ABSTRACT
Double-hit lymphoma (DHL) has been identified as a subset of diffuse large B-cell lymphoma with poor clinical outcomes. It is because of genetic translocation of C-myc and Bcl2 gene that make it more aggressive and un-responsive to conventional and salvage treatments. DHLis an extremely rare entity of non-Hodgkin's lymphoma (NHL) having no established incidence data so far. In literature very limited data is available to guide therapeutic decisions and despite aggressive chemotherapy followed by autologus hematopoietic cell transplantation, outcomes still remain poor. Herein, we report a case of 82-year Pakistani patient who presented with left groin lump. Incision biopsy established the diagnosis of DHL. Despite intensive course of standard chemotherapy and radiation therapy, he died with progression of disease.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Non-Hodgkin/drug therapy , Aged, 80 and over , Fatal Outcome , Humans , Lymphoma, Large B-Cell, Diffuse/pathology , Lymphoma, Non-Hodgkin/pathology , Male , Rare DiseasesABSTRACT
We report a case of 15 year old female patient of xeroderma pigmentosum with large squamous cell carcinoma on the left side of cheek. She received combination chemotherapy with isotretinoin for a period of 4 months and showed complete clinical remission of tumour. The role of isotretinoin in cancer prevention and management of malignancies associated in xeroderma pigmentosum is also reviewed through literature.
