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Bull Exp Biol Med ; 148(3): 514-7, 2009 Sep.
Article in English, Russian | MEDLINE | ID: mdl-20396727

ABSTRACT

Experimental NO deficiency induced by L-NAME injection led to the development of arterial hypertension, endothelial dysfunction, and cardiomyocyte hypertrophy and reduced blood content of nitrates and nitrites. Impaza, NO donors, activators of NO-synthase, antioxidants, and antihypertensive preparations produced endothelium-protective effect of different degree.


Subject(s)
Antibodies/therapeutic use , Endothelium, Vascular/drug effects , Nitric Oxide/deficiency , Animals , Antihypertensive Agents/therapeutic use , Antioxidants/therapeutic use , Hypertension/chemically induced , Hypertension/drug therapy , Male , NG-Nitroarginine Methyl Ester/pharmacology , Nitrates/metabolism , Nitric Oxide Donors/therapeutic use , Nitrites/metabolism , Rats , Rats, Wistar , Resveratrol , Stilbenes/therapeutic use
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