ABSTRACT
A study of 30 patients with infectious-allergic myocarditis, accompanied with chronic heart failure made use of echocardiography, hemodynamic assessment by cardiac catheterization, endomyocardial biopsy. A relationship is demonstrated between hemodynamic changes and the lesion of cellular ultrastructural apparatus, mitochondria, in particular. Patients with first-stage heart failure associated with infectious-allergic myocarditis showed incomplete diastole, while systolic changes were found in patients with severe manifestation of circulatory insufficiency.
Subject(s)
Heart Failure/physiopathology , Hemodynamics , Myocarditis/physiopathology , Myocardium/ultrastructure , Adult , Biopsy , Cardiac Catheterization , Chronic Disease , Electrocardiography , Female , Heart Failure/etiology , Histocytochemistry , Humans , Male , Middle Aged , Myocardial Contraction , Myocarditis/complications , Myocardium/metabolismSubject(s)
Cardiomegaly/pathology , Heart Defects, Congenital/pathology , Myocardial Contraction , Adolescent , Adult , Cardiomegaly/physiopathology , Child , Child, Preschool , Heart Defects, Congenital/physiopathology , Humans , Infant , Microscopy, Electron , Middle Aged , Myocardium/ultrastructureSubject(s)
Heart Defects, Congenital/physiopathology , Heart Diseases/physiopathology , Myocardial Contraction , Myocardium/ultrastructure , Adolescent , Adult , Cardiac Catheterization , Child , Heart Defects, Congenital/surgery , Heart Diseases/surgery , Hemodynamics , Humans , Middle Aged , Postoperative Period , PrognosisABSTRACT
After performing 242 operations on patients with secondary atrial septal defects under conditions of moderate hypothermia, the authors studied the contractile capacity of the myocardium by means of long-term catheterization of the heart chambers in 56 patients. In 35 patients of this group intravital biopsy of the right ventricle was carried out. The bioptic material was subject to light and electron microscopy and histochemical examination. Considerable changes in intracardiac hemodynamics were revealed in patients with bacterial endocarditis. In such cases the diastole changes most sharply: the phase of isometric relaxation was prolonged, and there was a sharp rise in the maximum rate of intraventricular pressure decrease and in the relaxation index, which indicated to disorders of metabolic processes in the myocardium, conducive to the manifestation of myocardial insufficiency.
Subject(s)
Endocarditis, Bacterial/physiopathology , Heart Septal Defects, Atrial/physiopathology , Myocardial Contraction , Adolescent , Adult , Biopsy , Cardiac Catheterization , Child , Child, Preschool , Female , Heart Septal Defects, Atrial/complications , Hemodynamics , Humans , Infant , Male , Middle AgedABSTRACT
Operative treatment of isolated secondary interatrial septal defects in 236 patients is analysed. The results testify to the small degree of risk in suturing interatrial septal defects under conditions of moderate hypothermia. A study of central and intracardiac hemodynamics made it possible to reveal the development of acute pulmonary hypertension in some patients after the operation, which may be of a reflex character or a consequence of left ventricular insufficiency. A differential diagnosis and a therapeutic test are suggested for the differentiation and therapy of these conditions.
