Permanent 125iodine implants for recurrent malignant gliomas.

PURPOSE: To determine the efficacy and toxicity of permanent 125iodine implants for recurrent malignant gliomas. METHODS AND MATERIALS: Between January 1989 and January:, 59 patients with histologically confirmed recurrent malignant gliomas (22 nonglioblastoma malignant gliomas, 37 glioblastoma multiforme at the time of implant) received a permanent 125iodine implant. Patients ranged in age from 13-74 years. The median ages for the overall group, nonglioblastoma (nonGBM), and glioblastoma (GBM) groups was 47 years, 39 years, and 53 years, respectively. RESULTS: With a median follow-up of 40 months, the median survival for the 59 total patients is 1.34 years; nonGBM 2.04 years, GBM 0.9 years. Factors predictive for poor prognosis were GBM histology, age 60 years or more, target volume 17 cc or more, and/or tumor location within the corpus callosum or thalamus. Reoperations have been performed in 24 (40%) patients; 15 (25%) for tumor progression; 3 (5%) for radiation necrosis; 2 (3%) for skull necrosis/infection, and 4 (7%) for other reasons (Ommaya reservoir insertion, catheter removal, hematoma evacuation). CONCLUSION: Permanent 125iodine implants in selected patients with recurrent malignant gliomas are associated with reasonable long-term survival and a low risk of complications. Given the low incidence of radiation necrosis, future plans are to increase dose rate and/or total dose delivered with the permanent implant.

Image-guided insertion of transpedicular screws. A laboratory set-up.

STUDY DESIGN: A computer-assisted system allowing precise preoperative planning and real-time intraoperative image localization of surgical instruments is tested in a laboratory setup. OBJECTIVES: The purpose of this study is to assess the applicability, functionality, and accuracy of this transpedicular spinal fixation technique. SUMMARY OF BACKGROUND DATA: Most techniques in transpedicular spinal fixation rely on the identification of predefined targets with the help of anatomic landmarks and on the intraoperative use of image intensifiers. Various studies report considerable screw misplacement rates which may lead to serious clinical sequelae such as permanent nerve damage. METHODS: The proposed system was tested in an in vitro setup drilling 20 pedicle pilot holes in lumbar vertebrae. The accuracy was assessed using precision cuts through the pedicles and simulation of a 6-mm pedicle screw insertion. RESULTS: An ideal screw position was found in 70 of 77 cuts, and in no case was an injury to the pedicular cortex observed. CONCLUSIONS: The presented technique provides a safe, accurate, and flexible basis for transpedicular screw placement in the spine. This approach should be further evaluated in clinical applications.

Interactive intraoperative localization using an infrared-based system.

Conventional stereotactic surgery has evolved from a ring-based system with a simple software which calculated few parameters to frameless intraoperative localization systems that provide the surgeon with real-time localization and correlation with several imaging modalities. The localization system described in this paper is an opto-electronic system that uses infrared emitters and three precalibrated CCD cameras. The system was chosen among others for the following reasons: it tracks target points defined by up to 256 miniature light emitting diodes, and its accuracy in locating the spatial position of a diode marker in the operating volume 1.0 x 1.0 m at a distance of 2.0 m is 0.1 mm with a resolution better than 0.01 mm. Systems like this one can track and define the position and orientation of any object in the field view of the camera. This is done by attaching a few small infrared emitters (light emitting diodes) to the surface of each 'rigid body' (surgical instrument) being tracked. Subsequently, through a calibration process a corresponding rigid body file is created. This rigid body file represents this particular object (i.e. surgical tool, microscope) and defines a local coordinate system that identifies each translation and orientation of that tool with respect to the camera coordinate system. This in turn is transferred into the computed tomographic/magnetic resonance imaging coordinate system by a process referred to as coordinate matching. Fiducial markers are placed on the patient's head prior to image scanning.(ABSTRACT TRUNCATED AT 250 WORDS)

Interactive intraoperative localization using an infrared-based system.

We discuss new methods of localizing and treating brain lesions for both the conventional method of a base-ring fixed to the patient's skull (referred to as frame-based procedures) and the new method of frameless procedures (no base ring). Frame-based procedures are used for finding a precise instrument position during neurosurgical procedures, such as stereotactic biopsy of deep-seated lesions, placing electrodes for functional stereotaxis or catheters with radioactive seeds for brachytherapy, or even the placement of a stereotactic retractor or endoscope for removal or internal decompression of lesions. In such procedures, the intraoperative image localization of instruments becomes useful as it tracks instruments as they travel through the preplanned trajectory. Additional intraoperative digitization of surgical instruments, e.g., bipolar suction, biopsy forceps, microscope, ultrasound probe, etc, can be achieved during the stereotactic resection of eloquent areas or deep intracranial lesions by adding an infrared-based system. Frameless procedures broaden the range of surgical approaches, image guidance planning, and operative procedures, since no ring is attached to the patient's head which might interfere with the surgical approach, and offers logistic advantages in scheduling diagnostic studies. Frameless diagnostic studies employ anatomical markers and/or surface matching techniques for data registration in the computer software surgical preplanning program. This simplifies scheduling of the procedures since the image study does not need to be acquired the same day as surgery. Frameless diagnostic studies allow for the use of more than one type of imaging data for planning and optimization of surgical procedures, and greatly improve patient tolerance and comfort during these procedures and during surgery, as compared with frame-based procedures.(ABSTRACT TRUNCATED AT 250 WORDS)

Sturge-Weber-Dimitri disease? In association with an astrocytoma.

A patient with parieto-occipital cortical calcification characteristic of Sturge-Weber-Dimitri disease (SWDD) is of interest in that she lacked the facial portwine lesion and almost all other features of the disease. She subsequently developed an astrocytoma in the underlying white matter. Although the absence of the facial lesion in SWDD has previously been described, there has been no report of a glioma developing in such a patient. The association of SWDD and astrocytoma in this case most likely has been fortuitous.