1.
Arzneimittelforschung
; 34(6): 661-3, 1984.
Article
in English
| MEDLINE
| ID: mdl-6541485
ABSTRACT
The chemical synthesis of certain mono- and bis-dialkyltriazenopyrazoles is described. In antitumor studies it was found that none of the compounds produced increase in life span (ILS) of L 1210 bearing mice or inhibition of adenocarcinoma 755 growth above the criteria established. The introduction of a second triazenogroup increases the toxicity of the compounds tested.
Subject(s)
Antineoplastic Agents/chemical synthesis , Pyrazoles/chemical synthesis , Triazenes/chemical synthesis , Adenocarcinoma/drug therapy , Animals , Leukemia L1210/drug therapy , Mice , Pyrazoles/pharmacology , Structure-Activity Relationship , Triazenes/pharmacology
2.
Biochem Pharmacol
; 29(2): 163-6, 1980 Feb.
Article
in English
| MEDLINE
| ID: mdl-7362631