenolic complex from Plantago major--plantastine as an inhibitor of the carcinogen synthesis reduced the toxic damage of the liver that was indicated by normalization of biochemical parameters and also decreased the tumor yield from 87.5% to 33.3%. The data obtained may be the basis for the combined use of plantastine with nitrosated drugs that would contribute to carcinogenesis prevention.

[Biochemical characteristics of major fractions of rat liver cells in dimethylnitrosamine-induced carcinogenesis]. / Biokhimicheskaia kharakteristika osnovnykh fraktsii kletok pecheni krys pri kantserogeneze, indutsirovannom nitrozodimetilaminom.

The report deals with a comparative study of the morphological and biochemical indexes in the fractions of parenchymal and non-parenchymal isolated cells of rat's liver, both intact and treated with a polytropic carcinogen-nitrosodimethylamine (NDMA)-for seven months. A higher susceptibility of parenchymal cells to NDMA was established.