ABSTRACT
The dynamics of string growth was studied in model homochiral solutions of biomimetics, trifluoroacetylated amino alcohols (TFAAA) in heptane, water, and inverted heptane-water emulsion. In heptane and water, a thick (~1 µ in diameter) string had a crown of thin strings on its growing terminal and these thin strings effectively adsorbed dissolved TFAAA. In emulsion, the strings grew inside the water droplets, in which this TFAAA cannot be solved, presumably due to transport of TFAAA molecules from heptane into water in the surface layer surrounding the string. Applications of these phenomena to in vivo cell commutation were discussed.
Subject(s)
Amino Alcohols/chemistry , Biomimetic Materials/chemistry , Heptanes/chemistry , Water/chemistry , Animals , Cell Communication/physiology , Chlorocebus aethiops , Emulsions , Models, Chemical , Surface Properties , Trifluoroacetic Acid/chemistry , Vero CellsABSTRACT
A concept of physicochemical forms of biologically active substances introduced in investigation of the action mechanism of ultra-low doses allows qualitative explanation of the main effects of ultra-low doses, chemical diversity of biologically active substances, and physical boundaries for these effects. Phenazepam was shown to possess activity in ultra-low doses only in disperse state, in the form of nanoparticles with a diameter <100-300 nm; these nanoparticles appear as micelles of surface active substances and solvated. Panavir possesses pharmacological activity in ultra-low doses and appears as nanoparticles with a diameter of 200-300 nm, which have uncompensated negative surface charge and polymer nature.
Subject(s)
Benzodiazepines/chemistry , Benzodiazepines/pharmacology , Nanoparticles/chemistry , Probucol/chemistry , Probucol/pharmacology , Animals , Dose-Response Relationship, Drug , Micelles , Peritonitis/drug therapy , Rats , Surface-Active Agents/chemistryABSTRACT
A phenomenon of superspiralization was revealed in homochiral solutions of biomimetics with strings lengths from 10(2) nm to 10(2) µ and longer: strings of greater size spontaneously formed in solution are twined of the smaller strings, which also have a helical structure. The chiral pitch depends on the conditions of formation of a particular string and can vary by several times in different strings of the same specimen.
