ABSTRACT
Experiments on 20 dogs with simultaneous recording of bioelectrical activity of the brain cortex, medial thalamus, heart, arterial pressure, respiration and oxygen tension in brain tissues have shown that purposive correction of arterial hypotension with the aid of pharmacological substances, particularly fetanol increases the resistance of the brain cortex and respiratory center, thereby raising the animals' tolerance of increasing ftorotan anesthesia.
Subject(s)
Etilefrine/pharmacology , Halothane , Phenylephrine/analogs & derivatives , Animals , Blood Pressure/drug effects , Dogs , Drug Tolerance , Electroencephalography , Vascular Resistance/drug effectsABSTRACT
Tests conducted with dogs by using Pavlov's method of conditioned reflexes (salivation procedure) showed fluothane to act on the central nervous system 3 times as strong as does ether. This is confirmed by a longer time necessary for the higher nervous system to normalize. Thus, awakening of the animals after the ether anesthesia, the re-establishment of the conditioned reflex activity supervened by the 7th day on the average, whereas, after the fluothane anesthesia, this occurred only on the 24th day.
Subject(s)
Ether/pharmacology , Ethyl Ethers/pharmacology , Halothane/pharmacology , Higher Nervous Activity/drug effects , Animals , Conditioning, Classical/drug effects , Dogs , Female , Inhibition, Psychological/drug effects , Male , Respiration/drug effects , Time FactorsABSTRACT
In tests staged on 35 cats it was established that chloroform and fluothane display the biological activity which is 5 times as high as that of ether with respect to the brain cortex neurons. The reactive properties of individual neurons of the brain cortex are dissimilar and this, other conditions of anesthetization being equal, determines their unequal resistance to the action of anesthetics.
