ABSTRACT
Acute period of stroke is a crucial stage of the disease. The differential therapy in the first 3-6 h from the onset of acute ischemic stroke, so-called "therapeutic window", is of special importance. Obviously, favorable clinical outcome in such patients is largely depends on the early recanalization during "therapeutic window". Presented, are the results of intra-arterial thrombolysis in patients with ischemic stroke, which reveal its high therapeutic effectiveness. Though there was limited clinical evidence for a high effect of recanalization of intra-arterial thrombolysis, this approach opens new perspectives for large scale clinical investigations using endovascular methods in thrombolytic therapy of patients with ischemic stroke.
Subject(s)
Brain Ischemia/drug therapy , Emergency Service, Hospital , Fibrinolytic Agents/administration & dosage , Thrombolytic Therapy/methods , Adult , Aged , Brain Ischemia/diagnosis , Brain Ischemia/physiopathology , Cerebral Angiography , Cerebrovascular Circulation/drug effects , Female , Fibrinolytic Agents/therapeutic use , Follow-Up Studies , Humans , Injections, Intra-Arterial , Male , Middle Aged , Time Factors , Tomography, X-Ray Computed , Treatment Outcome , Ultrasonography, Doppler, Transcranial , UzbekistanABSTRACT
Somatosensory evoked potentials (SSEP) on n. medianus and n. tibialis stimulation were studied in 25 patients with multiple sclerosis (MS) and 30 normals (N). Sensory conduction velocity (SVC) calculated by indirect method using formula of Eisen and Nudelman (1979) in which instead of time parameters of F- and M-responses latencies of the N13 and N21 for hand and leg, respectively, of spinal SSEP was used. Normal spinal cord SCV was 60.8 +/- 1.3 m/s, SCV in MS was 51.9 +/- 10.7 m/s. Extreme dispersion of data in MS is caused by false "normal and paradoxically "increased" SCV values in patients. The causes of false results are analysed. In difference of Eisen and Nudelman methods, the proposed approach allows proper clinical interpretation of the false values and excludes possibility of diagnostic mistakes, as in each case the whole set of the data from cerebral and spinal SSEP is interpreted systematically.
Subject(s)
Evoked Potentials, Somatosensory/physiology , Median Nerve/physiopathology , Multiple Sclerosis/physiopathology , Neural Conduction/physiology , Spinal Cord/physiopathology , Synaptic Transmission/physiology , Tibial Nerve/physiopathology , Diagnostic Errors , Electric Stimulation , Humans , Multiple Sclerosis/diagnosis , Time FactorsSubject(s)
Evoked Potentials, Somatosensory/physiology , Neurophysiology/trends , Spinal Cord/physiology , Syringomyelia/physiopathology , Electric Stimulation , Humans , Median Nerve/physiology , Median Nerve/physiopathology , Spinal Cord/physiopathology , Syringomyelia/diagnosis , Tibial Nerve/physiology , Tibial Nerve/physiopathologyABSTRACT
Inborn analgesia (IA) is described in 3 members of a family: a 14 month-old girl, hel father and grandfather on the paternal line. Generalized indifference to pain and visceral analgesia with other senses intact was noted in all patients since birth. Profound reflexes, intellectual development, karyotype, motor and sensory nervous excitation propagation velocities, somatosensory evoked potentials were all normal. Notedly, the IA inheritance was found to be autosome-dominant in this family.
