ABSTRACT
Objective: We report the effect of COVID-19 confinement on some psychological variables associated with mental health: Stress perception, types of coping strategies during crises, and some components related to resilience. Method: A national sample of the Mexican population was considered in a total of 2775 people whose ages ranged from 15 years and older. Questionnaires that met the psychometric criteria (reliability and validity) to be used in Latino samples were used. Results: The results showed that older people experienced less stress and displayed more efficient coping behaviors. Discussion: Regarding the exploration of some components associated with resilience, it was found that family constitutes an important interpersonal resource for coping with the crisis related to confinement due to the COVID-19 pandemic. In the future, it is proposed to make comparisons of the psychological factors evaluated to detect and analyze possible fluctuations due to the prevalence of epidemic conditions.
Subject(s)
COVID-19 , Humans , Aged , Pandemics , Mexico/epidemiology , Reproducibility of Results , SARS-CoV-2 , Adaptation, PsychologicalABSTRACT
PURPOSE OF REVIEW: The prognosis of pediatric patients who present with metastatic or recurrent sarcomas remains poor. In this review, we summarize the advances in the management of metastatic and relapsed pediatric sarcoma by highlighting recent and future clinical trials. RECENT FINDINGS: Research into the identification of novel therapies for refractory pediatric sarcomas continues to advance. Outcomes have not improved in several decades underlying a need for improved understanding of the biology behind these tumors and the identification of novel therapeutic molecular targets that can be exploited pharmacologically. Multiple challenges remain for novel therapy in sarcomas such as the selection of effective targets, management of toxicities, and the tumor microenvironment. Many unique challenges remain in the treatment of patients with refractory pediatric sarcomas. Multiple strategies and targets are under investigation that hold promise.
