Evaluation of Bis-GMA/TEGDMA monomers leaching from a hybrid dental composite resin.

AIM: Postcuring elution of unreacted monomers has harmful effects on mechanical characteristics and biocompatibility of resin composite restorations. The purpose of this study was to evaluate the amount of eluted Bis-GMA and TEGDMA monomers from a hybrid dental composite cured with LED or halogen curing unit after immersing in saliva or water. METHODS: Thirty-six composite disc specimens (Hybrid Filtek Z250,3M-ESPE, USA) were made and divided in four groups. After polymerization with LED or halogen curing units, samples were immersed in water or saliva for 24 hours. The amounts of each monomer (Bis-GMA and TEGDMA) released in different mediums were detected by high-performance liquid chromatography (HPLC). Data were analyzed with two-way ANOVA and one-way ANOVA tests. RESULTS: The samples were immersed in water, in both curing methods, released significantly more Bis-GMA than TEGDMA (P<0.05). The total monomers eluted was higher in samples cured with halogen curing unit than LED (P=0.001); in addition, saliva caused elution of more monomer than water (P=0.007). CONCLUSION: In conclusion, chemical property of monomers, power of curing light unit and the type of immersion media play key roles in the quantity of eluted monomers from composite resins. Saliva and halogen curing unit can cause greater monomer leaching from hybrid resins composite.

Efficacy of CO(2) laser for treatment of anthroponotic cutaneous leishmaniasis, compared with combination of cryotherapy and intralesional meglumine antimoniate.

BACKGROUND: Cutaneous leishmaniasis (CL) is endemic in developing countries. Several types of treatments have been suggested, but none of them is completely effective and without side-effects. CO(2) laser has a specific thermolysis effect on infected tissues in CL. OBJECTIVES: To determine the efficacy and safety of CO(2) laser vs. combined cryotherapy and intralesional meglumine antimoniate (glucantime) in dry-type CL. METHODS: This is a prospective, randomized open trial study (Kerman, Iran) from November 2007 to August 2009. A total of 96 patients were randomly assigned to receive one session of CO(2) laser therapy and 95 patients on combined cryotherapy biweekly with intralesional meglumine antimoniate weekly until complete cure or up to 12 weeks, whichever is earlier. Clinical and laboratory cure, defined as complete re-epithelialization of 100%, complete flattening of induration and negative smear of lesions compared with baseline at weeks 2, 6, 12 and 16, and also at the time of complete cure (week 2, 6, 12 or 16). RESULTS: Of 191 participants, 80 patients with 95 lesions in group A and 80 patients with 95 lesions in group B completed the study. Complete cure was 93.7% (89/95 lesions) in group A and 78% (74/95 lesions) in group B. Complications were similar in the two groups and were limited to the ulcer sites. CONCLUSIONS: The CO(2) laser was more effective in treating dry-type cutaneous leishmaniasis than combined cryotherapy and intralesional glucantime and resulted in a shorter healing time (6 weeks vs. 12 weeks) with a single treatment session.

Helicobacter pylori and rosacea.

Recent reports have suggested an increased prevalence of Helicobacter pylori infection in patients with rosacea, with some evidence of dermatological improvement in patients treated with antibiotics for this infection. Our study investigates the prevalence of H. pylori infection in rosacea patients in Kerman. Serological examination was done for 29 patients with classical identification of rosacea using the enzyme-linked immunosorbent assay IgG antibody method. Comparison of antibody titres with those of a control group revealed that the prevalence of positive serological tests for H. pylori was significantly higher in the test group. This supports the suggestion of some form of relationship between rosacea and H. pylori infection, though further investigations with larger sample sizes are required for a definite conclusion.