[Morphological and functional aspects of wound regeneration in the treatment by iodine-containing ointments].

The comprehensive morphological investigation indicated a high antimicrobial activity of iodine-containing ointments in the treatment of septic wounds from the first days of the ointments using. 3% ointment "Stellanin-PEG" helps to reduce the local inflammatory changes by activating neutrophils and macrophages. A management of wounds by 3% ointment "Stellanin-PEG" improves their condition by stimulating regeneration, which leads to an intensification of the proliferative and functional activity of granulation tissue. Clinical, morphological and cytological data are evidence of time reduction of relief of purulent process, which leads to an earlier (in comparison with the use of ointment "Betadine") wound epithelization.

[Functional state of stroma and capillaries by chronic pancreatitis].

The straight correlation between the intensity of stroma inflammatory infiltration and the vessel endothelium growth factor (VEGF) was registered. The progression of the pancreatic tissue fibrosis correlated with the decrease of endothelial and fibroblastic activity, increase of perivascular fibrosis and cellular expression of VEGF, as well as the decrease of compensatory capacity of pancreatic cells.

[The diagnostics of adaptive reactions of blood on application the stress-modulating therapy in patients with brain chronic ischemia].

The article deals with the results of analysis of electrophoretic mobility of erythrocytes and leukogram in patients with dyscirculatory encephalopathy on different stages of disease on application therapy with inclusion of stress-modulating pharmaceuticals into course of treatment. It is established that the electrophoretic mobiliy of erythrocytes makes it possible to evaluate the adaptive indicators blood in patients with dyscirculatory encephalopathy. The consideration of these indicators makes feasible the substantiation of inclusion of stress-modulating therapy into complex treatment of patients with chronic cerebrovascular inefficiency.

[Nonspecific adaptive reactions blood in chronic brain ischemia].

Clinical and experimental studies were under way to examine nonspecific adaptive reactions of blood in chronic brain ischemia. The electrophoretic mobility of red blood cells and differential blood count were studied in animals (rats) when simulating local and total brain ischemia, as well as in patients with stages I, II, and III dyscirculatory encephalopathy. General mechanisms responsible for changing the adaptive reactions of blood were found in varying chronic brain ischemia in the experiments and clinical observations. These characterize the activity of the pituitary-adrenal system and the state of an adaptive process in the body.

[The comparative characteristics of pulmonary and renal ultrastructural changes in burn sepsis].

The results of histological and electron microscopic studies of the lung and kidney from the patients who died from burn sepsis are presented. The lung and kidney showed blood circulatory disorders, reversible and irreversible damages, and cell necrosis. The most pronounced changes of lung cells were revealed near coccal bacteria.

[Effect of serotonin-adipinate on the ultrastructure and synthetic activity of endotheliocytes of microhemocirculatory bed of human brain (autopsy material, early autopsies)]. / Vozdeistvie serotonina adipinata na ul'trastrukturu u sinteticheskuiu aktivnost' éndoteleotsitov mikrogemotsirkuliarnogo rusla golovnogo mozga cheloveka.

Electron-microscopic and radioautographic investigation showed the ability of brain capillary endotheliocytes for retaining functional activity in total ishemia. Administration of serotonin adipinate in an early postoperative period supports intracellular processes and plays a protective role.

[Electron-radioautographic study of differential influence of biologically active wound covering on the process of regeneration]. / élektronno-radiographicheskoe issledovanie differentsirovannogo vliianiia biologicheski aktivnykh ranevykh pokrytii ha protsessy regeneratsii.

It is established that local wound treatment with coverings is directed to both suppression of microflora and inflammatory process and stimulation of regeneration at early periods of wound healing, this favouring granulation tissues growth and wound epithelization. Mechanism of biologically active covering influence on the reparative regeneration lies in stimulation of fibroblast, endotheliocyte and pericyte proliferation and stimulation of granulation tissue cells functional activity.

