[Use of partusisten in prevention of hyperkalemia in patients with chronic glomerulonephritis with initial forms of renal failure]. / Primenenie partusistena dlia borby s giperkaliemiei u bol'nykh khronicheskim glomerulonefritom s nachal'nymi formami pochechnoi nedostatochnosti.

The studies performed proved the ability of the drug partusisten (in a dose of 10 mg/day) to effectively reduce an elevated potassium level in the serum of chronic sufferers with glomerulonephritis and initial renal insufficiency. Normal concentrations of Ca, K and Na in relevant patients remained unchanged except a slight rise in K urinary excretion this suggesting an extrarenal mechanism of K redistribution consequent to the action of beta 2-adrenergic agents.

[The ability of partusisten to improve kidney excretory function in the initial stage of kidney failure in patients with chronic glomerulonephritis]. / Sposobnost' partusistena uluchshat' ékskretornuiu funktsiiu pochek pri nachal'noi pochechnoi nedostatochnosti u bol'nykh khronicheskim glomerulonefritom.

To assess the effect of partusisten (fenoterol) on excretory function of the kidneys, the drug was administered per os in a dose of 10 mg/day for 7-10 days in 17 chronic glomerulonephritis patients with initial forms (stages I-IIA) of renal failure. A dramatic increase of glomerular filtration, a certain rise of tubular reabsorption, a reduction of blood concentration of nitrous residues were revealed, which was accompanied by electrolyte shifts and hemodynamic changes characteristic of partusisten. It is concluded that partusisten can be used as a drug ameliorating excretory function of the kidneys in chronic glomerulonephritis patients with initial forms of chronic renal failure.

[Effect of innervation and hormones on enzyme activation and synthesis]. / Vliianie innervatsii i gormonov na aktivnost' i sintez fermentov.

Data from the literature and own ones indicate the key role of the nervous system in regulation of the activity and synthesis of the enzymes of energy metabolism in skeletal muscles. Hepatic cells are highly sensitive both to regulation of their metabolism by the vegetative, especially sympathetic nervous system, and hormonal regulation. The enzymic activity and metabolism in the kidneys are controlled mainly by hormones and are not subjected or poorly monitored by the nervous system. Hormonal regulation of the enzymic activity in the bone marrow is presumably rather poor, whereas the question of nervous regulation of its metabolism remains nuclear.