The apoptosis of the rat and mouse testicular cells could be induced by synthetic analogous of the prostaglandin F2 alpha?

Numerous actions of the synthetic analogous of the prostaglandins were used in human and veterinary therapy. The action of these analogous (even, initially the prostaglandins were put in evidence in the seminal plasma) on the male reproductive system are little known. This is the reason for our study, which tried to emphasize the effects of analogous of the prostaglandin F2 alpha on the apoptosis of the rat and mouse testicular cells. Optic active Cloprostenol and Cloprostenol Isopropyl ester, in a dose of 100 micrograms/kg/day induces significant histopathologic modifications in the testis of rats and mice. These changes are evident after 14 days of treatment, but especially after 28 days of treatment.

[Phenytoin influence on human metanephros]. / Influenta fenitoinei asupra metanefrosului uman.

The influence of Phenytoin on the human embryo is knowing to produce the fetal hydantoin syndrome. Even this syndrome is knowing to produce microcephaly, mental retardation, eyelid ptosis etc it is not mentioned the influence of Phenytoin on the human metanephros. This is the reason of our study, made on human embryos. Their mothers received during pregnancy Phenytoin. In one studied embryo we have remarked a malformation in the metanephros. Even we can not make a strong correlation between the malformation and the Phenytoin we consider that pregnant women should not use Phenytoin during pregnancy.

[The influence of some synthetic prostaglandin F2alpha analogous on rat lung]. / Influenta unor analogi sintetici ai prostaglandinei F2 alpha asupra pulmonului la sobolan.

The role of prostaglandins and their synthetic analogous at the level of the female genital system is multiple. The synthetic analogous of the prostaglandin F2 alpha are utilised in a large area of treatments, for multiple purposes, but their influence on the lung is not so well known. The study was made on 2 lots with 12 non pregnant female rats: the first lot was the witness lot and didn't receive any substance. The second lot received 25 micrograms/kg/day Flavoliz (synthetic analogous of the prostaglandin F2 alpha). The prostaglandinic analogous produces vasodilating effects on the lung blood vessels and moderate pulmonary destruction.