ABSTRACT
The COVID-19 pandemic has represented a major cause of morbidity/mortality worldwide, overstressing health systems. Multiple myeloma (MM) patients show an increased risk for infections and they are expected to be particularly vulnerable to SARS-CoV-2 infection. Here we have obtained a comprehensive picture of the impact of COVID-19 in MM patients on a local and a global scale using a federated data research network (TriNetX) that provided access to Electronic Medical Records (EMR) from Health Care Organizations (HCO) all over the world. Through propensity score matched analyses we found that the number of new diagnoses of MM was reduced in 2020 compared to 2019 (RR 0.86, 95%CI 0.76-0.96) and the survival of newly diagnosed MM cases decreased similarly (HR 0.61, 0.38-0.81). MM patients showed higher risk of SARS-CoV-2 infection (RR 2.09, 1.58-2.76) and a higher excess mortality in 2020 (difference in excess mortality 9%, 4.4-13.2) than non-MM patients. By interrogating large EMR datasets from HCO in Europe and globally, we confirmed that MM patients have been more severely impacted by COVID-19 pandemic than non-MM patients. This study highlights the necessity of extending preventive measures worlwide to protect vulnerable patients from SARS-CoV-2 infection by promoting social distancing and an intensive vaccination strategies.
Subject(s)
COVID-19/epidemiology , Multiple Myeloma/epidemiology , Adult , Female , Global Health/statistics & numerical data , Humans , Male , Middle Aged , SARS-CoV-2ABSTRACT
Intravesical instillation of bacillus Calmette-Guérin is the elective treatment for transitional cell and in situ bladder carcinoma. Severe complications occur very seldom but must be known and promptly recognized. We present a case of miliary tuberculosis reactivation secondary to the mentioned treatment.
Subject(s)
Adjuvants, Immunologic/adverse effects , BCG Vaccine/adverse effects , Tuberculosis, Miliary/chemically induced , Adjuvants, Immunologic/administration & dosage , Administration, Intravesical , Aged , BCG Vaccine/administration & dosage , Carcinoma, Transitional Cell/drug therapy , Humans , Male , Urinary Bladder Neoplasms/drug therapyABSTRACT
La instilación endovesical con bacilo de Calmette-Guerin es el tratamiento de elección para el carcinoma superficial e in situ de vejiga. En raras ocasiones presenta complicaciones graves que deben ser tenidas en cuenta. A continuación presentamos un caso de reactivación endógena de tuberculosis miliar secundaria a dicho tratamiento
Intravesical instillation of bacillus Calmette-Guérin is the elective treatment for trnasitional cell and in situ bladder carcinoma. Severe complications occur very seldom but must be known and promptly recognized. We present a case of miliary tuberculosis reactivation secondary to the mentioned treatment
