[The effect of environmental factors on the concentration of tumor markers in the blood serum and on the indices characterizing thyroid function]. / Vliianie nekotorykh faktorov okruzhaiushchwei sredy na kontsentratsiiu v syvorotke krovi opukholevykh markerov i pokazateli, kharakterizuiushchie sostoianie shchitovidnoi zhelezy.

Combined versus separate exposure of male organism to cesium-137 and chemical agents results in a more pronounced hyperferritinemia in the former case. In female chemists the ferritin level is dependent to a considerable extent on the menstrual cycle showing a tendency for the iron-containing protein level to decrease because of the action of a number of chemical agents. The rise of the level of cancer embryonic antigen is more readily seen in persons with high levels of cesium-137. Concentrations of carbohydrate antigen (CA-125) and mucin-like antigen are appreciably higher in female chemists incorporating cesium-137, and in those within the 30-km radius of the ChNPP. The level of thyroglobulin was raised in the chemists having a background incorporation of cesium, the liquidators of the aftermaths, and particularly in those happened to be in the 30-km zone. Each of the unfavourable factors taken separately (chemical agent or cesium-137) had lesser effect on the degree of elevation of TG content and hormone-forming function of the thyroid gland. An additional information has been obtained concerning the risk groups, which, however, serves as an indirect measure of carcinogenic effect various environmental factors exert on the organism.

[Changes in the levels of tumor markers in those working with different chemically active substances]. / Izmenenie urovnei opukholevykh markerov u rabotaiushchikh s razlichnymi khimicheski aktivnymi veshchestvami.

Groups at risk for malignant neoplasia were identified among workmen occupationally exposed to different chemical substances, using immunoradiometric and enzyme immunoassays of tumor-associated antigens. Exposure to the above occupational hazard was found to affect the workmen and cause certain chronic illness accompanied by some increase in concentration of a number of tumoral markers. Increase in tumour antigens suggests indirectly that the chemical substances may have carcinogenic activity. We have every reason to recommend these tests as an additional method for identification of groups at high risk for subsequent development of tumours in the digestive system and reproductive organs of persons occupationally exposed to chemical substances.

[Changes in the beta 2-microglobulin levels of the blood serum in patients with benign and malignant neoplasms]. / Izmenenie urovnia beta 2-mikroglobulina v syvorotke krovi bol'nykh s dobrokachestvennymi i zlokachestvennymi novoobrazovaniiami.

Radioimmunological examination of beta 2-microglobulin in the blood serum of 525 patients revealed that increased protein levels were observed in patients with malignant tumours of the pancreas, duodenal papilla, ovaries, soft tissues, lymphomas. In benign diseases (pancreatitis, ovarian cysts) the beta 2-microglobulin concentration did not significantly exceed the discrimination value. Due to the low sensitivity and specificity this protein has dubious significance as a tumour marker. It is suggested that in some cases of malignant tumours changes of the beta 2-microglobulin level may be related to hepatorenal insufficiency, spread of the disease. These data may provide supplementary information on the prognosis and evolution of the tumour process after combined treatment.

[Accumulation and localization of 67Ga citrate in cancerous lung tissue during diagnostic use of the preparation]. / Nakoplenie i lokalizatsiia 67Ga-tsitrata v opukholevoi tkani legkikh pri diagnosticheskom ispol'zovanii preparata.

Altogether 89 patients were examined using scintigraphy with 67Ga-citrate. Radiometric, scintigraphic, radioautographic and histological investigation of the operation material of 15 patients was conducted. The diagnostic accuracy was 92.1%, sensitivity 98.6%, specificity 75%. The investigation of the operation material showed that RP accumulation in the peripheral part of tumor was 4-4.5 times higher and in its central part 2-3 times higher than in the unaffected pulmonary tissue. Elevated RP accumulation was found in the capsular wall in inflammatory processes as well as in lymph nodes with anthracosis. Recovered silver grains on histoautoradiograms of tumor tissue zones were mainly localised around isolated cells and their groups in the intercellular space.