Specific effect of epidermal growth factor immobilized on wound coating with soluble collagen on healing of experimental wounds.

Electron-microscopy and autoradiography of granulation tissue in wounds showed that bioactive coating with epidermal growth factor activates functional and proliferative processes in vascular cells (endotheliocytes and pericytes) and fibroblasts and increases the number of cell-to-cell contacts on days 2-3 of therapy. Pronounced activation of proliferative processes resulted in early differentiation of fibroblast cells (on days 3-4) and rapid epithelialization of the wound.

[The survivability time of central nervous system cells]. / Vremia perezhivaemosti kletok tsentral'noi nervnoi sistemy.

Our investigations show that vital functions of some neurons and glial cells may survive for 4-8 hours after death and disappear in parallel with destructive changes in cells. Up-to-date morphological techniques demonstrate that neurons and other cells of the CNS preserve biological activity not for several minutes as believed so far but up to 4-8 hours. It is too early to judge about functional importance of this phenomenon and further investigations into this problem are necessary. Temporal parameters of RNA synthesis in the brain cells give additional knowledge about CNS cells survival and this may be of interest for reanimatology and transplantology.

[An electron radioautographic study of the dynamic decrease in the level of RNA synthesis in human brain cells at different times after death]. / Elektronno-radioavtograficheskoe izuchenie dinamiki snizheniia urovnia sinteza RNK v kletkakh golovnogo mozga v razlichnye sroki posle smerti.

The above study is performed in neurons, oligodendrocytes and capillary endotheliocytes of human brain 4-13 hours after death. Brain biopsies after the surgery and early necropsies served as the material. RNA synthesis in some neurons and glial cells is retained to some degree 8-13 hours after death. Oligodendrocytes are more and neurons less resistant. Grave disturbances of the CNS microcirculation is the obstacle to reversibility of destructive processes.

[The dynamics of the extinction of brain cellular biosynthesis at different times after death]. / Dinamika ugasaniia biosinteza kletok mozga v razlichnye sroke posle smerti.

The paper presents experimental data on RNA synthesis in neuronal, glial, endothelial cells of a dying organism. Under certain conditions it is possible to define labelled cells in the majority of the brain cells within post-death hours 1-4. This fact proves that genome is still functioning. Endothelial cells possess higher vital capacity. CNS neurons are capable of synthesizing RNA within the period of up to 4 hours after death of the organism.

[Electron-radioautographic study of cell viability of the human heart after death of the body]. / Elektronno-radioavtograficheskoe issledovanie zhiznesposobnosti kletok serdtsa cheloveka posle smerti organizma.

Human heart cells RNA-synthesis was investigated by electron-microscopic radioautography in the 3rd, 4th, 8th and 13th hour after death. In many blood vessels cells and in some myocytes via creation of adequate regimen a capacity to restore RNA-synthesis persevered for 8-13 hours after death.

[An electron microscopic radioautographic study of the viability of human cells after death. The postmortem activation of RNA synthesis in neutrophils]. / Elektronno-radioavtograficheskoe issledovanie zhiznesposobnosti kletok cheloveka posle smerta. Posmertnaia aktivatsiia sinteza RNK v neitrofilakh.

RNA synthesis in human neutrophils isolated from blood 2.5-67 hours after death of patients was studied by means of light and electron microscopy radioautography. The rate of RNA synthesis in neutrophils isolated from blood of cadavers was higher in comparison with the same parameter in neutrophils isolated from survivor's blood. The significance of this observation for resuscitation and transplantology is discussed.

[Clinical aspects and pathogenesis of Tolosa-Hunt syndrome]. / K klinike i patogenezu sindroma Tolosy-Khanta.

The authors describe two cases of the Tolosa-Hunt syndrome and come to the conclusion that the pathological process in the disease (largely in the meninges) may also involve other sites located distantly from the cavernous sinus. The genesis of this syndrome appears to be largely infectious-allergic in nature.