ABSTRACT
BACKGROUND: Formerly, Arcanobacterium pyogenes was recently renamed Trueperella pyogenes. This opportunistic bacterium is related to miscellaneous pyogenic infections in animals. Most studies involving T. pyogenes are case reports, whereas few surveys have focused the major aspects of T. pyogenes infections involving a case series study design. OBJECTIVE: The aim of this study was to retrospectively evaluate selected epidemiological and clinical aspects, as well as the in vitro antimicrobial susceptibility pattern of 144 cases of T. pyogenes infections among domestic animals from 2002 to 2012. ANIMALS AND METHODS: T. pyogenes was isolated from different clinical specimens from cattle, goats, sheep, pigs, horses, dogs, and buffaloes. Correlations were assessed by the Chi-square or Fisher's exact tests. RESULTS: Mastitis (45.1%), abscesses (18.0%), pneumonia (11.1%), and lymphadenitis (9.0%) were the most common clinical manifestations. In addition, the organism was also isolated from other miscellaneous clinical specimens from cases of septicemia, encephalitis, pyometra, prostatitis, orchitis, seminal vesiculitis, pericarditis, and omphalitis. No statistical association was observed between T. pyogenes infections and age, gender, or season across the study. The most effective drugs against the pathogen were florfenicol (99.1%), cefoperazone (96.0%), cephalexin (95.0%), and ceftiofur (94.8%). High resistance rates were observed against trimethoprim-sulfamethoxazole (49.3%), followed by norfloxacin (10.9%) and tetracycline (9.2%). CONCLUSIONS: This study highlights the diversity of clinical manifestations and the opportunistic behavior of T. pyogenes infections in domestic animals, with predominance of mastitis, abscesses, pneumonia, and lymphadenitis. It also reinforces the importance of knowing the susceptibility profile before initiating therapy, to improve antimicrobial therapy approaches.
Subject(s)
Actinomycetales Infections/veterinary , Buffaloes/microbiology , Cattle Diseases/epidemiology , Cattle Diseases/microbiology , Dog Diseases/epidemiology , Dog Diseases/microbiology , Goat Diseases/epidemiology , Goat Diseases/microbiology , Sheep Diseases/epidemiology , Sheep Diseases/microbiology , Swine Diseases/epidemiology , Swine Diseases/microbiology , Actinomycetales Infections/epidemiology , Animals , Animals, Domestic , Arcanobacterium/isolation & purification , Brazil/epidemiology , Cattle , Dogs , Female , Goats , Male , Mastitis, Bovine/epidemiology , Mastitis, Bovine/microbiology , Pneumonia/epidemiology , Pneumonia/microbiology , Pneumonia/veterinary , Retrospective Studies , Seasons , Sheep , SwineABSTRACT
An uncommon outbreak of mastitis caused by Arcanobacterium pyogenes in 26 cows is reported. The epidemiological findings, clinical signs, microbiological exams, somatic cell count, in vitro susceptibility profile of strains, efficacy of intramammary treatment and control measures were discussed. Florfenicol (96.2 percent), cefoperazona (92.3 percent), cefaloxin (84.6 percent) and ceftiofur (84.6 percent) were the most effective antimicrobials, and neomicin (27.0 percent) and enrofloxacin (17.4 percent) the least effective antimicrobials.
