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1.
Biology (Basel) ; 13(5)2024 May 16.
Article in English | MEDLINE | ID: mdl-38785832

ABSTRACT

Rhabdoid meningiomas (RM) are a rare meningioma subtype with a heterogeneous clinical course which is more frequently associated with recurrence, even among tumors undergoing-complete surgical removal. Here, we retrospectively analyzed the clinical-histopathological and cytogenetic features of 29 tumors, from patients with recurrent (seven primary and 14 recurrent tumors) vs. non-recurrent RM (n = 8). Recurrent RM showed one (29%), two (29%) or three (42%) recurrences. BAP1 loss of expression was found in one third of all RM at diagnosis and increased to 100% in subsequent tumor recurrences. Despite both recurrent and non-recurrent RM shared chromosome 22 losses, non-recurrent tumors more frequently displayed extensive losses of chromosome 19p (62%) and/or 19q (50%), together with gains of chromosomes 20 and 21 (38%, respectively), whereas recurrent RM (at diagnosis) displayed more complex genotypic profiles with extensive losses of chromosomes 1p, 14q, 18p, 18q (67% each) and 21p (50%), together with focal gains at chromosome 17q22 (67%). Compared to paired primary tumors, recurrent RM samples revealed additional losses at chromosomes 16q and 19p (50% each), together with gains at chromosomes 1q and 17q in most recurrent tumors (67%, each). All deceased recurrent RM patients corresponded to women with chromosome 17q gains, although no statistical significant differences were found vs. the other RM patients.

4.
Clin Exp Dermatol ; 47(9): 1748-1751, 2022 Sep.
Article in English | MEDLINE | ID: mdl-35692107

ABSTRACT

Bacillary angiomatosis is a vasculoproliferative infectious disease mostly recorded in patients with human immunodeficiency virus and rarely in organ transplant recipients. We report the first case of bacillary angiomatosis due to Bartonella quintana in a paediatric renal transplant patient with skin, lymph node and bone involvement with excellent response to doxycycline. Click here for the corresponding questions to this CME article.


Subject(s)
Angiomatosis, Bacillary , Bartonella quintana , Kidney Transplantation , Skin Diseases , Child , Doxycycline , Humans , Kidney Transplantation/adverse effects , Skin Diseases/drug therapy , Transplant Recipients
6.
BMC Pulm Med ; 10: 54, 2010 Nov 05.
Article in English | MEDLINE | ID: mdl-21054856

ABSTRACT

BACKGROUND: Kikuchi-Fujimoto's disease (KFD), also called histiocytic necrotizing lymphadenitis, is a rare, idiopathic and self-limited condition usually characterized by cervical lymphadenopathy and fever, most often affecting young patients. Aetiology is unknown. Differential diagnosis includes mainly malignant lymphoma, tuberculous lymphadenitis and systemic lupus erythematosus (SLE), so early diagnosis is crucial. Pleuropulmonary involvement due to isolated KFD has been seldom reported. CASE PRESENTATION: a 32-year-old man, on treatment for iatrogenic hypothyroidism, was admitted due to high grade fever and painful cervical lymphadenopathies. KFD was diagnosed by lymph node biopsy. Some days after admission the patient got worse, he developed generalized lymphadenopathy, bilateral pleural effusion and interstitial lung disease. All of them resolved with prednisone and after two years of following up he remains asymptomatic and without evidence of any other associated disease. CONCLUSION: Pleural effusion and interstitial lung disease are very uncommon manifestations of KFD. In our experience, treatment with oral prednisone was effective.


Subject(s)
Histiocytic Necrotizing Lymphadenitis/complications , Lung Diseases, Interstitial/diagnosis , Lung Diseases, Interstitial/etiology , Pleural Effusion/diagnosis , Pleural Effusion/etiology , Administration, Oral , Adult , Biopsy , Glucocorticoids/administration & dosage , Glucocorticoids/therapeutic use , Histiocytic Necrotizing Lymphadenitis/drug therapy , Histiocytic Necrotizing Lymphadenitis/pathology , Humans , Lung Diseases, Interstitial/drug therapy , Lymph Nodes/pathology , Male , Pleural Effusion/drug therapy , Prednisone/administration & dosage , Prednisone/therapeutic use , Treatment Outcome
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